Search results for "ganglio"
showing 10 items of 362 documents
Análisis cuantitativa, mediante OCT y Angio-OCT, del grosor coroideo y flujo vascular retiniano y su relación con la capa de fibras nerviosas y célul…
2021
El objetivo principal fue evaluar si existen cambios vasculares, en el grosor coroideo o en la densidad vascular macular, en pacientes con esclerosis múltiple (EM) respecto a controles sanos. Los objetivos secundarios fueron: determinar si existen diferencias vasculares basales según el grado de discapacidad; estudiar si los cambios vasculares se correlacionan con las diferencias de espesor de las capas de fibras nerviosas peripapilares (RNFLno), maculares (RNFLmac) y células ganglionares (GCL);analizar si a lo largo de un año existen cambios vasculares así como cambios anatómicos en los pacientes con EM;comparar el grosor coroideo y la densidad vascular entre pacientes con o sin presencia …
Spatial and temporal pattern of neuroblasts, proliferation, and Engrailed expression during early brain development in Tenebrio molitor L. (Coleopter…
2003
Abstract In insects, the knowledge of embryonic brain development is still fragmentary, and comparative data are scarce. In this study, we explored aspects of embryonic brain development in the coleopteran Tenebrio molitor . A detailed description is provided of the spatial and temporal pattern of the embryonic brain neuroblasts during 18–60% of embryonic development. Approximately 125 brain NBs have been identified in each hemisphere of the brain at about 40% of embryonic development. A subset of five neuroblasts, among them the two progenitors of the mushroom bodies and two progenitors of the larval antennal lobe, are morphologically identifiable by their larger size. As revealed by incor…
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
2011
http://www.sciencedirect.com/; International audience; Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function, highlighting the crucial importance of maintaining cholesterol homeostasis in the retina. Our purpose was to give a review on the functioning of the retina, the role of cholesterol and cholesterol metabolism therein, with special emphasis on cholesterol-24S-hydroxylase (CYP46A1). Similar to th…
In vivo consequences of cholesterol-24s-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina
2011
Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences of CYP46A1 inhibition by voriconazole on cholesterol homeostasis and function in the retina. Rats received daily intraperitoneal injections of voriconazole (60mg/kg), minocycline (22mg/kg), voriconazole plus minocycline, or vehicle during five consecutive days. The rats were submitted to electroretinography to monitor retinal functionality. Cholesterol and 24S-hydroxycholesterol were measured in plasma, brain and retina by gas chromatography-mass spectrometry. T…
Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma U…
2020
The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inf…
Nerve Root and Types of Needles Used in Transforaminal Injections
2014
The use of transforaminal epidural injections of steroids is common practice in pain medicine, in patients with radicular pain resistant to conventional treatments such as physiotherapy or anti-inflammatory medications. The goal of these injections is to deposit steroids in the proximity of nerve roots, using the epidural or the transforaminal route. The procedure is performed using a translaminar, caudal, or transforaminal approach.
Antibodies to cell surface ganglioside GD3 perturb inductive epithelial-mesenchymal interactions
1988
Abstract Most epithelial sheets emerge during embryogenesis by a branching and growth of the epithelium. The surrounding mesenchyme is crucial for this process. We report that branching morphogenesis and the formation of a new epithelium from the mesenchyme in the embryonic kidney can be blocked by a monoclonal antibody reacting with a surface glycolipid, disialoganglioside G D3 . In contrast, a more than 10-fold excess of antibodies to adhesive glycoproteins (N-CAM, L -CAM, fibronectin) fails to inhibit morphogenesis. Although the anti-G D3 antibody affected epithelial development, the disialoganglioside G D3 was expressed not in the epithelium, but in the mesenchyme surrounding the develo…
7-O-acetyl-GD3 in human T-lymphocytes is detected by a specific T-cell-activating monoclonal antibody.
1995
The monoclonal antibody U5, which is a potent inducer of proliferation in human T-cells, was found to bind to an alkali-sensitive derivative of ganglioside GD3. Using immunochemical and spectroscopic methods, the structure of the U5 antigen was determined as 7-O-acetyl-GD3. The antibody U5 did not react with 9-O-acetyl-GD3 and bound severalfold more stronger to 7-O-acetyl-GD3 than to GD3. U5 is the first antibody known to detect preferentially 7-O-acetyl-GD3. Flow cytometric analysis showed that each major class of human leukocytes contained a significant fraction of cells binding the U5 antibody.
Technical and surgical aspects of the sphenopalatine ganglion (SPG) microstimulator insertion procedure
2015
Cluster headache (CH) is a debilitating, severe form of headache. A novel non-systemic therapy has been developed that produces therapeutic electrical stimulation to the sphenopalatine ganglion (SPG). A transoral surgical technique for inserting the Pulsante SPG Microstimulator into the pterygopalatine fossa (PPF) is presented herein. Technical aspects include detailed descriptions of the preoperative planning using computed tomography or cone beam computed tomography scans for presurgical digital microstimulator insertion into the patient specific anatomy and intraoperative verification of microstimulator placement. Surgical aspects include techniques to insert the microstimulator into the…
Waste not, want not: Report of a completely calcified C1-C2 juxtafacet cyst and literature review
2021
Background: Calcified juxtafacet cysts in the cervical spine are extremely rate. Such symptomatic cysts commonly cause neck pain, radiculopathy, or even myelopathy. MR and CT studies typically document cord/ root compression. On occasion, some of these cysts will spontaneously regress, while many others may warrant surgical removal. Case Description: A 70-year-old male presented with a 2-year history of a progressive tetraparesis. The preoperative MR/CT studies showed a C1-C2 left extradural mass occupying more than half of the spinal canal. On MR, it was homogeneously hypointense on both T1- and T2-weighted images, while the CT showed a calcified cyst. Intraoperative and histopathological…