Search results for "g15"
showing 10 items of 37 documents
Calibrating Expert Assessments Using Hierarchical Gaussian Process Models
2020
Expert assessments are routinely used to inform management and other decision making. However, often these assessments contain considerable biases and uncertainties for which reason they should be calibrated if possible. Moreover, coherently combining multiple expert assessments into one estimate poses a long-standing problem in statistics since modeling expert knowledge is often difficult. Here, we present a hierarchical Bayesian model for expert calibration in a task of estimating a continuous univariate parameter. The model allows experts' biases to vary as a function of the true value of the parameter and according to the expert's background. We follow the fully Bayesian approach (the s…
ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation
2016
ABSTRACT Human respiratory syncytial virus (RSV), for which neither a vaccine nor an effective therapeutic treatment is currently available, is the leading cause of severe lower respiratory tract infections in children. Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein that is highly increased during viral infections and has been reported to have an antiviral or a proviral activity, depending on the virus. Previous studies from our laboratory demonstrated strong ISG15 upregulation during RSV infection in vitro . In this study, an in-depth analysis of the role of ISG15 in RSV infection is presented. ISG15 overexpression and small interfering RNA (siRNA)-silencing experiments,…
Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates.
2007
Ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) reversibly conjugate to proteins via a conserved LRLRGG C-terminal motif, mediating important innate antiviral responses. The ovarian tumor (OTU) domain represents a superfamily of predicted proteases found in eukaryotic, bacterial and viral proteins, some of which have Ub-deconjugating activity. We show that the OTU domain-containing proteases of nairoviruses and arteriviruses hydrolyze Ub and ISG15 from cellular target proteins. This broad activity contrasts with the target specificity of known mammalian OTU domain-containing proteins. The biological significance of this activity of viral OTU domain-containing proteases was …
Multiplicity of fixed points and growth of ε-neighborhoods of orbits
2012
We study the relationship between the multiplicity of a fixed point of a function g, and the dependence on epsilon of the length of epsilon-neighborhood of any orbit of g, tending to the fixed point. The relationship between these two notions was discovered before (Elezovic, Zubrinic, Zupanovic) in the differentiable case, and related to the box dimension of the orbit. Here, we generalize these results to non-differentiable cases introducing a new notion of critical Minkowski order. We study the space of functions having a development in a Chebyshev scale and use multiplicity with respect to this space of functions. With the new definition, we recover the relationship between multiplicity o…
Planar maps whose second iterate has a unique fixed point
2007
Let a>0, F: R^2 -> R^2 be a differentiable (not necessarily C^1) map and Spec(F) be the set of (complex) eigenvalues of the derivative F'(p) when p varies in R^2. (a) If Spec(F) is disjoint of the interval [1,1+a[, then Fix(F) has at most one element, where Fix(F) denotes the set of fixed points of F. (b) If Spec(F) is disjoint of the real line R, then Fix(F^2) has at most one element. (c) If F is a C^1 map and, for all p belonging to R^2, the derivative F'(p) is neither a homothety nor has simple real eigenvalues, then Fix(F^2) has at most one element, provided that Spec(F) is disjoint of either (c1) the union of the number 0 with the intervals ]-\infty, -1] and [1,\infty[, or (c2) t…
The determinants of increasing equity market comovement: economic or financial integration?
2010
This paper investigates to what extent the substantial increase in exposures of local European equity market returns to global shocks is mainly due to a convergence in cash flows (“economic integration”), to a convergence in discount rates (“financial integration”), or to both. We find that this increased exposure is nearly entirely due to increasing discount-rate betas. This finding is robust to alternative ways of calculating discount-rate and cash-flow shocks.
Assessment of the Insolvency Risk in Companies Listed on the Bucharest Stock Exchange
2019
Abstract The present study presents, from the theoretical and pragmatic point of view, 6 of the established score models regarding the assessment of the insolvency risk, belonging to the Anglo-Saxon, Continental and Romanian schools. The research sample is made up of 26 companies belonging to the hotel industry and restaurants, listed on the Bucharest Stock Exchange. The research was carried out over a period of 11 years (2007-2017). Following the application of the score models, it was found that during the period covered by the research, a number of 14 companies had a relatively high insolvency risk and 12 of them had a relatively low insolvency risk.
Sovereign Credit Ratings and Financial Markets Linkages: Application to European Data
2012
We use EU sovereign bond yield and CDS spreads daily data to carry out an event study analysis on the reaction of government yield spreads before and after announcements from rating agencies (Standard & Poor’s, Moody’s, Fitch). Our results show significant responses of government bond yield spreads to changes in rating notations and outlook, particularly in the case of negative announcements. Announcements are not anticipated at 1–2 months horizon but there is bi-directional causality between ratings and spreads within 1–2 weeks; spillover effects especially among EMU countries and from lower rated countries to higher rated countries; and persistence effects for recently downgraded countrie…
Spreads of bonds issued by sub-sovereign European governments
2017
[EN] This paper identifies the factors that affect the spread of fixed and variable type bonds in the primary and secondary markets issued by sub-sovereign European governments. The analyses of both markets will be done separately to compare whether the determinants in the primary market coincide with those in the secondary market. The analyses will examine the period between February 2008 and December 2013 using data panel estimations. The conclusions are that both markets are approximately identical behavior and the signs of the variables matched what was expected in nearly every case. Also, we concluded that the most important in determining the spread sub-sovereign variable is the sprea…
Globalization of Monitoring Practices: The Case of American Influences on the Dismissal Risk of European CEOs
2013
Accepted version of an article from the Journal of Economics and Business This study examines globalization of monitoring practices by focusing on how American (U.S.) influences on European firms impact the dismissal risk for these firms' CEOs. Specifically, we argue that the stronger short term orientation of the American corporate governance system increase the dismissal performance sensitivity faced by European CEOs, indirectly and directly. The former materializes via European firms cross-listing on U.S. exchanges, the latter results from European firms hiring U.S. independent board members. Both influences are expected to result in increased dismissal performance sensitivity. Based on …