Search results for "far"
showing 10 items of 6421 documents
Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine, a new ring system as potential COX inhibitor
2012
Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.
Pre-conceptional and Peri-Gestational Maternal Binge Alcohol Drinking Produces Inheritance of Mood Disturbances and Alcohol Vulnerability in the Adol…
2018
Although binge drinking is on the rise in women of reproductive age and during pregnancy, the consequences in the offspring, in particular the inheritance of alcohol-related mood disturbances and alcohol abuse vulnerability, are still poorly investigated. In this study, we modeled both Habitual- and Binge Alcohol Drinking (HAD and BAD) in female rats by employing a two-bottle choice paradigm, with 20% alcohol and water. The exposure started 12 weeks before pregnancy and continued during gestation and lactation. The consequences induced by the two alcohol drinking patterns in female rats were assessed before conception in terms of behavioral reactivity, anxiety- and depressive-like behavior.…
Anti-tumor activity of the methanolic extracts of Salvia menthifolia
2012
In the present research we investigated the anti-proliferative activity of Salvia menthifolia Ten. (formerly Salvia menthaefolia), Lamiaceae, on a glioblastoma cell line, since up to date poor therapeutic results have been reported for treatment of malignant glioblastoma. Methanol extracts from different anatomical parts of S. menthifolia were tested on DBTRG-05MG cell line by MTT assay. The most active primary stems extract was also evaluated for apoptosis induction. Results confirmed the anti-tumor property of all the organs and demonstrated that the primary stems extract induced apoptosis after 4 h with the highest values of DNA fragmentation after 6 to 24 h. Some extracts were also HPLC…
The role of two non-indigenous serpulid tube worms in shaping artificial hard substrata communities: case study of a fish farm in the central Mediter…
2019
Understanding the spread and establishment of non-indigenous species (NIS) is one of the primary areas of focus in bioinvasion science and is essential for generating appropriate management strategies in aquaculture. Here we investigated the role of 2 non-indigenous serpulid tube worms (Hydroides elegans and H. dirampha) in shaping the hard substrata communities around a fish farm in the Strait of Sicily over 1 yr (June 2014-June 2015), at 3 mo intervals (September and December 2014, March and June 2015). The mean density values of serpulids were significantly different at each sampling time. The density of serpulids on submerged panels showed a peak in spring (March 2015, after 9 mo) and d…
Predicción de la reincidencia con delincuentes juveniles: un estudio longitudinal
2016
espanolEl presente trabajo tiene como finalidad determinar la utilidad de una escala en la prediccion de la reincidencia de los delincuentes juveniles. Se realizo un estudio longitudinal con una muestra de 258 delincuentes juveniles que se hallaban cumpliendo una medida judicial. El instrumento que evaluo la prediccion de la reincidencia fue el Youth Level of Service/Case Management Inventory, cuyo resultado de su adaptacion al castellano es el Inventario de Gestion en Intervencion para Jovenes (IGI-J). Los jovenes delincuentes reincidentes y no reincidentes puntuaron de la forma esperada en los valores obtenidos en la prueba. No obstante, los resultados indican que el IGI-J identifica a to…
On the Prevalence of Addicted or Problematic Gaming in Finland
2019
Highlights • A dataset from Finland in 2015 (systematic random sampling N = 4511) suggests an (unweighted) prevalence rate of certain “addicted gaming” (videogame play) to be 0.6% among local gamers and 0.03% among the whole population. • The implied prevalence of certain “problematic gaming” (videogame play) climbs to 1.4% among local gamers and 0.6% among the whole population. • Of those “addicted” individuals to whom videogame play was a problem “almost always,” eight reported their hours of play during a week (72, 30, 10, 7, 4, 1, 1, 1), which indicate that “addicted gaming,” if understood as excessive play, might not be optimal for describing such problems.
El modelo criminológico de evaluación e intervención para menores en conflicto con la ley/The criminological model of assessment and intervention for…
2016
Los países occidentales han experimentado en las cuatro últimas décadas una inclinación hacia modelos de justicia más reactivos, punitivos o retribucionistas (Garland, 2005; Giménez y Alba, 2014). Ha sido especialmente dentro del ámbito anglosajón (Estados Unidos y Gran Bretaña) donde esta nueva cultura del delito ha sido más destacable (Ashworth, 2005; Fernández-Molina, 2008). Europa, sin embargo, ha sabido resistirse a esta tendencia punitiva, intentando mantener un precario equilibrio entre los modelos propiamente retribucionistas y las políticas de bienestar. Por su parte, en Latinoamérica, en un intento por suavizar esta corriente punitiva, en la última década se ha evolucionado hacia …
Antimafia e movimenti delle donne. Protagoniste, culture, linguaggi
2016
Il saggio analizza il ruolo giocato dalle donne nei movimenti antimafia a partire dalla loro presenza –cospicua e importante – all’interno dei Fasci dei lavoratori in Sicilia alla fine dell’800 fino alle esperienze del Comitato dei Lenzuoli e dell’Associazione donne per il digiuno nate a Palermo all’indomani delle stragi di Capaci e di via D’Amelio, in cui le figure femminili hanno svolto un ruolo di primo piano sperimentando forme espressive e di mobilitazione civile alternative ed efficaci. L’approccio scelto per l’analisi incrocia gli studi sulla mafia come sistema di potere violento e totalitario con la relazione tra i sessi, intesa come scontro di poteri, in cui svolge un peso determin…
The ECHR Condemns Prison Overcrowding in Italy: The Total Reorganization of the Institution and the Social Reintegration of the Prisoner
2017
The contribution analyses the current Italian prison system, which has been called upon on to resolve its structural problems. The Council of Europe, in fact, in 2013 condemned Italy for inhuman treatment in its prisons. The principal accusation concerns the problem of overcrowding. The country has responded with solutions such as the application of the open system, which provides cells solely for overnight stays, and dynamic monitoring, an effective system for ensuring order in the institutions. These initiatives aim to promote re-educational activities and the social re-integration of prisoners. In addition, Italian institutions have made greater use of alternatives to custodial penalties…
Reconstructing Care Professionalism in Finland
2015
The public sector plays a special role in the Nordic welfare states through its commitment to the principle of universalism, and in relation to social security and publicly funded services in education, health and care (Rostgaard 2002). In the 21st century, the impact of economic austerity on public resources and a rapid aging of the population have forced welfare states to undergo an extreme reform. In Finland, the reform has meant streamlining the state, restraining public expenditure and recalibrating the universalistic ideals behind the Nordic welfare state model, as well as introducing new management models (Pollitt & Bouckaert 2011). The managerial reforms implemented in Finland have …