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showing 10 items of 7082 documents

Multiple renal aspergillus abscesses in an AIDS patient: contrast-enhanced helical CT and MRI findings.

1999

Renal insufficiency or allergic reactions for X-ray contrast agents are frequent limitations in immunocompromised hosts such as neutropenic or AIDS patients. Due to a better tolerance of contrast agents in MRI, this technique is well suited for investigation of parenchymal organs. We demonstrate an allergic AIDS patient who presented with fever and flank pain. At sonography, anechoic renal lesions were supposed to be non-complicated cysts; however, on T2-weighted MRI, the center was of high signal. Dynamic contrast-enhanced MRI of the kidneys demonstrated an enhancing rim with ill-defined margins. The lesions were supposed to be multiple bilateral abscesses. Due to the multiple dynamic cont…

AdultGadolinium DTPAmedicine.medical_specialtyPathologyBiopsyIohexolContrast MediaAspergillosisAspergillus fumigatusLesionDiagnosis DifferentialFatal OutcomeParenchymaBiopsymedicineAspergillosisHumansRadiology Nuclear Medicine and imagingNeuroradiologyKidneybiologymedicine.diagnostic_testAIDS-Related Opportunistic InfectionsPyelonephritisbusiness.industryAspergillus fumigatusInterventional radiologyGeneral Medicinebiology.organism_classificationmedicine.diseaseMagnetic Resonance ImagingAbscessmedicine.anatomical_structureFemaleRadiologymedicine.symptombusinessTomography X-Ray ComputedFollow-Up StudiesEuropean radiology
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Prevalence of Atrophic Gastritis in Kazakhstan and the Accuracy of Pepsinogen Tests to Detect Gastric Mucosal Atrophy

2019

Background Atrophic gastritis is considered precursor condition for gastric cancer. There is so far limited evidence on the performance of pepsinogens for atrophy detection in Central Asia. The aim of our study was to detect the prevalence of atrophic gastritis in the asymptomatic adult population in Kazakhstan as well as address the accuracy of pepsinogen testing in atrophy detection. Methods Healthy individuals aged 40-64 were included. Upper endoscopy and pepsinogens (PG) evaluation were performed. PG were analysed in plasma by latex agglutination. Cut off values were used to define decreased PG values (PGR ≤ 3 and PG I ≤ 70 ng/mL); severely decreased PG values (PGR ≤ 2 and PG I ≤ 30 ng/…

AdultGastritis AtrophicMale0301 basic medicinemedicine.medical_specialtyAtrophic gastritisPopulationgastricAsymptomaticGastroenterology03 medical and health sciences0302 clinical medicineAtrophyatrophyPepsinPepsinogen AInternal medicinePrevalenceHumansMedicineeducationeducation.field_of_studyPepsinogensbiologyatrophicbusiness.industrygastric cancerscreeninggastritisEndoscopyGeneral MedicineGold standard (test)Middle AgedPrognosismedicine.diseaseKazakhstanLatex fixation test030104 developmental biologyROC CurveGastric Mucosa030220 oncology & carcinogenesisbiology.proteinFemaleGastritismedicine.symptombusinessResearch ArticleFollow-Up StudiesAsian Pacific Journal of Cancer Prevention
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Genome-wide Association Study of Alcohol Dependence

2009

Context Alcohol dependence is a serious and common public health problem. It is well established that genetic factors play a major role in the development of this disorder. Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder. Objective To identify susceptibility genes for alcohol dependence through a genome-wide association study (GWAS) and a follow-up study in a population of German male inpatients with an early age at onset. Design The GWAS tested 524 396 single-nucleotide polymorphisms (SNPs). All SNPs with P −4 were subjected to the follow-up study. In addition, nominally significant SNPs from genes t…

AdultGenetic MarkersMaleGenotypeGenetic LinkagePopulationContext (language use)Single-nucleotide polymorphismGenome-wide association studyBiologyPolymorphism Single NucleotideGenetic determinismArticleAlcohol Withdrawal DeliriumYoung AdultArts and Humanities (miscellaneous)Genetic linkageAnimalsHumansAlleleAge of OnseteducationAllelesGeneticseducation.field_of_studyGene Expression ProfilingAlcohol dependenceAlcohol DehydrogenasePutamenRats Inbred StrainsAmygdalaCadherinsRatsHospitalizationPsychiatry and Mental healthAlcoholismPhenotypeGene Expression RegulationCase-Control StudiesChromosomes Human Pair 2Caudate NucleusLod ScoreFollow-Up StudiesGenome-Wide Association Study
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Effects of immunosuppressive drugs on the cognitive functioning of renal transplant recipients: A pilot study

2011

Some renal transplant patients show cognitive, emotional, and behavioral changes as part of possible neurotoxic effects associated with immunosuppressive medication, especially tacrolimus. This study evaluated effects of immunosuppressive drugs on some cognitive tasks. Patients treated with sirolimus and cyclosporine reported some of the noncognitive side effects related to immunosuppressive treatment. We observed attention and working memory impairment in patients treated with sirolimus or tacrolimus. Performance of cyclosporine-treated subjects was similar to that of healthy volunteer controls. Since the mood, anxiety, and sleep patterns measured were unaffected, it could be concluded tha…

AdultGraft RejectionMaleSleep Wake Disordersmedicine.medical_specialtyPilot ProjectsNeuropsychological TestsDevelopmental psychologyYoung AdultSurveys and QuestionnairesInternal medicinemedicineHumansNeuropsychological assessmentCognitive deficitPsychiatric Status Rating ScalesAnalysis of Variancemedicine.diagnostic_testCognitionMiddle AgedKidney TransplantationTacrolimusTransplantationClinical Psychologysurgical procedures operativeMoodNeurologySirolimusQuality of LifeKidney Failure ChronicAnxietyFemaleNeurology (clinical)medicine.symptomCognition DisordersPsychologyImmunosuppressive AgentsFollow-Up Studiesmedicine.drugJournal of Clinical and Experimental Neuropsychology
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Evolution of Corneal Graft Survival Over a 30-Year Period and Comparison of Surgical Techniques: A Cohort Study.

2015

Purpose To compare graft survival between 3 10-year periods and according to surgical techniques performed in the last years. Design Cohort study. Methods setting: Regional center (Besancon University Hospital, France). patients: All 1132 patients operated on between 1983 and 2014. Graft and patient baseline characteristics, risk factors for failure, surgical procedures, and postoperative corneal status were collected. main outcome measures: Five-year survival rate in the whole cohort; 1-year and 3-year survival rates, respectively, among 88 patients with endothelial dystrophy (ED) or postoperative bullous keratopathy (PBK) operated on using endothelial lamellar keratoplasty (ELK) or penetr…

AdultGraft RejectionMalemedicine.medical_specialtyKeratoconusTime FactorsCorneal graftVisual AcuityCorneal DiseasesCohort StudiesCorneal Transplantation03 medical and health sciences0302 clinical medicineRisk FactorsMedicineHumansProspective StudiesSurvival rateAgedbusiness.industryHazard ratioGraft SurvivalSurgical proceduresMiddle Agedmedicine.diseaseSurgeryOphthalmologyTreatment OutcomeCohort030221 ophthalmology & optometryBullous keratopathyFemaleFrancebusiness030217 neurology & neurosurgeryCohort studyFollow-Up StudiesAmerican journal of ophthalmology
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Freestyle pedicled perforator flaps: safety, prevention of complications, and management based on 85 consecutive cases.

2011

Background: Despite the widespread use of free perforator flaps, pedicled perforator flaps seem not to be as widely accepted, probably because of the fear of vascular complications caused by transfer of a flap attached only by its vascular pedicle, prone to shearing, kinking, and trauma. In this article, the authors report on their experience with 85 consecutive cases, focusing on incidence, prevention, and management of complications. Methods: Eighty-five consecutive cases were treated over 6 years at the Plastic and Reconstructive Surgery Department of the University of Palermo for defects of different causes that were reconstructed with a freestyle pedicled perforator flap, in every regi…

AdultGraft RejectionMalemedicine.medical_specialtyMicrosurgerymedicine.medical_treatmentTreatment outcomeSettore MED/19 - Chirurgia PlasticaRisk AssessmentSurgical FlapsCohort StudiesPostoperative ComplicationsmedicineHumansSurgical Wound InfectionAgedRetrospective StudiesAged 80 and overWound HealingGraft rejectionVascular pediclebusiness.industryGraft SurvivalFollow up studiesFREE STYLESkin TransplantationMicrosurgeryMiddle AgedPlastic Surgery Procedureseye diseasesSurgeryTreatment OutcomeRegional Blood FlowSurgeryGraft survivalFemalebusinessPerforator flapsFollow-Up Studies
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Prognostic Significance of Creeping Proteinuria in the First Year After Transplantation.

2015

BACKGROUND Proteinuria changes have a prognostic significance in proteinuric nephropathies. Proteinuria has been related to kidney transplant outcomes, but there are no information about the impact of increasing proteinuria during the first year on long-term graft and patient survival. METHODS Retrospective cohort study of 591 kidney transplants to analyze the effect on long-term prognosis of: proteinuria at 3 (n = 591) and 12 (n = 583) months (no proteinuria: 150-299 mg/24 hours, 300-999 mg/24 hours, and ≥1 g/24 hours), and changes in proteinuria during the first year in such patients with proteinuria at 3 months (reduction ≥50% of proteinuria from 3 to 12 months, variation <50%, and incre…

AdultGraft RejectionMalemedicine.medical_specialtyTime FactorsPopulationUrologyurologic and male genital diseasesKidney Function TestsmedicineHumanseducationRetrospective StudiesTransplantationeducation.field_of_studyKidneyProteinuriaurogenital systembusiness.industryIncidenceHazard ratioGraft SurvivalRetrospective cohort studyMiddle Agedmedicine.diseasePrognosisKidney Transplantationfemale genital diseases and pregnancy complicationsConfidence intervalSurgeryTransplantationSurvival RateProteinuriamedicine.anatomical_structureSpainFemalemedicine.symptombusinessKidney diseaseFollow-Up StudiesTransplantation
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Tacrolimus Monotherapy Without Steroids After Liver Transplantation – A Prospective Randomized Double-Blinded Placebo-Controlled Trial

2007

Early steroid withdrawal after liver transplantation (LT) is desirable in order to reduce steroid side effects. Between February 2000 and August 2004, 110 patients after LT were included in this prospective, randomized, double-blind, placebo-controlled trial. Randomization was performed before LT. In all patients, tacrolimus was used without induction therapy. All patients received methylprednisolon for 14 days, thereafter a double-blinded medication containing either placebo (n = 56) or methylprednisolon (n = 54) for 6 months, which was completely stopped thereafter. End points were patient and graft survival, acute and chronic rejection, and incidence of steroid side effects during the fi…

AdultGraft RejectionMalemedicine.medical_specialtyTime FactorsRandomizationmedicine.drug_classmedicine.medical_treatmentPlacebo-controlled studyLiver transplantationPlaceboMethylprednisoloneGastroenterologyTacrolimuslaw.inventionPlacebosDouble-Blind MethodRandomized controlled trialAdrenal Cortex HormoneslawInternal medicinemedicineHumansImmunology and AllergyPharmacology (medical)Antibacterial agentTransplantationbusiness.industryMiddle AgedTacrolimusLiver TransplantationSurgeryCorticosteroidFemaleSafetybusinessImmunosuppressive AgentsFollow-Up StudiesAmerican Journal of Transplantation
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Mantenimiento de la lactancia materna exclusiva a los 3 meses posparto: experiencia en un departamento de salud de la Comunidad Valenciana

2019

Resumen: Objetivos: Determinar la prevalencia de la lactancia materna exclusiva (LME) a los 3 meses posparto, y conocer las causas que contribuyen al abandono precoz. Diseño: Estudio observacional y restrospectivo. Emplazamiento: Departamento de Salud de la Ribera, Valencia, España. Participantes: Niños nacidos entre diciembre de 2012 y enero de 2017. Mediciones principales: prevalencia de lactancia materna al alta y de LME a los 3 meses. Motivos de abandono de LME. Determinación de Chi-cuadrado entre variables categóricas. Metodología: Las mujeres fueron entrevistadas en el posparto y a los 3 meses posparto, teniendo en cuenta las variables asociadas al inicio de la lactancia y su continua…

AdultHealth Knowledge Attitudes PracticeBreastfeeding03 medical and health sciences0302 clinical medicineInfants nadonsEarly weaningHumans030212 general & internal medicineProspective Studieslcsh:R5-920030504 nursingLactancia maternaPostpartum PeriodGeneral MedicineDestete precozOriginalesBreast FeedingRisk factorsSpainFemale0305 other medical scienceFamily Practicelcsh:Medicine (General)Factores de riesgoFollow-Up StudiesAtencion Primaria
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The Fontan-Operation: From Intra- to Extracardiac Procedure

2003

Purpose For treatment of univentricular heart, the Fontan operation has been established as the definitive palliation. The current controversy is mainly based on the high incidence of arrhythmias after an intra-atrial lateral tunnel Fontan operation. Methods From January 1995 until April 2002. 46 children underwent a Fontan-type operation with or without a small fenestration. In 33 patients (group I) an Intracardiac tunnel and in 13 patients (group II) an extracardiac conduit procedure was performed. Principal findings There was no perioperative mortality. All patients showed postoperative a significant increase of arterial oxygen saturation, from 76 to 86% after surgery with fenestration, …

AdultHeart Defects CongenitalMalecongenital hereditary and neonatal diseases and abnormalitiesmedicine.medical_specialtyAdolescentmedicine.medical_treatmentGroup iiExtracardiac conduitFontan ProcedureIntracardiac injectionFontan procedureIntraoperative PeriodmedicineHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesChildCardiopulmonary Bypassbusiness.industryInfantPerioperativeSurgical InjuryUniventricular heartSurgeryOxygensurgical procedures operativeChild Preschoolcardiovascular systemFemaleSurgeryHigh incidencebusinessCardiology and Cardiovascular MedicineFollow-Up StudiesCardiovascular Surgery
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