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RESEARCH PRODUCT
Intrahematomal Ultrasound Enhances RtPA-Fibrinolysis in a Porcine Model of Intracerebral Hemorrhage
Karl-friedrich KreitnerAxel HeimannTristan KlodtChristian SchneiderOliver KempskiYasemin TanyildiziNaureen KericFlorian RingelHammoud ElmehdawiAndrea KronfeldClemens SommerJulia Masomi-bornwasserHarald Krenzlinsubject
medicine.medical_treatmentlcsh:Medicine030204 cardiovascular system & hematologyArticle03 medical and health sciences0302 clinical medicineHematomaEdemartPA-fibrinolysisFibrinolysismedicineminimally invasive therapycardiovascular diseasesIntracerebral hemorrhagebusiness.industryUltrasoundlcsh:RGeneral Medicinemedicine.diseaseintracerebral hemorrhageCatheterImmunohistochemistrymedicine.symptombusinessNuclear medicinePerfusion030217 neurology & neurosurgeryultrasound-thrombolysisdescription
Catheter-based ultrasound-thrombolysis has been successfully used in a small clinical trial in order to enhance recombinant tissue plasminogen activator (rtPA)-fibrinolysis, for the treatment of spontaneous intracerebral hemorrhages (ICHs). The aim of this study was to investigate the ultra-early effects of ultrasound on hematoma and the surrounding brain tissue in a porcine ICH-model. To achieve this, 21 pigs with a right frontal ICH were randomly assigned to four groups: (1) drainage (n = 3), (2) drainage + rtPA (n = 6), (3) drainage + ultrasound (n = 6), and (4) drainage + ultrasound + rtPA (n = 6). The hematoma volume assessment was performed using cranial MRI before and after the treatments. Subsequently, the brain sections were analyzed using HE-staining and immunohistochemistry. The combined treatment using rtPA and ultrasound led to a significantly higher hematoma reduction (62 ± 5%) compared to the other groups (Group 1: 2 ± 1%
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-03 | Journal of Clinical Medicine |