Search results for "expression"
showing 10 items of 5168 documents
In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides
2012
Withania somnifera (L.) Dunal (Indian ginseng, winter cherry, Solanaceae) is widely used in traditional medicine. Roots are either chewed or used to prepare beverages (aqueous decocts). The major secondary metabolites of Withania somnifera are the withanolides, which are C-28-steroidal lactone triterpenoids. Withania somnifera extracts exert chemopreventive and anticancer activities in vitro and in vivo. The aims of the present in silico study were, firstly, to investigate whether tumor cells develop cross-resistance between standard anticancer drugs and withanolides and, secondly, to elucidate the molecular determinants of sensitivity and resistance of tumor cells towards withanolides. Usi…
Distinguishing the Need to Belong and Sense of Belongingness: The Relation between Need to Belong and Personal Appraisals under Two Different Belongi…
2023
People are frequently caught in the hold between the need to belong and the fear of exclusion. However, these needs might be expressed differently under different belongingness conditions, where other powerful social processes are accentuated. Thus, the need to belong and social exclusion are concepts that are subjectively appraised based on one’s social relations. The present study aims to examine the relationship between the need to belong and five personal appraisals under two different belongingness conditions: (1) social-emotion support and (2) social-value representation. A total of 201 participants from two different groups were presented with 69 different items measuring five person…
Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
2010
Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…
Costrutti locativi e non locativi con mettere
2013
Sentence (a) Ada mise Pio nel sacco is ambiguous: one of its meanings is literal (Ada put Pio in the sack), whereas the other is figurative (Ada fooled / outsmarted Pio). Such ambiguity is not present in sentence (b) Ada mise Pio in un sacco. On the surface, (b) differs from (a) only insofar as the indefinite article is employed, but conveys a literal meaning exclusively (Ada put Pio in a sack). The ambiguity of sentence (a) is derived from the existence of two constructions employing mettere. The prepositional phrase of one of them displays standard paradigmatic properties and conveys literal (i.e. locative) meaning, whereas the other has no locative value and is highly constrained (e.g. n…
Ceļojumu naratīvu lingvistiskā analīze
2021
Ceļojumu literatūra ir informatīva un izklaidējoša, tomēr pētnieki kā Lisle, Tompsons, Azaraija u.c. uzskata to arī par ideoloģiski piesātinātu. Pētījuma mērķis bija noteikt, vai izvēlētajam tekstuālajam materiālam no C. Tompsona ceļojumu memuāra ir ideoloģizēta teksta pazīmes. Empīriskā analīze tika veikta, balstoties uz piecām diskursīvām stratēģijām, kas ir nosaukšanas, apgalvošanas, argumentācijas, perspektivizācijas, pastiprināšanas vai mīkstināšanas stratēģijas, galveno uzmanību pievēršot tādam lingvistiskam materiālam kā lietvārdi, īpašības vārdi un darbības vārdi, kurus visbiežāk izmanto, lai ideoloģizētu stāstītās situācijas un notikumus. Pētījuma dati liecina, ka izmantotās lingvi…
Numerical expressions in everyday language
2016
This interesting volume was published by the Laterza in 2011 and is the product of fruitful collaboration between three internationally renowned scholars, each with different research perspectives. They are respectively Carla Bazzanella, who teaches General and Cognitive Linguistics at the University of Turin; Rosa Pugliese, who teaches Italian as a foreign language at the University of Bologna; Erdling Strudsholm, who teaches Italian linguistics at the University of Copenhagen.
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.
2015
Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…
Current caselaw discrepancies in the protection of national symbols and state representatives between the European Court of Human Rights and Spanish …
2021
Despite the general consensus about freedom of expression being a basic fundamental right on every democratic society, the debate about its boundaries has never found such a pacific agreement. Thus, the Spanish Penal Code has several articles that punish its abuse that are highly contested, like articles 490.3 and 543 that penalize the offenses directed towards national symbols or State representatives. This being so, this article examines the controversy generated by the application of this articles through the analysis of two judgements issued by the European Court of Human Rights against Spain, and a third one issued by the Spanish Constitutional Court that could follow the same path. Th…
Web crawling dla celów lingwistycznych. Wybrane aspekty gromadzenia i analizy danych tekstowych na przykładzie rosyjskojęzycznych newsów internetowych
2021
Autor niniejszego artykułu zgromadził ok. 2,7 mln rosyjskojęzycznych newsów internetowych. Zasadnicze cele tego tekstu stanowią: omówienie pojęcia web crawlingu w odniesieniu do pozyskiwania internetowych danych tekstowych, omówienie kwestii strukturyzacji takich danych w nieanotowanych korpusach tekstowych, a także przedstawienie wybranych aspektów analizy danych strukturyzowanych w ten sposób. Autor rozpatruje newsy internetowe jako połączenie tekstu zasadniczego oraz identyfikujących i charakteryzujących go metadanych (wyróżnionych podczas automatycznej ich ekscerpcji ze stron internetowych). Rozdział newsów na tekst zasadniczy i metadane stwarza możliwość przeprowadzenia ich analizy z d…
WRKY gene family drives dormancy release in onion bulbs
2022
Onion (Allium cepa L.) is an important bulb crop grown worldwide. Dormancy in bulbous plants is an important physiological state mainly regulated by a complex gene network that determines a stop of vegetative growth during unfavorable seasons. Limited knowledge on the molecular mechanisms that regulate dormancy in onion were available until now. Here, a comparison between uninfected and onion yellow dwarf virus (OYDV)-infected onion bulbs highlighted an altered dormancy in the virus-infected plants, causing several symptoms, such as leaf striping, growth reduction, early bulb sprouting and rooting, as well as a lower abscisic acid (ABA) level at the start of dormancy. Furthermore, by compar…