Search results for "figuration"
showing 10 items of 615 documents
Individual and environmental factors underlying life space of older people – study protocol and design of a cohort study on life-space mobility in ol…
2012
Abstract Background A crucial issue for the sustainability of societies is how to maintain health and functioning in older people. With increasing age, losses in vision, hearing, balance, mobility and cognitive capacity render older people particularly exposed to environmental barriers. A central building block of human functioning is walking. Walking difficulties may start to develop in midlife and become increasingly prevalent with age. Life-space mobility reflects actual mobility performance by taking into account the balance between older adults internal physiologic capacity and the external challenges they encounter in daily life. The aim of the Life-Space Mobility in Old Age (LISPE) p…
Activity as a predictor of mental well-being among older adults
2006
This eight-year follow-up study examines the roles of physical and leisure activity as predictors of mental well-being among older adults born in 1904-1923. As part of the Evergreen project, 1224 (80%) persons aged 65-84 years were interviewed at baseline (1988), and 663 (90%) persons in the follow-up (1996). Mental well-being factors including depressive symptoms, anxiety, loneliness, self-rated mental vigour and meaning in life were constructed using factor analysis. The predictors of mental well-being included physical and leisure activity, mobility status and number of chronic illnesses. We used a path analysis model to examine the predictors of mental well-being. At baseline, low numbe…
Synthesis, configuration, and calcium modulatory properties of enantiomerically pure 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates.
1992
Enantiomerically pure hexahydroquinolinones of the structural type 9 were prepared by a variation of the Hantzsch synthesis in which an optically active acetoacetate served as a chiral auxiliary reagent. Determinations of the de and ee values are described. The absolute configurations of the optically pure products were characterized by single-crystal X-ray analysis. The antipodes 9a and 9b exhibited calcium antagonistic activities on smooth musculature; the (S)-(-)-enantiomer 9b was the more potent compound with regard to the EC50 values which differed by a factor of 100; the intrinsic activity of 9b was 1.2, compared with a value of 0.54 for 9a. On the other hand, R-(+)-9a exerted positiv…
Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4’-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol…
2007
Abstract Recently we identified ( R , S )-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ( 6 ) as a potent non-competitive AMPA receptor antagonist able to prevent epileptic seizures. We report here the optimized synthesis of compound 6 , its resolution by chiral preparative HPLC, and the absolute configuration of ( R )-enantiomer established by X-ray diffractometry. The biological tests of the single enantiomers revealed that higher anticonvulsant and antagonistic effects reside in ( R )-enantiomer as also suggested by molecular modeling studies.
The WHAAM Application: a Tool to Support the Evidence-Based Practice in the Functional Behaviour Assessment
2018
BackgroundThe most recent computing technologies can promote the application of evidence-based practice (EBP) in the field of applied behaviour analysis (ABA).ObjectiveThe study describes how the use of technology can simplify the application of EBPs in ABA.MethodsThe Web Health Application for ADHD Monitoring (WHAAM) application demonstrates this in the following two case studies. We are monitoring dysfunctional behaviours, collecting behavioural data, performing systematic direct observations, creating both visual baseline and intervention charts and evaluating the planned interventions using the TAU-U statistical index.ResultsSignificant positive changes of children’s problem behaviours …
Hilliness and the Development of Walking Difficulties Among Community-Dwelling Older People
2018
Objective: The objective of this study is to study the associations of objectively defined hilliness with the prevalence and incidence of walking difficulties among community-dwelling older adults, and to explore whether behavioral, health, or socioeconomic factors would fully or partially explain these associations. Method: Baseline interviews ( n = 848, 75-90 years) on difficulties in walking 500 m, frequency of moving through the neighborhood, and perceived hilliness as a barrier to outdoor mobility were conducted. Two-year follow-up interviews ( n = 551) on difficulties in walking 500 m were conducted among participants without baseline walking difficulties. Hilliness objectively defin…
Exploring the viability of equity crowdfunding as a fundraising instrument: A configurational analysis of contingency factors that lead to crowdfundi…
2020
Abstract With the growth in the use of crowdfunding platforms for fundraising, analysis of the key factors associated with successful crowdfunding has emerged as an interesting and oft-researched topic. Nonetheless, the equity crowdfunding market is still relatively under researched. The purpose of this paper is to explore how contingency factors combine and causally connect in leading to possible success or failure in equity crowdfunding rounds. To reach this goal, a configurational approach was chosen. Qualitative comparative analysis (QCA) is a suitable method for this topic because of its ability to identify and assess different combinations of conditions that explain certain outcomes. …
Firm survival: The role of incubators and business characteristics
2015
This paper analyzes the impact of business incubators on firm survival. Using a configurational comparative method, namely fuzzy-set qualitative comparative analysis (fsQCA), the article also examines whether degree of business innovation, size, sector, and export activity affects firm survival. Results show that, when combined with other variables (i.e. sector, technology), business size is a sufficient condition for firm survival. Likewise, incubators alone cannot affect survival. A combination between incubators and other factors is necessary to ensure firm survival. Sin financiación 2.129 JCR (2015) Q2, 40/120 Business UEV
Activity of the Elderly in an Eight-Week Case Study
2015
This study explores the engagement of the elderly with a new health-enhancing mobile-optimised web-service: An eight-week case study was carried out. Participants of the study were elderly people: 45 females and 19 males with the average age of 72.3 (SD 5.2) years. Their baseline information and communication technology experiences were evaluated, the data of using each service component was saved to a server and the usability of the service was evaluated. The majority of the users remained active throughout the study. The most frequently used components in the study were memory puzzles and physical exercise. The usability of the components was correlated with the age of the participants. T…
Exhibitors’ Performance at International Trade Shows: Does Export Firms’ Experience Matter?
2021
A myriad of combinations of organizational characteristics is more likely to be successful than a limited number. To test this, we conducted an analysis comparing a variables’ single effect with th...