Search results for "filamentation"
showing 10 items of 28 documents
Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model
2021
ABSTRACT Candida auris is an emergent multidrug-resistant fungal pathogen considered a severe global threat due to its capacity to cause nosocomial outbreaks and deep-seated infections with high transmissibility and mortality. However, evidence on its pathogenicity and the complex host-pathogen interactions is still limited. This study used the in vivo invertebrate model in Galleria mellonella to assess its virulence, exploring the mortality kinetics, melanization response, and morphological changes after fungal infection compared to Candida albicans and Candida parapsilosis, with known high and low pathogenicity, respectively. All C. auris isolates presented less virulence than C. albicans…
The 5' Untranslated Region of the
2018
Many of the virulence traits that make Candida albicans an important human fungal pathogen are regulated on a transcriptional level. Here, we report an important regulatory contribution of translation, which is exerted by the extensive 5′ untranslated regulatory sequence (5′ UTR) of the transcript for the protein Efg1, which determines growth, metabolism, and filamentation in the fungus. The presence of the 5′ UTR is required for efficient translation of Efg1, to promote filamentation. Because transcripts for many relevant regulators contain extensive 5′ UTR sequences, it appears that the virulence of C. albicans depends on the combination of transcriptional and translational regulatory mec…
Observation d'effets Kerr d'ordres élevés (HOKE) dans les gaz
2011
Talk given by O. Faucher; National audience
Transverse nonlinear optics in heavy-metal-oxide glass
2008
6 pags. ; 9 figs.
Higher-order Kerr effects improve quantitative modelling of harmonics generation and laser filamentation
2013
The consideration of the higher-order Kerr effect (HOKE) drastically improves the quantitative agreement between measured and simulated harmonic yield as well as intensity and electron density in laser filaments generated by pulses below a few hundreds of fs. In longer pulses, the plasma defocusing plays a much more important role.
Higher-order Kerr effect in ultrashort laser pulse propagation and laser filamentation
2011
We discuss the contribution of the higher-order Kerr effect (HOKE) to the propagation of ultrashort laser pulses in several contexts. We show that their consideration is necessary to adequately reproduce experimental data about harmonics generation, propagation in hollow-core fibers, and laser filamentation. In the latter case, our results show that the HOKE play a key role for short pluses and/or long wavelengths, while the plasma contributes more for long pulses and/or short wavelengths.
Transition from plasma-driven to Kerr-driven laser filamentation.
2011
While filaments are generally interpreted as a dynamic balance between Kerr focusing and plasma defocusing, the role of the higher-order Kerr effect (HOKE) is actively debated as a potentially dominant defocusing contribution to filament stabilization. In a pump-probe experiment supported by numerical simulations, we demonstrate the transition between two distinct filamentation regimes at 800 nm. For long pulses (1.2 ps), the plasma substantially contributes to filamentation, while this contribution vanishes for short pulses (70 fs). These results confirm the occurrence, in adequate conditions, of filamentation driven by the HOKE rather than by plasma.
Harmonic Generation and Nonlinear Propagation: When Secondary Radiations Have Primary Consequences
2014
In this Letter, it is experimentally and theoretically shown that weak odd harmonics generated during the propagation of an infrared ultrashort ultraintense pulse unexpectedly modify the nonlinear properties of the medium and lead to a strong modification of the propagation dynamics. This result is in contrast with all current state-of-the-art propagation model predictions, in which secondary radiations, such as third harmonic, are expected to have a negligible action upon the fundamental pulse propagation. By analyzing full three-dimensional ab initio quantum calculations describing the microscopic atomic optical response, we have identified a fundamental mechanism resulting from interfere…
Four-wave mixing control in the filamentation of ultrafast Bessel beams via longitudinal intensity-shaping
2017
International audience; Bessel beams exploit conical energy flow to yield near-uniform intensity along a line focus which has been shown to be extremely attractive for laser processing in dielectrics. At high power, however, the nonlinear Kerr effect is known to induce significant oscillations of the on-axis intensity which is deleterious for machining applications. Here, we show through theory and numerical modelling how this problem can be understood and overcome by appropriate spatial phase shaping of the input profile. Our results also solve the longstanding problem related to the nonlinear Bessel beam dynamics seen at an air-dielectric interface.
Temperature and density structure of hot and cool loops derived from the analysis of TRACE data
2002
We address the plasma structuring both across and along the magnetic field in two sets of solar coronal loops, observed with TRACE in the 17lÅ and 195Å passbands. We derive, after proper background removal, the density stratification and the thermal structure of the plasma in the fibrils forming the loops with two techniques: a) filter ratio diagnostic (195 Å/171 Å) and b) modeling intensity profiles along the fibrils with hydrostatic models. We find evidence of a hot fibril (T ∼ 5·106 K), with temperature and density stratification well-described with a typical non-isothermal hydrostatic loop model, and evidence of rather cold fibrils (T ∼ 2 · 105 K), isothermal and probably in dynamic con…