Search results for "esca"

Desarrollo y validación del Cuestionario de Personalidad Vocacio-nal Adaptativa: un cuestionario para analizar la conducta vocacional de estudiantes …

2013

This study presents a personality evaluation instrument adapted to the vocational setting: the Adaptive Vocational Personality Questionnaire (AVPQ). The questionnaire was developed and tested in a sample of 2160 university students in the final years of their degree programs. The purpose of the study is to validate the questionnaire, providing evidence about its internal structure and its usefulness for predicting scores on a criterion scale. A confirmatory factor analysis combined with a cross-validation design was used: the exploratory sample (n = 879) helped to identify the model with the factorial structure that best fit the relations among the items. As expected, this model had two rel…

‘Adso of Montier-en-Der’

1998

Voce enciclopedica, con particolare riguardo alla produzione escatologia di Adso e alla sua circolazione in Inghilterra

A Phase I dose-escalation study of third-line regorafenib with trifluridine/tipiracil in metastatic colorectal cancer

2021

Aim: To determine a recommended Phase II dose of the oral fluoropyrimidine trifluridine/tipiracil (FTD/TPI) combined with the multi-kinase inhibitor regorafenib (REG) in refractory metastatic colorectal cancer patients. Materials & methods: A conventional 3 + 3 dose finding design was used. FTD/TPI was administered on days 1–5 and 8–12 of a 28-day cycle, REG on days 2–22. Two dose levels were used: FTD/TPI 25 mg/m2 b.i.d. + REG 120 mg/d, then escalated to FTD/TPI 35 mg/m2 b.i.d. + REG 120 mg/d. Results: In total, 12 patients were treated at two dose levels. Three dose-limiting toxicities were observed; all were grade 3 hypertension causally attributed to REG. Recommended Phase II dose …

Problematic video game use as an emotional coping strategy: Evidence from a sample of MMORPG gamers

2019

Background A positive relationship between problematic gaming and escapism motivation to play video games has been well established, suggesting that problematic gaming may result from attempts to deal with negative emotions. However, to date, no study has examined how emotion dysregulation affects both escapism motives and problematic gaming patterns. Methods Difficulties in emotion regulation, escapism, and problematic involvement with video games were assessed in a sample of 390 World of Warcraft players. A structural equation modeling framework was used to test the hypothesis that escapism mediates the relationship between emotion dysregulation and problematic gaming. Results Statistica…

A phase I dose-escalation study of the immunocytokine EMD 521873 (Selectikine) in patients with advanced solid tumours.

2012

Abstract Background EMD 521873 (Selectikine), an immunocytokine comprising a DNA-targeting antibody, aimed at tumour necrosis, fused with a genetically modified interleukin-2 (IL-2) moiety, was investigated in this first-in-human phase I study. Methods Patients had metastatic or locally advanced solid tumours failing previous standard therapy. Selectikine was administered as a 1-hour intravenous infusion on 3 consecutive days, every 3weeks. A subgroup of patients also received 300mg/m 2 cyclophosphamide on day 1 of each cycle. Escalating doses of Selectikine were investigated with the primary objective of determining the maximum tolerated dose (MTD). Results Thirty-nine patients were treate…

Impact of HBV genotypes A and D genetic variability on infection evolution

2015

HBV is characterized by a high genetic variability, which is the basis of its classification into eight genotypes (A-H). HBV infection is associated with different outcomes, from self-limiting acute hepatitis to active chronic hepatitis, asymptomatic carriage, and occult infection. The aim of this study was to analyze the genetic variability of HBV genotypes A and D isolates from 79 cases of self-limiting acute hepatitis and chronic hepatitis, in order to identify HBV variants associated with resolution or chronicity of acute HBV infection. The entire preS-S sequence and a fragment of 346 bp of the preC-C region, containing Enhancer II and Basal Core Promoter sequences, were analyzed. A phy…

Neuroprotective effects of behavioural training and nicotine on age-related deficits in spatial learning.

2006

Studies in humans and animals show a clear decline in spatial memory with age and several approaches have been adopted to alleviate this impairment. The purpose of our review is to assess the studies that have suggested the possible neuroprotective actions of behavioural training and nicotine-applied both independently and in conjunction-on age-related deficits in spatial learning. Both spatial pretraining and nonspatial experiences influence an animal's performance in spatial tasks. In aged rats, the experience of training in the water maze task increases the number of newly generated neurons in the hippocampus. The neuroprotective effects of nicotine have been demonstrated in both in-vitr…

Data from: Effects of undergrowth removal and edge proximity on ground beetles and vascular plants in urban boreal forests

2019

Urban forests are regularly managed for human safety and aesthetic reasons, but they are crucial habitat for many species. Removals of undergrowth occur commonly in these forests, yet the ecological consequences of these operations are poorly understood. We sampled ground beetles (Coleoptera, Carabidae) and vascular plants along 20-m edge gradients in Finnish urban forests, in five stands treated 0.5−2.5 years earlier with undergrowth removal and in five untreated stands. We hypothesized that undergrowth removal and edge proximity would benefit opportunistic and open-habitat species, whereas shady-habitat species would be affected negatively. (1) Regarding carabids, diversity and evenness i…

International Legal Approaches to Waste Water Discharges

2002

Este capítulo se dedica al estudio de los distintos enfoques jurídicos seguidos en el Derecho Internacional del Medio Ambiente sobre las descargas de aguas residuales. Comienza analizando los enfoques jurídicos fragmentarios iniciales sobre las descargas de aguas residuales, principalmente en la Antártida y el Océano Austral, en algunos mares regionales (especialmente, el Mediterráneo) y el caso particular de las descargas de basuras procedentes de buques. No obstante, dedico la parte principal de este capítulo al enfoque global que sobre esta cuestión clave de la contaminación marina se inició en 1995, así como a su aplicación jurídica global, regional y nacional. This chapter is devoted t…

Demonstracion historico-chronologica de un engaño, o inconsideracion, que padeciò, y trasladò a la prensa ... Fr. Marcos de Alcala ... sobre, y en as…

Port. amb orla tip. i cites literàries orlades al verso Caplletres ornades, fris, banda Sign.: ¶-¶¶¶4, A-P4, Q2 Postil·les marginals Reclams