Search results for "fusion"
showing 10 items of 4513 documents
Neuroprotective effect of erythropoietin and darbepoetin alfa after experimental intracerebral hemorrhage.
2009
OBJECTIVE: Intracerebral hemorrhage (ICH) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its long-lasting analog, darbepoetin alfa, have been demonstrated to be neuroprotective in several models of neuronal insult. The objectives of this study were to analyze whether the systemic administration of recombinant human EPO (rHuEPO) and its long-lasting derivative darbepoetin alfa expedited functional recovery and brain damage in a rat model of ICH. METHODS: Experimental ICH was induced in rats by injecting autologous blood into the right striatum under stereotactic guidance. Subsequently, animal…
Dissipative lattice model with exact traveling discrete kink-soliton solutions: Discrete breather generation and reaction diffusion regime
1999
International audience; We introduce a nonlinear Klein-Gordon lattice model with specific double-well on-site potential, additional constant external force and dissipation terms, which admits exact discrete kink or traveling wave fronts solutions. In the nondissipative or conservative regime, our numerical simulations show that narrow kinks can propagate freely, and reveal that static or moving discrete breathers, with a finite but long lifetime, can emerge from kink-antikink collisions. In the general dissipative regime, the lifetime of these breathers depends on the importance of the dissipative effects. In the overdamped or diffusive regime, the general equation of motion reduces to a di…
Recent progress in developing a feasible and integrated conceptual design of the WCLL BB in EUROfusion project
2019
The water-cooled lithium-lead breeding blanket is in the pre-conceptual design phase. It is a candidate option for European DEMO nuclear fusion reactor. This breeding blanket concept relies on the liquid lithium-lead as breeder-multiplier, pressurized water as coolant and EUROFER as structural material. Current design is based on DEMO 2017 specifications. Two separate water systems are in charge of cooling the first wall and the breeding zone: thermo-dynamic cycle is 295–328 °C at 15.5 MPa. The breeder enters and exits from the breeding zone at 330 °C. Cornerstones of the design are the single module segment approach and the water manifold between the breeding blanket box and the back suppo…
Halogen diffusion in a basaltic melt
2007
Abstract The diffusion of the halogens fluorine, chlorine and bromine was measured in a hawaiitic melt from Mt. Etna at 500 MPa and 1.0 GPa, 1250 to 1450 °C at anhydrous conditions; the diffusion of F and Cl in the melt was also studied with about 3 wt% of dissolved water. Experiments were performed using the diffusion-couple technique in a piston cylinder. Most experiments were performed with only one halogen diffusing between the halogen-enriched and halogen-poor halves of the diffusion couple, but a few experiments with a mixture of halogens (F, Cl and Br) were also performed in order to investigate the possibility of interactions between the halogens during diffusion. Fluorine and chlor…
A method of data structuring for the study of diffusion processes of raw materials and manufactured objects
2017
International audience; Workgroup 3 of the ArchaeDyn II programme aims at studying the diffusion systems of products in ancient times. In order to be able to structure data in GIS in an appropriate way, we propose to go through three levels of modelling: the first one aims at gathering together the different components of the diffusion systems taking into account their interactions; the second corresponds to a conceptual data model created with the help of the HBDS method, that will, as we get to the third stage, lead to the creation of a "three-dimensional" geodatabase. Here we point out the fact that the approach through the simple notion of “site” is not sufficient to study the products’…
Techniques to measure sorption and migration between small molecules and packaging. A critical review
2015
The mass transfer parameters diffusion and sorption in food and packaging or between them are the key parameters for assessing a food product's shelf-life in reference to consumer safety. This has become of paramount importance owing to the legislations set by the regulated markets. The technical capabilities that can be exploited for analyzing product–package interactions have been growing rapidly. Different techniques categorized according to the state of the diffusant (gas or liquid) in contact with the packaging material are emphasized in this review. Depending on the diffusant and on the analytical question under review, the different ways to study sorption and/or migration are present…
Inter- and Intramolecular Anodic Nucleophilic Substitutions of Porphyrins. Reactivity of the resulting products
2020
This manuscript presents the functionalization of porphyrins by anodic nucleophilic substitution (SNAn). After an introduction describing generalities on porphyrin, the 2nd chapter deals with the 2-step synthesis of primary aminoporphyrins. The 1st electrochemical step consists in oxidizing the porphyrin at the 1st oxidation potential in the presence of pyridine. The formed pyridinium-porphyrin is then transformed into an amine by opening the pyridinium fragment by nucleophilic attack of piperidine.The 3rd chapter presents the synthesis and redox reactivity of porphyrins substituted with one (or several) aromatic groups carrying an imine function (thiopyrimidine, quinoline and aminopyridine…
Experimental „Luxury Perfusion” in the Cerebral Cortex of the Cat
1968
Publisher Summary Preliminary studies have been performed, on the changes of cortical rCBF (Krypton- 85 Beta clearance technique) in response to a localized pressure applied to the cerebral cortex (suprasylvian gyrus) of 8 cats under Nembutal anesthesia (30 to 40 mg/kg bodyweight). No change in rCBF is found at regions as distant as the contralateral hemisphere. The increase of rCBF at the compressed site, during the compression, seems to be more marked in animals with higher blood (i.e. perfusion) pressure, and may be absent in cats with blood pressure of about 80 mm Hg. The augmentation of rCBF around the compressed area during the compression is always very marked, and after some time fl…
Linfomatosis intravascular de presentación pulmonar
2001
Se presenta un caso de linfomatosis intravascular cuyas primeras manifestaciones clínicas fueron síntomas pulmonares (tos no productiva, hipoxia y patrón radiológico reticulointersticial), seguidas de fiebre de origen desconocido y síndrome confusional. El diagnóstico se obtuvo mediante estudio histológico e inmunohistoquímico postmortem, observándose en el pulmón tabiques alveolares engrosados por la presencia de células atípicas en el interior de los capilares que también ocupaban las luces de pequeños vasos, evidenciándose de forma aislada salida de las mismas al estroma fibroso perivascular y peribronquial. Las técnicas inmunohistoquímicas sobre cortes en parafina revelaron en las célul…
Searching for the right timing of surgical delay: angiogenesis, vascular endothelial growth factor and perfusion changes in a skin-flap model.
2009
Summary Background The angiogenic potential of vascular endothelial growth factor (VEGF) and its oxygen pressure-dependent regulation suggest a strong connection between this growth factor and the ‘delay phenomenon'. In this study we focused on the chronological changes in VEGF concentration and flap perfusion in order to optimise the duration of surgical delay. Methods The VEGF concentration in skin and underlying muscle was measured in oversized, random-pattern flaps on 38 male Sprague-Dawley rats after 3, 5 or 7 days of surgical delay. Additionally, flaps were raised 5 or 7 days past preconditioning. The effect on flap perfusion was measured using indocyanine green fluoroscopy and the si…