Search results for "force"
showing 10 items of 3423 documents
Chelate Cooperativity and Spacer Length Effects on the Assembly Thermodynamics and Kinetics of Divalent Pseudorotaxanes
2011
Homo- and heterodivalent crown-ammonium pseudorotaxanes with different spacers connecting the two axle ammonium binding sites have been synthesized and characterized by NMR spectroscopy and ESI mass spectrometry. The homodivalent pseudorotaxanes are investigated with respect to the thermodynamics of divalent binding and to chelate cooperativity. The shortest spacer exhibits a chelate cooperativity much stronger than that of the longer spacers. On the basis of crystal structure, this can be explained by a noninnocent spacer, which contributes to the binding strength in addition to the two binding sites. Already very subtle changes in the spacer length, i.e., the introduction of an additional…
Experimental and theoretical NMR studies of interaction between phenylalanine derivative and egg yolk lecithin
2014
The interaction of phenylalanine diamide (Ac-Phe-NHMe) with egg yolk lecithin (EYL) in chloroform was studied by 1H and 13C NMR. Six complexes EYL–Ac-Phe-NHMe, stabilized by N–H···O or/and C–H···O hydrogen bonds, were optimized at M06-2X/6-31G(d,p) level. The assignment of EYL and Ac-Phe-NHMe NMR signals was supported using GIAO (gauge including atomic orbital) NMR calculations at VSXC and B3LYP level of theory combined with STO-3Gmag basis set. Results of our study indicate that the interaction of peptides with lecithin occurs mainly in the polar ‘head’ of the lecithin. Additionally, the most probable lecithin site of H-bond interaction with Ac-Phe-NHMe is the negatively charged oxygen in …
Formation of irreversibly bound annexin A1 protein domains on POPC/POPS solid supported membranes
2008
AbstractThe specific interaction of annexin A1 with phospholipid bilayers is scrutinized by means of scanning force and fluorescence microscopy, quartz crystal microbalance, ellipsometry, and modeled by dynamic Monte Carlo simulations. It was found that POPC/POPS bilayers exhibit phase separation in POPC- and POPS-enriched domains as a function of Ca2+ concentration. Annexin A1 interacts with POPC/POPS bilayers by forming irreversibly bound protein domains with monolayer thickness on POPS-enriched nanodomains, while the attachment of proteins to the POPC-enriched regions is fully reversible. A thorough kinetic analysis of the process reveals that both, the binding constant of annexin A1 at …
Ultimate Shear of RC Beams with Corroded Stirrups and Strengthened with FRP
2019
Transverse reinforcement plays a key role in the response behavior of reinforced concrete beams. Therefore, corrosion of steel stirrups may change the failure mode of elements from bending to shear, leading to a brittle and catastrophic crisis. It is important to strengthen reinforced concrete beams with corroded stirrups to enhance the shear resistance. This paper presents a formulation, based on the modified compression field theory, to estimate the ultimate shear of reinforced concrete beams strengthened with FRP, because of stirrup corrosion. The detrimental effect of corrosion on steel stirrup yield strength was taken into account by introducing an empirical decay law. The effective st…
Nonlinear Analysis of Beams Reinforced in Shear with Stirrups and Steel Fibers
2012
The modified compression field theory (MCFT) and the disturbed stress field model (DSFM) are often used to predict the nonlinear behavior of reinforced concrete structures. This study presents several extensions of the MCFT and DSFM to the case of high-strength steel fiber-reinforced concrete beams subjected to transverse loads. Experimental four-point bending tests were conducted on 12 concrete beams with a different percentage of fibers and/or stirrups. To validate the updates introduced in the analytical models, numerical analysis was performed using nonlinear finite element software. Modeling of the post-peak softening branch of the tensile and compressive constitutive curves of fibrous…
Experimental Tests and FEM Model for SFRC Beams under Flexural and Shear Loads
2008
The complete load-vs-displacement curves obtained by four-point-bending tests on Steel Fiber Reinforced Concrete (SFRC) beams are predicted by using a nonlinear finite element code based on the Modified Compression Field Theory (MCFT) and the Disturbed Stress Field Model (DSFM) suitably adapted for SFRC elements. The effect of fibers on the shear-flexure response is taken into account, mainly incorporating tensile stress-strain analytical relationship for SFRC. The numerical results show the effectiveness of the model for prediction of the behavior of the tested specimens reinforced with light amount of stirrups or with fibers only. © 2008 American Institute of Physics.
Effect of moisture on elastic and viscoelastic properties of fiber reinforced plastics: Retrospective and current trends
2019
Abstract This chapter is a brief review of journal papers and books about moisture and composites with polymer matrix (mostly fiber reinforced composites but not exclusively). Most polymer materials and composites absorb moisture. It is well known from many papers (some of them mentioned in this chapter) over several decades that absorbed moisture essentially affects mechanical and many other important properties of polymers and polymer-based composites. The key question is: How does absorbed moisture affect mechanical properties of composites? Furthermore, the process of moisture absorption in composite structures may occur over many months and even years. More questions then arise: What i…
Spinocerebellar ataxia: functional analysis of the stomatognathic system
2019
Background Neurodegenerative diseases that affect the cerebellum, especially in elderly individuals, cause impairment of motor coordination and quality of life. The presente study evaluated the electromyographic activity and thickness of the right and left masseter and temporal muscles, and the maximum molar bite force of individuals with spinocerebellar ataxia. Material and Methods Twenty-eight individuals were divided into two groups: those with (n=14) and without (n=14) spinocerebellar ataxia. Data on the masticatory muscles obtained from the electromyographic activity (resting, right and left laterality and protrusion), muscle thickness (maximal voluntary contraction and tensile strengt…
Effect of low-calcium diet and grind diet on bone turnover of ovariectomized female rats
2011
Made available in DSpace on 2013-08-12T19:12:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01 Made available in DSpace on 2013-09-30T18:34:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:37Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T14:04:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: The variety of methodologies used to investigate ovariectomized female rats shows different results, which makes a clinical application of these results difficult. The purpose of t…
Fracture Resistance of New Metal-Free Materials Used for CAD-CAM Fabrication of Partial Posterior Restorations
2020
Background and Objectives: To evaluate in vitro the fracture resistance and fracture type of computer-aided design and computer-aided manufacturing (CAD-CAM) materials. Materials and Methods: Discs were fabricated (10 ×