Search results for "friend"

Analysis of basic drugs by liquid chromatography with environmentally friendly mobile phases in pharmaceutical formulations

2017

Abstract Basic drugs are positively charged in the usual working pH (2–8) in reversed-phase liquid chromatography. This gives rise to a strong association with the residual ionized silanols in conventional silica-based stationary phases, which is translated in poor peak shape and high consumption of organic solvent to get appropriate retention times. Micellar mobile phases containing surfactants give rise to modified stationary phases, where silanols are masked, improving the peak shape. However, mobile phases containing the anionic surfactant sodium dodecyl sulfate (SDS) require a small amount of organic solvent to conveniently decrease the retention of cationic analytes. An alternative is…

La giustizia valore supremo presso i Greci?

2020

Nella Grecia antica, la giustizia (il limitarsi passivamente a non fare il male e a rispettare i diritti altrui) è certamente un valore necessario ma spesso non è riconosciuto come valore sufficiente per la vita nella polis. Per tutta una linea di pensiero alla giustizia bisogna aggiungere, come integrazione indispensabile, la virtù attiva del curarsi degli altri. Altrimenti, si avrà un’aggregazione associativa, una somma di individui che si limitano a trattenersi dal compiere ingiustizia ma non si avrà comunità umana, che è solidarietà, ovvero aidós e philía, rispetto e amicizia In ancient Greece, justice (limiting oneself passively to respect the rights of others) is certainly a necessary…

Mechanochemical synthesis of antifungal bis(benzoxaboroles)

2020

Several piperazine bis(benzoxaboroles) have been obtained both in solution as well as in the solid state. The environmentally friendly mechanochemical approach – hitherto not applied for the preparation of benzoxaboroles – was particularly beneficial in the case of two products afforded in low yields in solution. The in vitro studies showed high potential of the studied bis(fluorobenzoxaboroles) as antifungal agents, highlighting also the influence of the fluorine substituent position on their microbiological activity. The highest activity against A. niger, A. terreus, P. ochrochloron, C. tenuis and C. albicans was displayed by the analogue of the known benzoxaborole antifungal drug Kerydin…

Antiproliferative and chemomodulatory effects of interferon-γ on doxorubicin-sensitive and -resistant tumor cell lines

1993

Biological agents might offer various therapeutic opportunities in the treatment of cancer, including a direct and/or host-mediated antiproliferative effect and also the possibility to favorably modulate tumor resistance to antineoplastic drugs. We studied the in vitro antiproliferative effects of interferon (IFN)-gamma on the mouse B16 melanoma and Friend erythroleukemia, and the human K562 erythroleukemia, as doxorubicin (DXR)-sensitive and -resistant (multidrug resistant) variants. These effects were marked in B16 melanoma and rather slight in K562 erythroleukemia, without any difference between the DXR-sensitive and -resistant lines. The chemosensitive variant of Friend erythroleukemia …

Ti(iv)-amino triphenolate complexes as effective catalysts for sulfoxidation

2010

C 3 -symmetric Ti (IV) amino triphenolate complexes efficiently catalyze, without previous activation and in excellent yields, the oxidation of sulfides at room temperature, using both CHP and the more environment friendly aqueous hydrogen peroxide as terminal oxidants, with catalyst loadings down to 0.01%. The Ti(IV) catalysts and the intermediate Ti(IV)-peroxo complexes have been characterized in solution by 1H NMR and ESI-MS techniques and via density functional studies.

Aristotle’s Concept of Friendship and Plato’s Structure of Human Soul

2018

Development of Eco-Friendly and Self-Cleaning Lime-Pozzolan Plasters for Bio-Construction and Cultural Heritage

2020

Summarization: Nowadays, the design and use of multi-functional mortars has increased significantly, with interesting applications in the green building and cultural heritage conservation sectors. A key point for a correct adoption of these innovative materials is their behavior along time and their resistance to the weathering. The objective of this project was to define the performance and durability of innovative mortars, in order to use them correctly and to avoid irreparable damage over time. For the development of this project, lime–metakaolin and hydraulic lime–metakaolin based mortars (hereinafter called A, B), as well as A and B with the addition of nano-TiO2 and perlite (hereinaft…

What can gender tell us about the pre-retirement experiences of elite distance runners in Finland?: A thematic narrative analysis

2016

Abstract Objectives This study explores gendered experiences of the mastery stage in endurance runners' athletic careers in terms of (a) key themes in this period of life, (b) retirement decision-making and (c) changes in athletic and runner identities. Design and method Ten male and nine female athletes aged between 25 and 62 participated in individual interviews. The data were analyzed via thematic narrative analysis. Results and conclusion Gendered meanings permeate career decision-making and retirement patterns of Finnish runners. Female athletes reported many difficulties, including health problems, loneliness, societal pressure and lack of social support during the final years of thei…

Delivering Inorganic and Organic Reagents and Enzymes from Zein and Developing Optical Sensors.

2018

Nowadays, interest in using environmentally friendly materials is increasing in many fields. However, the rational design of sensors with biodegradable materials is a challenge. The main aim of this work is to show the possibility of using zein, a protein from corn, as a biodegradable and low-cost material for immobilizing, stabilizing, and delivering different kind of reagents for developing optical sensors. Enzymes, metallic salts, and aromatic and small organic compounds were tested. In addition, different techniques of immobilization, entrapment and adsorption, were used, and different formats, such as solid devices and also multiwell platforms, were proposed. The capacity of zein for i…

Fundamental frequency of the female's voice: A cross-country empirical study on its influence on social and sexual selection

2020

Recent studies demonstrate that voice (in particular, its fundamental frequency -Fo-) may influence on social and sexual selection. Here, we tested how the Fo of female's voice is related to different aspects of social and sexual selection through a novel experimental approach. First, we recorded and measured the Fo of 22 women reading a neutral text in Spanish language. Six of these voices were selected and classified into three categories: voices with a low Fo (225 Hz). Then, these voices were rated by two independent samples including both men and women: one comprised of native Spanish-speakers (n = 683) and the other comprised of native Italian non-Spanish-speakers (n = 484). Contrarily…