Search results for "ganglio"
showing 10 items of 362 documents
Sphenopalatine ganglion (SPG) neurostimulator placement for treatment of severe headaches using a trans-oral posterior maxillary approach
2013
Dystroglycan regulates structure, proliferation and differentiation of neuroepithelial cells in the developing vertebrate CNS.
2007
AbstractIn the developing CNS α- and β-dystroglycan are highly concentrated in the endfeet of radial neuroepithelial cells at the contact site to the basal lamina. We show that injection of anti-dystroglycan Fab fragments, knockdown of dystroglycan using RNAi, and overexpression of a dominant-negative dystroglycan protein by microelectroporation in neuroepithelial cells of the chick retina and optic tectum in vivo leads to the loss of their radial morphology, to hyperproliferation, to an increased number of postmitotic neurons, and to an altered distribution of several basally concentrated proteins. Moreover, these treatments also altered the oriented growth of axons from retinal ganglion c…
Validación de la biopsia selectiva de ganglio centinela como método de estadificación axilar postneoadyuvancia en pacientes con cáncer de mama y axil…
2021
La biopsia selectiva de ganglio centinela (BSGC) es la técnica de elección para la estadificación axilar en pacientes con cáncer de mama que no reciben tratamiento neoadyuvante (NA), así como en aquellas con axila negativa (N0) al diagnóstico que reciben NA. En pacientes con afectación axilar al diagnóstico (N+) que reciben NA, la realización de BSGC todavía sigue generando debate, debido fundamentalmente a la mayor tasa de falsos negativos (TFN) reportada en los primeros estudios realizados, recomendando todavía la mayoría de guías actuales la realización de linfadenectomía axilar (LA). Algunos procedimientos recientemente descritos, como el marcaje del ganglio inicialmente afecto y su loc…
Korelācija starp obstruktīvās miega apnojas sindromu un nearterītisku išēmisku priekšējo optisko neiropātiju
2021
Darba mērķis: Novērtēt obstruktīvās miega apnojas sindroma (OSAS) pacientus uz nearterītisku išēmisku priekšējo optisko neiropātiju (NAION). Novērtēt OSAS saistību ar peripapilārās tīklenes nervu šķiedru slāni (RNFL) un peripapilāro ganglionāro šūnu slāni-iekšējo tīklaino slāni (GCL-IPL). Metode: RNFL un GCL-IPL mērījumi tika veikti ar OCT. Rezultāti tika salīdzināti starp kontroles un OSAS grupām. Rezultāti: Nevienam no dalībniekiem netika atrasts NAION. Starp pētāmo grupu peripapilārā RNFL vai GCL-IPL biezumu netika novērota statistiska nozīme (p>0,05). Korelācija netika novērota starp AHI un RNFL vai GCL-IPL biezumu. Secinājumi: Peripapilārā RNFL un GCL-IPL neuzrādīja nozīmīgu atšķirību …
[177Lu]Lu-DOTA-TATE and [131I]MIBG Phenotypic Imaging-Based Therapy in Metastatic/Inoperable Pheochromocytomas and Paragangliomas: Comparative Result…
2022
PurposeThe aim of the study is to assess phenotypic imaging patterns and the response to treatment with [177Lu]Lu-DOTA-TATE and/or [131I]MIBG in paragangliomas (PGLs) and pheochromocytomas (PHEOs), globally and according to the primary location.MethodsThis is a 17-patient retrospective observational study, with 9 cases treated with [177Lu]Lu-DOTA-TATE and 8 with [131I]MIBG (37 total treatments). Functional imaging scans and treatment responses were studied in order to choose the best therapeutic option and to define the progression-free survival (PFS) and disease control rate (DCR) according to treatment modality and primary location.ResultsAll patients were studied with phenotypic nuclear …
Factores radiológicos predictivos de accesibilidad quirúrgica a la fosa pterigopalatina
2020
La fosa pterigopalatina es una pequeña región anatómica con forma de pirámide invertida, localizada a caballo entre la base del cráneo y el macizo facial. Es un espacio pequeño y estrecho, estructuralmente complicado y de difícil accesibilidad quirúrgica. En la fosa se aloja el ganglio esfenopalatino, que está implicado en una amplia variedad de enfermedades relacionadas con el dolor facial de origen neurovegetativo, como la cefalea en racimos. La reciente aparición de técnicas basadas en la neuromodulación del ganglio esfenopalatino para el tratamiento de cefaleas en racimo refractarias hace imprescindible profundizar en el conocimiento de la fosa pterigopalatina y de sus vías de acceso. E…
4812 - A0028 Gangliosides in the retina: a comparative inventory with brain and other ocular structures
2016
Purpose: Gangliosides (GG) make an extremely diverse family of glycosphingolipids particularly abundant in the brain and neural tissues. While it is known that alterations in GG metabolism are associated with visual defects, the precise biological roles of these compounds in the retina are still largely unknown. In this context, we performed an exhaustive inventory and thorough characterization of the human eye GG aiming to reveal specificities and common features of the retina compared to other ocular tissues and brain.Methods: Retina, RPE/Choroid, ciliary body, optic nerve and brain samples were collected from deceased human donors (N=7). GG were extracted and analysed by a comprehensive …
Effect of dietary omega-3 and omega-6 fatty acids on IOP elevation, electroretinographic changes and retinal ganglion cell loss in a laser-induced ra…
2008
International audience; Purpose:To test the efficacy of dietary omega-3 and omega-6 fatty acids in a rat model of glaucoma induced by laser photocoagulation.Methods:Male Sprague Dawley rats were fed for 3 months with a diet containing either: 1) 17% of omega-3 fatty acids (10% EPA + 7% DHA), 2) 10% of omega-6 fatty acids (as GLA), or 3) a combination of both omega-3 and omega-6 fatty acids (10% EPA + 7% DHA + 10% GLA), by comparison with a control group of animals fed with a standard diet deprived of EPA, DHA and GLA (n=10 in each group). After 3 months of diet, glaucoma was induced in one eye of each animal by laser photocoagulation (532nm) of the episcleral veins, the trabeculum and the l…
Retinal abnormalities in multiple sclerosis patients with associated chronic cerebrospinal venous insufficiency
2012
Optical coherence tomography (OCT) is a non-invasive method for the assessment of optic nerve fibers and retinal ganglion cells. This study was aimed at the assessment of retinal abnormalities in multiple sclerosis patients in the context of chronic cerebrospinal venous insufficiency using OCT of the retina and the optic nerve. We examined 239 multiple sclerosis (MS) patients, including 220 patients with associated chronic cerebrospinal venous insufficiency and 19 MS patients without venous pathology. The following OCT parameters were assessed: average ganglion cell complex thickness, global loss volume, focal loss volume and average retinal nerve fibre layer thickness. Abnormalities in the…
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…