Search results for "furosemide"

Excitotoxic Hippocampal Membrane Breakdown and its Inhibition by Bilobalide: Role of Chloride Fluxes

2003

We have previously shown that hypoxia and N-methyl-D-aspartate (NMDA) receptor activation induce breakdown of choline-containing phospholipids in rat hippocampus, a process which is mediated by calcium influx and phospholipase A (2) activation. Bilobalide, a constituent of Ginkgo biloba, inhibited this process in a potent manner (Weichel et al., Naunyn-Schmiedeberg's Arch. Pharmacol. 360, 609-615, 1999). In this study, we used fluorescence microscopy and radioactive flux measurements to show that bilobalide does not interfere with NMDA-induced calcium influx. Instead, bilobalide seems to inhibit NMDA-induced fluxes of chloride ions through ligand-operated chloride channels. In our experimen…

Changes in Natriuretic Peptides, Cytokines, Selectins and Adhesion Molecules Plasma Levels in Patients with Heart Failure, After Treatment with High …

2007

Analytical Techniques for Furosemide Determination

2006

Abstract Due to the clinical importance of furosemide, a large number of analytical procedures to detect the presence of this drug in pharmaceutical and physiological samples has been developed. In this manuscript, a review of the most frequent analytical techniques described to determine furosemide is presented. Special attention has been paid to spectrophotometric and chromatographic techniques, but also to relevant methods using capillary electrophoresis or flow‐injection analysis, as well as the detection modes coupled to these techniques. The review also focuses on the different degradation pathways of the drug and cautions to prevent it, otherwise rarely or confusedly mentioned in the…

Furosemide assay in pharmaceuticals by Micellar liquid chromatography: study of the stability of the drug.

2000

A simplified high-performance liquid chromatographic procedure is described for the determination of furosemide (4-chloro-N-furfuryl-5-sulphamoylanthranillic acid), which makes use of UV detection, a C18, reversed-phase column, and micellar mobile phases of sodium dodecyl sulphate (SDS) and 1-propanol at pH 3 buffered with phosphate system. The most adequate experimental conditions to handle furosemide solutions in the analytical laboratory are studied. The mixture of furosemide and its degradation products which are formed upon light exposition was resolved with a mobile phase of 0.04 M SDS-2% propanol. Separation of furosemide from its common impurities and the hydrolytic product, 4-chlor…

Determination of furosemide in urine samples by direct injection in a micellar liquid chromatographic system.

2002

A sensitive, selective and efficient micellar liquid chromatographic (MLC) procedure was developed for the determination of furosemide (4-chloro-N-furfuryl-5-sulfamoylanthranilic acid) in urine samples by direct injection and UV detection. The procedure makes use of a C18 reversed-phase column and a micellar mobile phase of 0.05 mol l(-1) sodium dodecyl sulfate-6% v/v propanol and phosphate buffer at pH 3 to resolve furosemide from its photochemical degradation products. The importance of protecting the standards and urine samples to be analysed from light in the assay of furosemide, avoiding its degradation, was verified. The limit of quantification was 0.15 microg ml(-1) and the relative …

The Effect of Dexamethasone and Diuretics on Peritumor Brain Edema: Comparative Study of Tissue Water Content and CT

1976

Eighteen brain tumor patients were pre-operatively treated with dexamethasone, 4 × 4 mg i.m. for 4–6 days, and furosemide, 3 × 40 mg p.o. for 2–4 days. Water and electrolyte content were determined in biopsies removed from peritumoral cortex and white matter during operation and compared with the results from 31 patients not pre-treated and 28 patients treated with dexamethasone alone (16–24 mg i.m./day for 4–6 days). While the water content in cortex did not change significantly it fell in white matter from 79.90 ± 0.81 in untreated to 77.29 ± 0.76 in dexamethasone-treated and to 75.53 ± 1.03 in patients treated with a combination of dexamethasone and furosemide. With the diminution of wat…

High-Dose Torasemide is Equivalent to High-Dose Furosemide with Hypertonic Saline in the Treatment of Refractory Congestive Heart Failure.

2007

Objective: A randomised, double-blind study was performed to evaluate the effects of the combination of high-dose torasemide and hypertonic saline solution (HSS) infusion versus high-dose furosemide (frusemide) and HSS in the treatment of refractory New York Heart Association class IV congestive heart failure (CHF). Materials and methods: Eighty-four patients (55 males, 29 females) with refractory CHF, aged 55–84 years, with an ejection fraction <35%, serum creatinine <2 mg/dL, blood urea nitrogen ≤60 mg/dL, a reduced urinary volume and a low natriuresis, were randomised to two groups. Group 1 (27 males, 15 females) received an intravenous infusion of furosemide 500mg plus HSS (150mL of 1.4…

Polymeric microcontainers improve oral bioavailability of furosemide.

2016

Microcontainers with an inner diameter of 223 μm are fabricated using the polymer SU-8, and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug delivery system for the poorly water soluble drug furosemide. An amorphous sodium salt of furosemide (ASSF) is filled into the microcontainers followed by applying a lid using Eudragit L100. It is possible to control the drug release in vitro, and in vitro absorption studies show that the microcontainers are not a hindrance for absorption of ASSF. In situ perfusion studies in rats are performed with ASSF-filled microcontainers coated with Eudragit and compared to a furosemide solution. The absorption rate constant …

Évaluation de la prescription du furosémide chez la personne âgée de 75 ans et plus dans un service de gériatrie aiguë

2018

Resume Introduction Le furosemide est tres prescrit en France. Il serait responsable d’effets indesirables non negligeables surtout chez la personne âgee. Afin de limiter son mesusage et un surcout pour la securite sociale, la Societe europeenne de cardiologie a edite des recommandations de prescription strictes. Nous avons conduit une etude dans une population âgee dont l’objectif principal etait de determiner le taux de prescription du furosemide chez la personne âgee hors recommandations. Methode Il s’agissait d’une etude prospective, monocentrique et observationnelle portant sur des personnes d’âge ≥ 75 ans, admises dans un service de geriatrie aigue sur une periode de 6 mois. La preval…

Reduced inotropic support after aprotinin therapy during pediatric cardiac operations

1999

Several reports indicate that aprotinin treatment before and during cardiopulmonary bypass (CPB) might have a protective effect on the myocardium. We evaluated the hemodynamic effects of perioperative aprotinin treatment.We conducted a randomized, double-blind, placebo-controlled trial in 34 infants (mean age, 2.5 years) who had cardiac operations. Half of the patients received high-dose aprotinin therapy. There were no significant differences between the aprotinin and placebo groups with respect to age, weight, sex, aortic cross-clamp time, and CPB time. The following data were recorded at arrival in the intensive care unit 6, 12, 24, and 48 hours after termination of CPB: heart rate, bloo…