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showing 10 items of 6421 documents
Development and Validation of the Adolescent and Children in Risk of Abuse and Maltreatment Protective Factors Scale (ACRAM-PFS)
2022
AbstractBackgroundChild maltreatment is a significant global problem concerning over 25% of children around the world. Traditionally, the assessment of children’s welfare was characterized by the creation of instruments and models from the deficit-based theoretical framework.PurposeThis study aims to develop an instrument to measure protective factors (the Adolescent and Children Risk of Abuse and Maltreatment Protective Factors Scale, ACRAM-PFS) and gather evidence on its psychometric properties. ACRAM-PFS is an 18-items scale for the assessment of protective factors of child maltreatment developed from the socioecological framework.MethodStructural validity, reliability and convergent-rel…
Ajan henki lain kirjaimessa : suomalaisten lastensuojelulakien ja -asetusten ideologiat
2019
The Spirit of Time in the Letter of the Law. The Ideologies of Finnish Child Welfare Legislation analyses what kinds of ideologies are construed in child welfare legislation and how. It is based on a critical discourse analysis in the fields the work is situated in: language studies and social sciences. The results are applicable in the drafting and interpretation of language for professional use. In the First Child Welfare Act and Decree (1936), ideology is construed as an educational ideology in which the authorities are guided in, and largely required to take particular institutional and educational measures for child welfare when specified conditions are met. Children, young people, par…
New more polar symmetrical choline kinase inhibitors II: Study of setting up a new scaffold for the cancer therapy
2015
MULTIFUNCTIONAL HYALURONIC ACID DERIVATIVE FOR EASY SCAFFOLD PROCESSING AND BIOLOGICAL FUNCTIONALIZATION
2015
The Chorioallantoic Membrane Assay in Nanotoxicological Research—An Alternative for In Vivo Experimentation
2020
Nanomaterials unveil many applicational possibilities for technical and medical purposes, which range from imaging techniques to the use as drug carriers. Prior to any human application, analysis of undesired effects and characterization of their toxicological profile is mandatory. To address this topic, animal models, and rodent models in particular, are most frequently used. However, as the reproducibility and transferability to the human organism of animal experimental data is increasingly questioned and the awareness of animal welfare in society increases at the same time, methodological alternatives are urgently required. The chorioallantoic membrane (CAM) assay is an increasingly popu…
Wykorzystanie dwuwymiarowej chromatografii cieczowej w analizie związków farmaceutycznych w próbkach wód środowiskowych
2015
DYSPHORIC-LIKE BEHAVIOUR DURING ETHANOL WITHDRAWAL IN FEMALE RATS. EFFECT OF CONTINUOUS VS INTERMITTENT ACCESS PARADIGM.
2014
Women show higher vulnerability for neuroadaptation to alcohol, which may contribute to negative emotional state during withdrawal (Sharrett-Field et al., 2013; Koob and Le Moal, 1997). This study aimed at exploring the effects of different patterns of voluntary ethanol consumption on female rat"s affective behaviour during withdrawal. Female rats underwent 12-week-, 2-bottle choice- continuous or intermittent (3 days/week ) access to 20% ethanol and were respectively named CARs and IARs. They were tested for alcohol preference; dysphoric-like state during withdrawal (24-48h); depressive- and anhedonic-like behaviours explored by forced swim- and saccharin preference tests; anxiety-like beh…
4,5,6,9-tetraidropirrolo[2',3':3,4] cicloepta[1,2-d] isossazoli, procedimento per la loro produzione e loro uso come antitumorali
2016
La presente invenzione riguarda derivati a struttura 4,5,6,9- tetraidropirrolo[2',3':3,4]cicloepta[1,2-d]isossazolica, procedimenti per la loro produzione e il loro uso per la cura di patologie a carattere iperproliferativo comprese quelle di natura neoplastica. I nuovi derivati saggiati al National Cancer Institute di Bethesda su un pannello di circa 60 linee cellulari umane divise in 9 sottopannelli (mammella, ovaie, polmone, colon, SNC, melanoma, leucemia, rene, prostata), hanno mostrato attività antiproliferativa da micro a nanomolare, rivelando alcuni derivati particolarmente promettenti
Efecto de las ciclooxigenasas en la biodisponibilidad del óxido nítrico en la respuesta vascular al tromboxano A2 en un modelo murino de envejecimien…
2018
El envejecimiento y la pérdida de los estrógenos durante la menopausia se asocian a una menor biodisponibilidad del NO, un aumento de los niveles de O2- vascular y un incremento de sustancias contráctiles, entre ellas el TXA2. Queda por determinar si los efectos deletéreos vasculares inducidos por el TXA2 durante el envejecimiento median una disminución en la biodisponibilidad de NO y un aumento en la producción de O2- y si están modulados por estrógenos. Para ello, se validó un modelo de envejecimiento vascular en ratonas con senescencia acelerada (SAM), con ratonas de la cepa SAMP8 con predisposición a la senescencia acelerada y ratonas SAMR1, con resistencia al desarrollo de senescencia …
Vaccinium sugu ogu spiedatlieku ekstraktu efekti uz alfa - amilāzes aktivitāti in vitro
2018
Alfa – amilāzes un alfa – glikozidāzes enzīmi ir iesaistīti ogļhidrātu pārstrādes procesā, un to inhibēšana var samazināt glikozes līmeni asinīs, kas īpaši svarīga diabēta slimniekiem, lai novērstu postsprandiālo hiperglikēmiju. Ir atrastas vairāk nekā 1200 augu valsts sugas, kas atzītas par antidiabētiskiem līdzekļiem. Darba mērķis ir izpētīt melleņu, krūmmelleņu, lielogu dzērveņu, purva dzērveņu un brūkleņu alfa – amilāzes aktivitātes inhibīcijas spēju. Salīdzināti tika ogu ekstraktu ūdens un metanola šķīdumu efektivitāte, izmantojot kolorimetrisko metodi. Pētījuma rezultāti apliecina, ka visi ogu ekstrakti inhibē alfa – amilāzi, bet metanolā šķīstošā frakcija izrādījās aktīvāka nekā ūden…