Search results for "ganglio"
showing 10 items of 362 documents
Glaucoma and Antioxidants: Review and Update
2020
Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.
Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks
2021
Pheochromocytoma and paraganglioma are neuroendocrine neoplasms, originating in the adrenal medulla and in parasympathetic and sympathetic autonomic nervous system ganglia, respectively. They usually present as localized tumours curable with surgery. However, these tumours may exhibit heterogeneous clinical course, ranging from no/minimal progression to aggressive (progressive/metastatic) behavior. For this setting of patients, current therapies are unsatisfactory. Immune checkpoint inhibitors have shown outstanding results for several types of solid cancers. We therefore aimed to summarize and discuss available data on efficacy and safety of current FDA-approved immune checkpoint inhibitor…
Neurotrophic effects of central nicotinic receptor activation
2000
A growing number of data have shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have, both in vivo and in vitro, the potential to be neuroprotective and that treatment with nAChR agonists elicit long-lasting improvement of cognitive performance in a variety of behavioural tests in rats, monkeys and humans. Epidemiological and clinical studies suggested also a potential neuroprotective/trophic role of (-)-nicotine in neurodegenerative disease, such as Alzheimer's disease and Parkinson's disease. This neuroprotective/trophic role of nAChR activation has been mainly mediated by alpha7 and alpha4beta2 nAChR subtypes, as evidenced using selective nAChR ant…
Electrocatheter-mediated High-voltage Pulsed Radiofrequency of the Dorsal Root Ganglion in the Treatment of Chronic Lumbosacral Neuropathic Pain
2019
Objectives:Despite the interest in scientific community, there is still poor evidence about pulsed radiofrequency (PRF) efficacy in the treatment of neuropathic pain. In order to determine whether high-voltage PRF and epidural adhesiolysis (PRF-EA) showed better results than epidural adhesiolysis al
Membrane oligo- and polysialic acids
2011
AbstractPolysialic acid (polySia) and oligosialic acid (oligoSia) chains are linear polysaccharides composed of sialic acid monomers. The majority of biological poly/oligoSia chains are bound to membranes. There is a large diversity of membrane poly/oligoSia in terms of chain length, occurrence, biological function, and the mode of membrane attachment. Poly/oligoSia can be anchored to a membrane via a phospholipid (polySia in bacteria), a glycosphingolipid (oligoSia in gangliosides), an integral membrane glycoprotein, or a glycoprotein attached to a membrane via glycosylphosphatidylinositol. In eukaryotic cells, the attachment of a poly/oligoSia chain to the membrane anchor is usually throu…
Cáncer de colon. Estudio de base poblacional de la aplicación de las gráficas de control CUSUM en el análisis del estado ganglionar
2017
INTRODUCCIÓN. En nuestro medio, el cáncer colorrectal es el tumor maligno más frecuentemente diagnosticado en ambos sexos y representa una de las principales causas de muerte por cáncer. La afectación ganglionar se ha relacionado de una manera directa con la supervivencia y con el intervalo libre de enfermedad. El número total de ganglios analizados, incluso en los pacientes con estadio ganglionar pN0, es un demostrado factor pronóstico. Por lo que los nuevos métodos de estadificación ganglionar, cociente ganglionar (LNR) y logaritmo de odds ganglionar (LODDS), pueden ofrecer ventajas respecto a la clasificación TMN para la obtención de subgrupos de riesgo similar. Las gráficas Cumulative S…
A CRF-Producing and -Secreting Tumor of the Lung
1986
Corticotropin-releasing factor (CRF) has recently been isolated from ovine hypothalamus, characterized chemically, and synthesized. Upton and Amatruda (1971) first suggested that CRF-like activity occurred in neoplastic tissues, and Hashimoto et al. (1980) subsequently detected CRF-like activity in an extract of an ACTHproducing nephroblastoma. Recently, Carey et al. (1984) and Asa et al. (1984) used immunocytochemical techniques to demonstrate CRF in postmortem tumor material obtained from patients with a carcinoma of the prostate and an intrasellar gangliocytoma.
Locust neuropeptides stimulating sex pheromone production in female European corn borer moth, Ostrinia nubilalis
1990
Abstract The presence of a pheromonotropically active hormone (PBAN-like substance) from locust organs, ( Locusta migratoria ) has been demonstrated. Extracts of brain, corpora cardiaca, corpora allata, suboesophageal ganglia and thoracic ganglia of L. migratoria caused highly pheromonotropic responses in decapitated females of the European corn borer moth ( Ostrinia nubilalis ). The highest activity per unit weight of tissue was found in the corpora cardiaca and corpora allata of the locust followed by the brain plus suboesophageal ganglion of O. nubilalis . Following 8 days of disconnection, separating the corpora allata from the corpora cardiaca and suboesophageal ganglion, the pheromono…
Trigeminal innervation of the mammalian pineal gland.
1999
There is evidence that the trigeminal (Gasserian) ganglia innervate the mamma- lian pineal gland and serve in its regulation in addition to the sympathetic and cholinergic as well as further influences. By means of immunohistochemical methods, previous studies demonstrated fibers containing calcitonin gene-related peptide (CGRP-LI) or substance P (SP) in the superficial pineal of various mammalian species. In addition, SP and the related tachykinin, neurokinin A, were detected by radioimmunoassay and HPLC, respectively, in the rat and human pineal gland. In the present study, retrograde neuronal tracing upon injection of a tracer substance into the superfical pineal gland of rats was used i…
SENTOV: Técnica del ganglio centinela en el cáncer de ovario inicial (Estadío I-II)
2020
Objetivo: el cáncer de ovario en estadio inicial podría representar una escenario de enfermedad ideal para la aplicación de la técnica de ganglio centinela. Sin embargo, la experiencia publicada es limitada. Nuestro objetivo es evaluar la viabilidad y la seguridad de la biopsia selectiva de ganglio centinela en pacientes con cáncer de ovario en estadio clínico I # II. Métodos: Realizamos un estudio piloto prospectivo con 10 pacientes y un ensayo clínico con 20 pacientes con cáncer de ovario confirmado histológicamente. Como trazadores usamos 99mTc y verde de indocianina que se inyectaron tanto en el útero-ovario y muñón del ligamento infundibulopélvico. Mediante una gamma sonda y un disposi…