Search results for "fisiologia"

Identification and functional binding analysis of GPR23/! LPA4 as a candidate G protein-coupled receptor for Guanosine.

2013

Several studies have shown that guanine-based purines exert biological effects on the central nervous system (CNS), possibly through membrane receptors, but at the present there are not reports related to the identification of such specific receptor(s). We have identified the first guanosine G protein-coupled receptor GPR23, also known as LPA4 receptor, involved in the modulation of guanosine-mediated antiproliferative effects in human glioma cell line (U87). We report that the silencing of GPR23 reduces significantly the antiproliferative effects of guanosine, while stably transfected cell clones over-expressing GPR23 increase sensitivity to guanosine. [3H] Guanosine radioligand binding as…

PRESSIONI INTRACRANICHE

2008

Intensive physical training reduces the airway response to methacholine in healthy subjects

2008

La broncoreattività nell'esercizio fisico

2014

Seasonal variation in total phenolic content of Dictyopteris polypodioides (Dictyotaceae) and Cystoseira amentacea (Sargassaceae) from the Sicilian c…

2014

This study focuses on the differences in total phenolic content and its seasonal variations in two temperate brown algae, Cystoseira amentacea (C. Agardh) Bory and Dictyopteris polypodioides (A.P. De Candolle) J.V. Lamouroux, inhabiting respectively the infralittoral fringe and the upper infralittoral zone. Phenolic compounds are secondary metabolites, found in almost all brown algal orders, that function as defense against grazers, epiphytes and UV radiation. Total phenolic content was determined colorimetrically with the Folin-Ciocalteu reagent. Results showed significant differences in total phenol content between D. polypodioides and C. amentacea with higher values observed in the first…

Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon

2007

Abstract It is well accepted that endogenous cannabinoids and CB1 receptors are involved in the regulation of smooth muscle contractility and intestinal motility, through a mechanism mainly related to reduction of acetylcholine release from cholinergic nerve endings. Because, few data exist on a possible modulatory action of the cannabinoid agents on the non-adrenergic non-cholinergic (NANC) excitatory and inhibitory neurotransmission, the aim of the present study was to investigate the effects of cannabinoid drugs on the NANC responses elicited by electrical field stimulation (EFS) in the circular muscle of mouse proximal colon. Colonic contractions were monitored as changes in endoluminal…

Elimination of Citrus variegation virus (CVV) by seed cryotherapy

2014

Citrus variegation ilarvirus (CVV) is one of the oldest viruses reported in Citrus, which produces crinkling, puckering and variegation of leaves in field trees and, occasionally, variegated and deformed fruits. This virus is primarily transmitted by grafting. However, no consistent data are available concerning CVV seed transmission, which is apparently low. The elimination of CVV in citrus genotypes is carried out by shoot-tip-grafting. In the case of seed sources, virus elimination directly in the seeds becomes essential. In cryotherapy, plant pathogens such as viruses, phytoplasmas and bacteria are eradicated by exposing explants to liquid nitrogen. It allows treatment of a high number …

The Role of Vitamin K in Bone Remodeling and Osteoporosis

2012

Vitamin K is an essential fat soluble vitamin involved in the regulation of normal coagulation. However, growing evidence highlights that this molecule appears to be also implicated in the regulation of other important biological functions such as bone mineralization, calcium homeostasis, apoptosis, cell growth and signal transduction. In particular, many studies have focused their attention on the protective effects of vitamin K on bone tissue in the outlook of its use in the prevention and treatment of osteoporosis in post-menopausal women. The objective of the present paper is to review data of the literature regarding the metabolic effects of Vitamin K in bone tissue and its clinical ro…

WIN 55,212-2, agonist of cannabinoid receptors, prevents amyloid β1-42 effects on astrocytes in primary culture

2015

Alzheimer's disease (AD), a neurodegenerative illness involving synaptic dysfunction with extracellular accumulation of Aβ1-42 toxic peptide, glial activation, inflammatory response and oxidative stress, can lead to neuronal death. Endogenous cannabinoid system is implicated in physiological and physiopathological events in central nervous system (CNS), and changes in this system are related to many human diseases, including AD. However, studies on the effects of cannabinoids on astrocytes functions are scarce. In primary cultured astrocytes we studied cellular viability using MTT assay. Inflammatory and oxidative stress mediators were determined by ELISA and Western-blot techniques both in…

Le basi neurologiche del concetto di sacro e influenze sulle sue manifestazioni.

2008

Dopo aver riassunto la ricostruzione dell'origine delle idee religiose, aggiungendo alcune considerazioni, accenneremo alle principali linee di ricerca sui neuromodulatori che si ritengono maggiormente implicati nella genesi delle idee e dei comportamenti religiosi ed, infine, riassumeremo i risultati di nostri studi precedenti sui complessi rapporti fra fattori ambientali (in particolare nutritivi), neurobiologici e culturali che hanno caratterizzato le civiltà dell'America precolombiana, in particolare quella azteca.