Search results for "expression"

Las formas cotidianas de la felicidad y sus mandatos: Pedagogías del pensamiento positivo, trabajo docente y subjetividad en el neoliberalismo contem…

2020

Positive thinking constitutes one of the great traditions that lead to the idea of the subject as an entrepreneur of himself and is perhaps one of the best that has successfully condensed cultural, political, social and pedagogical processes linked to reflection on well-being in this historical time. The teaching work is especially moved by the pregnancy of these perspectives that challenge the pedagogical field and the education workers as ?agents of change, or at least one more school available to give the discussion on well-being and happiness (yours and the students?) is celebrated and encouraged. In this article, I intend to understand what is being built as pedagogical discourses abou…

Fostering learning opportunities through employee participation amid organizational change

2014

Health care organizations are facing rapid changes, frequently involving modification of existing procedures. The case study reported here examined change processes and learning in a health care organization. The organizational change in question occurred in the emergency clinic of a Finnish central hospital where a new action model for shift-specific nursing supervision was being introduced. The aim of this study was to investigate some of the employee participation and learning opportunities amid this organizational change. The data collection was ethnographically informed, and the data consisted of audio-recorded and observed meetings, observations of the new action model, and field inte…

Pro-apoptotic activity of the phytochemical Indicaxanthin on colorectal carcinoma cells (Caco-2) and epigenetic CpG demethylation of the promoter and…

2012

Phytochemicals play prominent roles in human diet and nutrition as protective redo-active substances in prevention of several disorders and chronic diseases in humans. Today, their function as potent modulators of the mammalian epigenome-regulated gene expression is rapidly emerging. In the present study antiproliferative effects of Indicaxanthin (Ind) from the fruits of Opuntia ficus-indica (1), and potential influence on DNA methylation has been investigated on Caco-2 cells, a human cell line of colorectal carcinoma. Ind caused a clear dose- and time-dependent decrease of the cell proliferation (IC(50) 50 M) associated to apoptosis as demonstrated by phosphatidylserine externalization an…

Protein Phosphorylation by Peroxisome Proliferators: Species-specific Stimulation of Protein Kinases and Its Role in PP-induced Transcriptional Activ…

1996

Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

2009

The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. However, the underlying mechanisms and genetic programmes regulated by AhR to cause adverse effects but also to counteract poisoning are still poorly understood. Here we analysed the effects of two AhR ligands, benzo[a]pyrene (B[a]P), a DNA damaging tumour initiator and promotor and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a pure tumour promoter, on cell survival and on nucleotide excision repair (NER) gene expression. NER deals with so called "bulky" DNA adducts including those generated by enzymatically activated B[a]P. Therefore, t…

Heterogeneity within and between primary colorectal carcinomas and matched metastases as revealed by analysis of Ki-ras and p53 mutations

2004

Analysis of the genetic status of Ki-ras and p53 in primary colorectal carcinomas and matched colorectal liver metastasis from 30 patients reveals an overall heterogeneity both within and between the two tumoral tissues. Both genes were found mutated with a similar frequency in both tissues; however, identical mutations in primary tumor and matched metastasis were found less frequently in the case of the Ki-ras than the p53 gene. Only in three cases the same p53 and Ki-ras mutations found in the primary tumor were found also in the metastasis. In several metastatic specimens the DNA bearing a mutation detected also in the primary tumor appears significantly less abundant than the wild-type …

UV-B exposure causes DNA damage and changes in protein expression in northern pike (Esox lucius) posthatched embryos.

2012

The ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and…

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

pD-l1 expression in oral squamous cell carcinoma microenvironment and prognostic correlations

2018

Backgroun of this study is to investigate the PD-l1 expression in the Microenvironment of oral Squamous cell carcinoma (oScc) samples and its correlation to prognostic data.

Nuorten miesten kirjeitse ohjailemat seurustelusuhteet 1800-luvun lopun sisäsuomalaisella maaseudulla

2014

Artikkelissa tarkastellaan 1800-luvun Keuruun käräjäkunnassa, sisäsuomalaisella maaseudulla eläneiden nuorten miesten ja naisten seurustelusuhteiden kehittymistä kohti avioliittoa ja sitä, kuinka tälle tielle alkoi kasautua ongelmia. Tutkimuksen ensisijaisena lähdeaineistona ovat miesten seurustelusuhteiden aikana kumppaneilleen lähettämät intiimit yksityiskirjeet (12 kappaletta), jotka naiset olivat tuoneet aviottoman lapsen elatusoikeudenkäynteihin todisteeksi suhteen aikaisesta seksuaalisesta kanssakäymisestä. Artikkeli sijoittuu kansanihmisten kirjoittamia tekstejä tarkastelevaan monitieteiseen historiantutkimuksen alaan. Artikkelissa esitetään, että kirjeet kirjoittaneet miehet pyrkivä…