Search results for "flex"

SHEAR COMPLIANCE AND SELF WEIGHT EFFECTS ON TRACTION BELT MECHANICS

2007

The transverse elastic deflection of a traction belt along the free span depends mainly on the flexural stiffness, but may be significantly influenced by the distributed weight and the shear compliance, which affect together the width of the arc of contact. In particular, the shear compliance yields a virtual decrease of the flexural stiffness, flattens the free span and increases the wound regions, to the advantage of the transmissible torque. Moreover, the tensioning of a given belt may be somewhat larger, in comparison with the ideal circular-straight path with the same centre distance, because of the increased length of the deflected belt trajectory due to gravity. The present paper ad…

Direct laser welding of pure titanium to austenitic stainless steel

2018

Abstract Direct butt joining of pure titanium to 316L stainless steel with continuous Yb:YAG laser was performed with variation of the beam offset from joint line. Mechanical properties of samples were evaluated by tensile tests and three-point flexural tests. The fractured surfaces and cross sections of welds were examined by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). Tensile properties of welds were strongly determined by the beam offset from joint line and are well described by Weibull statistics. Ultimate tensile strength of 174 ± 69 MPa and ultimate flexural strength of 297 ± 48 MPa were obtained. Brittle fracture took place in…

Integrated WAAM-Subtractive Versus Pure Subtractive Manufacturing Approaches: An Energy Efficiency Comparison

2019

Over the last years, additive manufacturing (AM) has been gathering momentum both in the academic and in the industrial world. Besides the obvious benefits in terms of flexibility and process capabilities, the environmental performance of such processes has still to be properly analyzed. Actually, the advantages of additive manufacturing over conventional processes are not obvious. Indeed, different manufacturing approaches result in different amounts of involved material and in different processing energy demands. Environmental comparative analyses are hence crucial to properly characterize AM processes. In this paper, an energetic comparison between the emerging wire arc additive manufact…

Afinidades entre la arquitectura y la música. Algunas reflexiones

2019

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen

2018

Understanding ecological and epidemiological factors driving pathogen evolution in contemporary time scales is a major challenge in modern health management. Pathogens that replicate outside the hosts are subject to selection imposed by ambient environmental conditions. Increased nutrient levels could increase pathogen virulence by pre-adapting for efficient use of resources upon contact to a nutrient rich host or by favouring transmission of fast-growing virulent strains. We measured changes in virulence and competition in Flavobacterium columnare, a bacterial pathogen of freshwater fish, under high and low nutrient levels. To test competition between strains in genotype mixtures, we devel…

A New Niche for Anoxygenic Phototrophs as Endoliths

2018

ABSTRACT Anoxygenic phototrophic bacteria (APBs) occur in a wide range of aquatic habitats, from hot springs to freshwater lakes and intertidal microbial mats. Here, we report the discovery of a novel niche for APBs: endoliths within marine littoral carbonates. In a study of 40 locations around Isla de Mona, Puerto Rico, and Menorca, Spain, 16S rRNA high-throughput sequencing of endolithic community DNA revealed the presence of abundant phylotypes potentially belonging to well-known APB clades. An ad hoc phylogenetic classification of these sequences enabled us to refine the assignments more stringently. Even then, all locations contained such putative APBs, often reaching a significant pro…

Strategies for structuring interdisciplinary education in Systems Biology: an European perspective

2016

Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins, molecules, cells and organisms. The approach aims at elucidating how these interactions govern biological function by employing experimental data, mathematical models and computational simulations. As Systems Biology is inherently multidisciplinary, education within this field meets numerous hurdles including departmental barriers, availability of all required expertise locally, appropriate teaching material and example curricula. As university education at the Bachelor’s level is traditionally built upon…

Common Hits Approach: Combining Pharmacophore Modeling and Molecular Dynamics Simulations.

2017

We present a new approach that incorporates flexibility based on extensive MD simulations of protein-ligand complexes into structure-based pharmacophore modeling and virtual screening. The approach uses the multiple coordinate sets saved during the MD simulations and generates for each frame a pharmacophore model. Pharmacophore models with the same pharmacophore features are pooled. In this way the high number of pharmacophore models that results from the MD simulation is reduced to only a few hundred representative pharmacophore models. Virtual screening runs are performed with every representative pharmacophore model; the screening results are combined and rescored to generate a single hi…

Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat.

2016

The brain circuits underlying behavioral fear have been extensively studied over the last decades. Although the vast majority of experimental studies assess fear as a transient state of apprehension in response to a discrete threat, such phasic states of fear can shift to a sustained anxious apprehension, particularly in face of diffuse cues with unpredictable environmental contingencies. Unpredictability, in turn, is considered an important variable contributing to anxiety disorders. The networks of the extended amygdala have been suggested keys to the control of phasic and sustained states of fear, although the underlying synaptic pathways and mechanisms remain poorly understood. Here, we…

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathw…

2017

Contains fulltext : 177350.pdf (Publisher’s version ) (Closed access) The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P=3.3 x 10-8; rs191260602, P=3.9 x 10-8). We followed up on this finding in a larger dimensional AC…