Search results for "extension"

The logic of forms in the light of developmental biology and palaeontology.

2010

11 pages; If you ask palaeontologists, and indeed anyone interested in the theory of evolution, for the key words that encapsulate it, you will obtain the following results: adaptation, natural selection, speciation, but also ontogeny and phylogeny. The first three key words apply to the future of the individual and by extension to the future of the species: we are therefore dealing with adults of a reproductive age. The two other key words concern (i) the evolution of the morphology from the egg to the adult (individual ontogeny: short timescale) and especially what goes on in the black box called embryogenesis, and (ii) the modification of ontogenetic sequences over time, resulting in cha…

Engineered axon tracts within tubular biohybrid scaffolds

2021

[EN] Injuries to the nervous system that involve the disruption of axonal pathways are devastating to the individual and require specific tissue engineering strategies. Here we analyse a cells-biomaterials strategy to overcome the obstacles limiting axon regeneration in vivo, based on the combination of a hyaluronic acid (HA) single-channel tubular conduit filled with poly-L-lactide acid (PLA) fibres in its lumen, with pre-cultured Schwann cells (SCs) as cells supportive of axon extension. The HA conduit and PLA fibres sustain the proliferation of SC, which enhance axon growth acting as a feeder layer and growth factor pumps. The parallel unidirectional ensemble formed by PLA fibres and SC …

Reveglucosidase alfa (BMN 701), a GILT-tagged recombinant human acid alpha glucosidase (rhGAA), evaluation in late-onset Pompe disease: Preliminary c…

2015

An Interactive Multiple Objective Linear Programming Method for a Class of Underlying Nonlinear Utility Functions

1983

This paper develops a method for interactive multiple objective linear programming assuming an unknown pseudo concave utility function satisfying certain general properties. The method is an extension of our earlier method published in this journal (Zionts, S., Wallenius, J. 1976. An interactive programming method for solving the multiple criteria problem. Management Sci. 22 (6) 652–663.). Various technical problems present in predecessor versions have been resolved. In addition to presenting the supporting theory and algorithm, we discuss certain options in implementation and summarize our practical experience with several versions of the method.

Large characteristically simple sections of finite groups

2021

In this paper we prove that if G is a group for which there are k non-Frattini chief factors isomorphic to a characteristically simple group A, then G has a normal section C/R that is the direct product of k minimal normal subgroups of G/R isomorphic to A. This is a significant extension of the notion of crown for isomorphic chief factors.

Combining data from high-energy p p -reactions and neutrinoless double-beta decay: Limits on the mass of the right-handed boson

2016

From the recently established lower-limits on the nonobservability of the neutrinoless double-beta decay of 76Ge (GERDA collaboration) and 136Xe (EXO-200 and KamLAND-Zen collaborations), combined with the ATLAS and CMS data, we extract limits for the left-right (LR) mixing angle, of the SU(2)L ×SU(2)R electroweak Hamiltonian. For the theoretical analysis, which is a model dependent, we have adopted a minimal extension of the Standard Model (SM) of Electroweak Interactions belonging to the SU(2)L ×SU(2)R representation. The nuclear-structure input of the analysis consists of a set of matrix elements and phase-space factors, and the experimental lower-limits for the half-lives. The other inpu…

The importance of extranodal extension in metastatic head and neck squamous cell carcinoma, in the light of the new AJCC cancer staging system

2017

Correction to: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases

2019

No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).A series of 22 ENE-positive CRCs was considered and three samples per case were selected (the primary CRC, an ENE-negative and an ENE-positive metastatic LN). Samples (n = 66) were analysed by immunohistochemistry for PD-L1, CD4, CD8, CD68 and CD80. Fifteen out of twenty-two cases were further profiled through a hotspot multigene mutational custom panel, including 164 hotspot regions ofA significantly higher percentage of CD4-, CD8- and CD68-positive cells was observed at the invasive front of both CRCs and in ENE in contrast with what observed at the …

Author's reply to : Pancreatic cancer : Extension of tumor is associated with timeliness of care and with survival in a population-based study

2018

Prognostic impact of extra-nodal extension in thyroid cancer: A meta-analysis

2015

Background and Objectives Lymph node involvement is common in thyroid cancer, but the system of staging does not consider the histological features of lymph node metastases. We conducted a meta-analysis to investigate the prognostic role of extranodal extension (ENE) in thyroid cancer patients. Methods We ran PubMed and SCOPUS searches without language restrictions. Prospective studies reporting data on overall mortality, cancer-specific mortality, or disease recurrence including thyroid cancer patients, in which cases with ENE (ENE+) were compared with those with only intranodal disease (ENE-) were eligible. Data were summarized using risk ratios (RR) for number of deaths/recurrences, and …