Search results for "functioning"
showing 10 items of 312 documents
Effects of Exercise on Patellar Cartilage in Women with Mild Knee Osteoarthritis
2015
AB Purpose: This study aims to investigate the effects of exercise on patellar cartilage using T2 relaxation time mapping of magnetic resonance imaging in postmenopausal women with mild patellofemoral joint osteoarthritis (OA). Methods: Eighty postmenopausal women (mean age, 58 (SD, 4.2) yr) with mild knee OA were randomized to either a supervised progressive impact exercise program three times a week for 12 months (n = 40) or a nonintervention control group (n = 40). Biochemical properties of cartilage were estimated using T2 relaxation time mapping, a parameter sensitive to collagen integrity, collagen orientation, and tissue hydration. Leg muscle strength and power, aerobic capacity, and…
Axonal control of the adult neural stem cell niche.
2014
SummaryThe ventricular-subventricular zone (V-SVZ) is an extensive germinal niche containing neural stem cells (NSCs) in the walls of the lateral ventricles of the adult brain. How the adult brain’s neural activity influences the behavior of adult NSCs remains largely unknown. We show that serotonergic (5HT) axons originating from a small group of neurons in the raphe form an extensive plexus on most of the ventricular walls. Electron microscopy revealed intimate contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a transsynaptic viral tracer injected into the raphe. B1 cells express the 5HT receptors 2C and 5A. Electrophysiology showed that acti…
Metabolic Status and Reaction to Heat of Normal and Tumor Tissue
1995
The occurrence of differential heating and differential thermal sensitivity between malignant tumors and normal tissues is thought to be due to limited heat dissipation and energy depletion in many solid tumors which in turn results from an inadequately functioning tumor microcirculation (Jain and Ward-Hartley 1984; Song 1984, 1991; Vaupel and Kallinowski 1987; Reinhold 1988; Vaupel et al. 1988a; Vaupel 1990). As a consequence of the latter pathophysiological condition, supply and drainage function are restricted in many solid tumors or, at least, in some tumor areas, thus creating a hostile metabolic microenvironment characterized by tissue hypoxia, acidosis, and energy depletion. Thermal …
The complex cognitive system of executive functioning: A conceptual review
2018
Every day we are faced with a variety of situations that require the use of cognitive processes different, such as recognizing and memorizing stimuli, understanding and producing statements, solving problems. In recent decades, cognitive psychology and neuropsychology have made considerable advances in description of these processes and how they can be disrupted as a result of an injury to the nervous system central. However, it is clear that our adaptation to the environment is not limited to perceiving, reading, and speaking. A fundamental aspect of mental life is represented by the need to continuously modulate the use of these cognitive resources to contingent needs according to our goa…
Social interactional behaviors and symbolic play competence as predictors of language development and their associations with maternal attention-dire…
1999
Abstract Children’s early social interactional behaviors and symbolic play competence were studied at 14 months in a sample of 111 mother-infant pairs. The categories of social interactional behaviors, joint visual attention, socially coordinated and object oriented interactions were assessed via observations of mother-infant joint play. An index of symbolic play was derived from the child’s solitary play, which was assessed independently. We examined both the interrelations of these two types of early language predictors, and their relation to children’s language skills and maternal attention-directing strategies. Measures of children’s language comprehension and production were obtained u…
Utility of the Mantel-Haenszel Procedure for Detecting Differential Item Functioning in Small Samples
2004
Sample-size restrictions limit the contingency table approaches based on asymptotic distributions, such as the Mantel-Haenszel (MH) procedure, for detecting differential item functioning (DIF) in many practical applications. Within this framework, the present study investigated the power and Type I error performance of empirical and inferential criteria for DIF detection in small samples. Sample sizes (50/50, 100/50, 200/50, and 100/100 for the reference and focal groups, respectively), ability distributions (equal and unequal), and amount of DIF (moderate and high) were manipulated. The results show the advantages of employing theMHchi-square statistic using high levels of significance (•…
Exploring the Heterogeneity and Trajectories of Positive Functioning Variables, Emotional Distress, and Post-traumatic Growth During Strict Confineme…
2022
Abstract COVID-19 pandemic-related confinement may be a fruitful opportunity to use individual resources to deal with it or experience psychological functioning changes. This study aimed to analyze the evolution of different psychological variables during the first coronavirus wave to identify the different psychological response clusters, as well as to keep a follow-up on the changes among these clusters. The sample included 459 Spanish residents (77.8% female, Mage = 35.21 years, SDage = 13.00). Participants completed several online self-reported questionnaires to assess positive functioning variables (MLQ, Steger et al. in J Loss Trauma 13(6):511–527, 2006. 10.1080/15325020802173660; GQ…
The impact of strict and forced confinement due to the COVID-19 pandemic on positive functioning variables, emotional distress, and posttraumatic gro…
2021
ABSTRACT Background: The adverse consequences of the COVID-19 pandemic on mental health have been widely studied in recent months. However, few studies have examined the protective psychological factors that may explain how individuals are coping with the COVID-19 pandemic and its forced confinements. Objective: This study analyzes the impact of confinement due to the COVID-19 pandemic on positive functioning variables (resilience, meaning of life, gratitude, compassion, life satisfaction), emotional distress (depression, anxiety, perceived stress, affect), and posttraumatic growth (PTG). The impact was measured during and after the first month of strict and obligatory confinement in Spain.…
Parental Distress and Perception of Children’s Executive Functioning after the First COVID‐19 Lockdown in Italy
2021
The spread of the novel coronavirus (COVID-19), and the consequential first italian lockdown to minimize viral transmission, have resulted in many significant changes in the every-day lives of families, with an increased risk of parental burnout. This study explores the impact of the first COVID-19 lockdown in Italy on parental distress and parental perceptions of children’s executive functions (EFs). Participants were 308 Italian parents with children between 4 and 17 years of age; they were recruited through online advertisements on websites and social media, and they were given an online survey. The measures were: the balance between risks and resources (BR2) and the executive functionin…
Health-related quality of life in elderly cancer patients, elderly non-cancer patients and an elderly general population
2009
Health-related quality of life (QoL) is a major topic within the care for cancer patients (CP). Compared with the general population (GP), QoL of CP is worse in most dimensions; however, only few data comparing QoL of CP with that of other patients have been provided so far. We determined QoL with the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire in hospitalized patients aged 60 years and older: 195 CP and 130 patients treated for other medical disorders (MP). In addition, data were compared with an age- and gender-stratified German GP. Explorative statistical analyses were performed. The CP aged >or=70 years compared with those aged 60-69 years had decrea…