Search results for "evaluation"
showing 10 items of 1974 documents
The influence of addition of Borago officinalis with antibacterial activity on the sensory quality of fresh pasta
2015
Abstract Borage (Borago officinalis L.) is a herbaceous plant of the Boraginaceae family cultivated throughout the world for several purposes, including food preparations, mainly beverages and salads. Some Italian recipes use borage as a food ingredient, in particular as condiment for pasta. The aqueous extract (AE) from borage leaves can act as biopreservative in foods due to its inhibition towards the main foodborne pathogen bacteria. Fresh pasta, due to the high content of water, is a food product with a limited shelf life. In order to test the suitability of borage to produce fresh pasta with a prolonged shelf life, borage AE was used in dried form as a raw material for the production o…
Conhecimento pedagógico do conteúdo nas ciências: estado da arte
2017
RESUMEN En este artículo se lleva a cabo una revisión descriptiva de la literatura que permite dar a conocer qué es el Conocimiento Didáctico del Contenido -CDC- en ciencias y qué se ha investigado sobre el mismo. En concreto, se analiza: a) cómo se define, qué características tiene y cómo se ha determinado en los profesores; b) su relación con el conocimiento de la materia a enseñar y con el aprendizaje de los estudiantes; c) cómo se ha utilizado en la formación y evaluación del profesorado; y d) en qué temas científicos se ha estudiado. Se concluye que el CDC se perfila como una herramienta fundamental para mejorar la calidad de la formación del profesorado. ABSTRACT This paper gives a de…
Del abuso de las palabras. La crisis de la crítica cinematográfica en Argentina
2016
Resumen: el presente trabajo analiza la formación del modelo depreciado de la crítica cinematográfica argentina desde 1990 y toma como caso testigo la publicación especializada El amante. Se plantea la edificación de un sistema de validación mutua con el BAFICI (Buenos Aires Festival Internacional de Cine Independiente) y la Universidad del Cine y cómo esto contribuye a la gestación de la marca Nuevo Cine Argentino. Abstract: This article analyses the forming of the devaluation model of Argentine film criticism since 1990, using El amante journal as a case study. The piece presents the construction of a mutual validation system by BAFICI (Buenos Aires International Independent Film Festi…
The cytotoxicity of resin composites cured with three light curing units at different curing distances.
2011
Objective: The purpose of this study was to compare the effect of light curing distance on the cytotoxicity of five resin composites cured with three high-power light curing units. Study design: Seven cylindrical discs of each material (Grandio ®, Voco; Filtek ? Z250, 3M ESPE; Clearfil ? AP-X, Kuraray Co. Ltd.; Aelite ? LS, Bisco Inc. and Simile ®, Pentron) were cured. For curing, soft-up mode of quartz-tungsten-halogen, exponential mode of light emitting diode for 20 s, and ramp-curing mode of plasma arc light curing units for 6 s were used. The curing tip distances were determined as 2 and 9 mm and controlled via the use of metal rings. After ageing the samples for 24 and 72 hours in Dulb…
Substituting a Substitute Currency – The Case of Estonia
2002
This study evaluates substitution of foreign currency balances in Estonia, a transition economy neighbouring countries participating in EMU. The focus is on substitution between dollar and euro balances in the three basic functions of money - unit of account, store of value and means of payment. While traditional models for currency substitution concentrate on substitution between a domestic currency and aggregate foreign currency balances, we look for substitution between the dollar and the euro or euro-related foreign currency balances. We find substitution between dollarization and euroization to be asymmetric in the short run, which suggests that inertia, irreversibility and ratchet eff…
Scaling Consultative Selling with Virtual Reality: Design and Evaluation of Digitally Enhanced Services
2018
Virtual, augmented, and mixed reality technologies allow creation of powerful customer experiences and illustrative demonstrations especially in use cases that benefit from spatial visualizations. Our study focuses on the natural resource management sector and digitalizing of consultative selling process. More specifically, we look at how to improve customer engagement with the use of virtual reality (VR) and thus digitally scale consultative selling. In this process, a VR application is used to demonstrate various management operations and their economic results. Design research methodology is applied to a pre-development phase and three application development iterations between 2016 and …
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
2009
After more than two decades of research into phosphodiesterase 4 (PDE4) inhibitors, roflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-di-chloropyrid-4-yl]-benzamide) may become the first agent in this class to be approved for patient treatment worldwide. Within the PDE family of 11 known isoenzymes, roflumilast is selective for PDE4, showing balanced selectivity for subtypes A-D, and is of high subnanomolar potency. The active principle of roflumilast in man is its dichloropyridyl N-oxide metabolite, which has similar potency as a PDE4 inhibitor as the parent compound. The long half-life and high potency of this metabolite allows for once-daily, oral administration of a single, 500…
Daratumumab for the Treatment of Multiple Myeloma
2018
This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.
Combining dasatinib with dexamethasone long-term leads to maintenance of antiviral and antileukemia specific cytotoxic T cell responses in vitro
2012
Maintaining graft versus leukemia (GvL) and antivirus responses of cytotoxic T cells (CTLs) while suppressing graft-versus-host disease (GvHD) remains a challenge after allogeneic bone marrow transplantation. Clinical observations indicate that combining glucocorticoids with multi-tyrosine-kinase inhibitors could be a successful therapeutic approach. We and others have shown that the BCR-ABL/SRC kinase inhibitor dasatinib may enhance or suppress T cells in vitro. In this report, we evaluated combination effects of dasatinib and dexamethasone on CD3 + and virus-specific CD8 + T cells directly ex vivo and on antigen-specific leukemia-reactive and alloreactive CD8 + T cell clones. Functional o…