Search results for "fibrinolysis"
showing 2 items of 82 documents
Intrahematomal Ultrasound Enhances RtPA-Fibrinolysis in a Porcine Model of Intracerebral Hemorrhage
2021
Catheter-based ultrasound-thrombolysis has been successfully used in a small clinical trial in order to enhance recombinant tissue plasminogen activator (rtPA)-fibrinolysis, for the treatment of spontaneous intracerebral hemorrhages (ICHs). The aim of this study was to investigate the ultra-early effects of ultrasound on hematoma and the surrounding brain tissue in a porcine ICH-model. To achieve this, 21 pigs with a right frontal ICH were randomly assigned to four groups: (1) drainage (n = 3), (2) drainage + rtPA (n = 6), (3) drainage + ultrasound (n = 6), and (4) drainage + ultrasound + rtPA (n = 6). The hematoma volume assessment was performed using cranial MRI before and after the treat…
Impact of physical effort on von Willebrand factor’s activity and concentration in blood
2020
Background and Study Aim: Physical exercise causes a wide range of physiological changes including the production and release of haemostasis regulating factors. One of these factors is von Willebrand factor (vWf)- a glycoprotein responsible for both platelet adhesion and coagulation cascade. Material and Methods: The impact of physical effort on von Willebrand’s factor’s concentration (vWf:Ag) and activity (vWf:CBA) underwent analysis in the group of 42 people (22 men and 20 women) aged 19-22 (mean 20, SD 8 months). Physical effort was induced by 35 minutes of swimming in indoor swimming pool. Results: Physical exercise in form of swimming causes an increase of Willebrand’s factor’s concent…