Search results for "fusion"

Fernand de Montessus de Ballore, à la naissance de la sismologie moderne

2012

Fernand de Montessus de Ballore (1851-1923) est considéré comme un des précurseurs de la sismologie moderne. On lui doit une importante production scientifique dans ce domaine : il a notamment établi, par des relevés rigoureux et nombreux, que les tremblements de terre étaient en relation avec la géologie et non avec les phases de la lune ou les volcans souterrains comme on le supposait au début du XXe siècle. Officier de l'armée française, alors en garnison à Nîmes, il écrit en 1886 au scientifique genevois Louis Soret (1827-1890), qui fait partie de la commission suisse chargée d'étudier les séismes dans ce pays. C'est l'analyse de cette lettre à Soret qui fait l'objet de notre article.

Non-isothermal mass transfer of ferrocolloids through porous membrane

2011

Abstract The present paper deals with transport properties of ferrofluid nanoparticles in non-isothermal capillary-porous layer. Experiment establishes that the temperature difference, which is applied across the layer, induces a thermoosmotic pressure gradient directed toward increasing temperature. The measurement results are interpreted in a frame of phenomenology of linear irreversible thermodynamics. The transport coefficients are evaluated comparing the measured separation curves with approximate solution of the corresponding mass transfer problem.

The Co‐mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion‐Driven Cholangiocarcinoma

2021

Background and aims Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and a highly lethal malignancy. Chemotherapeutic options are limited, but a considerable subset of patients harbors genetic lesions for which targeted agents exist. Fibroblast growth factor receptor 2 (FGFR2) fusions belong to the most frequent and therapeutically relevant alterations in ICC, and the first FGFR inhibitor was recently approved for the treatment of patients with progressed, fusion-positive ICC. Response rates of up to 35% indicate that FGFR-targeted therapies are beneficial in many but not all patients. Thus far, no established biomarkers exist that predict resistance or r…

Non-immune hydrops fetalis: Two case reports

2021

BACKGROUND Fetal hydrops is a serious condition difficult to manage, often with a poor prognosis, and it is characterized by the collection of fluid in the extravascular compartments. Before 1968, the most frequent cause was the maternal-fetal Rh incompatibility. Today, 90% of the cases are non-immune hydrops fetalis. Multiple fetal anatomic and functional disorders can cause non-immune hydrops fetalis and the pathogenesis is incompletely understood. Etiology varies from viral infections to heart disease, chromosomal abnormalities, hematological and autoimmune causes. CASE SUMMARY A 38-year-old pregnant woman has neck lymphoadenomegaly, fever, cough, tonsillar plaques at 14 wk of amenorrhea…

Effects of confinement on insulin amyloid fibrils formation.

2006

Insulin, a 51-residue protein universally used in diabetes treatment, is known to produce amyloid fibrils at high temperature and acidic conditions. As for other amyloidogenic proteins, the mechanisms leading to nucleation and growth of insulin fibrils are still poorly understood. We here report a study of the fibrillation process for insulin confined in a suitable polymeric hydrogel, with the aim of ascertain the effects of a reduced protein mobility on the various phases of the process. The results indicate that, with respect to standard aqueous solutions, the fibrillation process is considerably slowed down at moderately high concentrations and entirely suppressed at low concentration. M…

Synchrony Analysis of Unipolar Cardiac Mapping during Ventricular Fibrillation

2014

Ventricular Fibrillation (VF) is one of the main causes of death in developed countries. Recent studies have shown that fibrillation have a complex organization scheme. This work uses three measures of synchrony to characterize three groups of rabbit hearts. These groups consist of rabbits trained with physical exercise (N=7), untrained rabbits treated with a drug (N=13) and a control group of untrained rabbits (N=15). Cardiac mapping records were acquired using a 240-electrode array placed on left ventricle of isolated rabbit hearts, and VF was induced pacing at increasing rates. Two acquisitions were performed: maintained perfusion, and ischemic damage produced by an artery ligation. The …

Hong Kong’s EDI bandwagon Derailed or on the right track?

1997

In this paper we explore the adoption of a complex networked technology — that of Electronic Data Interchange (EDI) — in the context of Hong Kong. EDI forms a complex and interorganizational innovation and therefore we suggest a multi-theoretical framework to examine its diffusion. The framework takes into account institutional, industry specific and organizational factors in the study of diffusion processes and thus extends the analysis beyond organizational borders. Using the framework we deliver an account of the EDI diffusion in Hong Kong based on field study data. The study clarifies how simultaneous organizational, industry and environmental factors can be brought to bear to understan…

L'accès aux emplois en entreprise des docteurs scientifiques : les impacts des collaborations industrielles

2000

This thesis studies the entrance to firms of the science Ph.D graduates, notably as industrial researcher. Particularly, the impacts of collaborations between the academic sphere and the industry are examined. In this perspective, the first part is dedicated to the elaboration of a frame of analysis. This one establish links between the process of production of the knowledge, the training and the access to the labour market. The analysis of the preparation of the doctorate allows to define both the attributes common to all science Ph.D graduates, and the specific characteristics engendered by the existence of industrial collaborations. The study of the determinants of the access to employme…

Numerical thermo-mechanical analysis of the DEMO Water-Cooled Lithium Lead breeding blanket conceptual design

Factors Associated with Mortality in Patients Experiencing First Episodes of Acquired Thrombotic Thrombocytopenic Purpura (aTTP). Results of the Span…

2019

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, but life-threatening, hematological disorder characterized by severe thrombocytopenia, hemolytic microangiopathic anemia, and frequent organ damage. The underlying pathophysiology of aTTP is a functional deficiency of plasma ADAMTS13 activity caused by antibodies directed against the ADAMTS13 protease. Despite plasma exchange (PEX) and immunosuppression with corticosteroids, and, more recently, rituximab, which achieve remission in most patients with aTTP, 10-20% of patients are refractory to treatment and die as a result of disease progression. Most of such deaths occur during first episodes of aTTP, as subsequent…