Search results for "evidence"
showing 10 items of 1050 documents
Kinetic Analysis: A Sensitive Outcome Objective Measurement Method in Evaluating Lateral Patellar Instability
2011
There are many diagnostic clinical tests (e.g., apprehension patellar test or the moving patellar apprehension test), outcome measures (general health and knee scales [IKDC form, Kujala scale, Fulkerson scale, Lysholm knee scoring scale, Tegner activity level scale, short form-36]), and instrumented measurements of patellar mobility (static stability), to assess lateral patellar instability.7,10,15,16 However, according to Smith and colleagues,15 the sensitivity/specificity – reliability/validity of such tests and outcome tools remain unclear for this patient population. These authors conclude that further work is needed to assess the appropriateness of these tests and outcomes.15Moreover, …
Synergies in Design and Health. The role of architects and urban health planners in tackling key contemporary public health challenges
2020
Background and aim: Important public health improvements have been achieved over the past decades, but new challenges are emerging and progress cannot be taken for granted. Urban settlements host most of the global population, but they are also sources of several threats. The aim of the paper is to investigate the role of architects and planners in contributing to overcome these critical health challenges and propose strategic actions for collaboration with the public health workforce. Methods: Taking global trends and public health challenges as starting point, a scoping literature review has been conducted to illustrate the possible synergies that architecture and public health workforce …
Molluscan antimicrobial peptides, a review from activity-based evidences to computer-assisted sequences
2011
Antimicrobial peptides (AMPs) represent the most universal immune effectors. Molluscs constitute the second largest animal phylum, after Arthropods, in term of number of species. Only a negligible number has been investigated regarding AMPs. The choice of the species to be studied relied on their economical importance and availability. First studies on molluscan AMPs dated from 1996 and were based on biological activities of biochemical-purified fractions. Such approach released all the original structures we know, with biological activity sometimes different from one isoform to another. Then, molecular biology techniques were applied to molluscan AMPs starting in 1999. Complete screening o…
Need for speed? Exploring the relative importance of patents and utility models among German firms
2017
Despite the wide use of two-tiered patent systems (patents and utility models (UMs)), there is little empirical evidence about how often UMs are actually used, what kind of firms use them to protect their intellectual property, and how firms rank them relative to patents. We offer such an analysis using data from Germany. We find that larger firms are more likely to use both protection methods. Moreover, a short life cycle of products and services is associated with an increased likelihood to use UMs. The features and functioning of the German UM system are of broader interest because it has been a benchmark for several second tier patent protection systems around the world. peerReviewed
Public-service provision in clientelist political settlements: Lessons from Ghana's urban water sector
2015
The politics of public-service delivery continues to be neglected under the supposedly more context-sensitive post-Washington Consensus. Using interviews and documentary evidence from Ghana, this article provides an account of the networks of political interference and informal practices in Ghana's public water utility. It argues that, in order to understand why private-sector participation succeeds or fails and why similar arrangements have different outcomes across developing countries, we need to examine the effects of the informal institutional context, particularly the country-specific political settlement in which public-service provision operates.
Prekluzja dowodowa w postępowaniu przed sądem II instancji
2021
Problematyka prekluzji dowodowej w instancji odwoławczej wiąże się z zaprezento-waniem przedmiotowego zagadnienia w kontekście art. 427 § 3 k.p.k. w zw. z art. 452 k.p.k. Łączna interpretacja wskazanych przepisów pozwala wyprowadzić wnioski co do faktycznego zakresu obowiązywania prekluzji dowodowej w postępowaniu przed sądem II instancji i jego wpływu na model postępowania odwoławczego. Dokonując wykładni art. 427 § 3 k.p.k., wskazać należy, że zawiera on w swej treści sformułowania normatywne wymagające do-precyzowania od strony teoretyczno-praktycznej. Znaczenie „nowych” faktów lub dowodów w ujęciu tego przepisu należy dookreślić na podstawie reguł interpretacyjnych wynikają-cych z art. …
Evidence-based sentencing y evidencia científica. A la vez, algunas consideraciones sobre las «políticas basadas en la evidencia» y el Derecho Penal
2020
El evidence-based sentencing (EBS) es una denominación reciente para una pretensión que tiene hondas raíces en el Derecho penal: aplicar las penas más adecuadas al nivel de riesgo de reincidencia que presenta cada condenado para intentar reducir ese riesgo al mínimo posible. Esta versión moderna de la prevención especial se inserta en el enfoque más amplio de las «políticas públicas basadas en la evidencia». Considera que la mejor evidencia existente para el control de la reincidencia son las modernas herramientas de valoración estructurada del riesgo, y aduce ser capaz de lograr varios objetivos a la vez: reducir la reincidencia, mantener un elevado nivel de seguridad ciudadana, hacer un…
The CHRONOS Real-World Evidence of Biologic Treatments in Psoriatic Arthritis in Italy: A Post Hoc Gender Analysis
2022
: Background: Phenotypic features and outcome differences between sexes have been reported in psoriatic arthritis (PsA). However, little is known about sex differences in effectiveness of biologics in clinical practice. Methods: Post hoc gender analysis of the CHRONOS, a multicenter, noninterventional, retroprospective Italian real-world study assessing 6-month and 1-year effectiveness of biologics for PsA. Results: Eligible patients were 399, 43.1% men. Sociodemographic characteristics, type of arthritis, baseline Disease Activity Score 28 joints (DAS28), and duration of biologic treatment were rather homogeneous. More men were overweight/obese and naive to biologics. The most frequently u…
Ensuring the comparability of cross-national survey data on intimate partner violence against women: a cross-sectional, population-based study in the…
2020
Objectives To ensure the cross-national comparability of the set of questions addressing physical and sexual intimate partner violence against women (IPVAW) included in the European Union (EU) Agency for Fundamental Rights (FRA) survey. Once the measurement invariance of these measures is established, we aim to make appropriate and valid comparisons of the levels of physical and sexual IPVAW across the EU countries. Design Cross-sectional, population-based study. Participants Data were drawn from the survey conducted by the FRA on violence against women, including the responses of 42 002 adult women from the 28 countries of the EU. Main outcome measures The set of questions addressing lifet…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…