Search results for "gap"
showing 10 items of 1144 documents
Laser-assisted narrow gap arc welding of an 18MND5 steel thick plate
2020
Abstract Narrow gap arc welding is a common solution for the welding of thick structures. In this study, a defocused laser beam is used to pre-melt the narrow gap walls in front of an arc-welding bath. Such a welding configuration can be referred to a hybrid welding configuration. In the present work, a particular attention is given to evaluation of the interaction between an arc plasma and a defocused laser beam. High-speed imaging of the metal transfer through arc plasma is achieved thanks to a diode laser illumination system. Electrical arc parameters are logged, synchronously, in order to perform a correlation analysis and to make a diagnosis of the interaction level between laser beam …
Parallel distributed compensation for voltage controlled active magnetic bearing system using integral fuzzy model
2018
Parallel Distributed Compensation (PDC) for current-controlled Active Magnetic Bearing System (AMBS) has been quite effective in recent years. However, this method does not take into account the dynamics associated with the electromagnet. This limits the method to smaller scale applications where the electromagnet dynamics can be neglected. Voltage-controlled AMBS is used to overcome this limitation but this comes with serious challenges such as complex mathematical modelling and higher order system control. In this work, a PDC with integral part is proposed for position and input tracking control of voltage-controlled AMBS. PDC method is based on nonlinear Takagi-Sugeno (T-S) fuzzy model. …
Towards Shipping 4.0. A preliminary gap analysis
2020
Abstract The paradigm of Industry 4.0 involves a substantial innovation to the value creation approach thought the supply chain and the application of digital enabling technologies like the Internet of Things (IoT), Big Data Analytics (BDA) and cloud computing. The fourth industrial revolution is thus expected to have a disruptive impact on maritime transport and shipping sectors, where smart ships and autonomous vessels well be part of a new and fully interconnected maritime ecosystem. Specific hardware components, such as sensors, actuators, or processors will be embedded in the ship’s key systems in order to provide valuable information to increase the efficiency, sustainability and safe…
Visualization of Simulated Arrhythmias due to Gap Junctions
2018
New computational models are able to simulate details of cardiac cell networks. Their results allow a better understanding of the functionality of the heart and suggest possible actions to reduce non-fatal premature beats that can give rise to serious diseases. We developed a user-friendly interface to organize Neuron simulations and to present in real-time a three-dimensional representation of the electrical activity due to the gap junctions which interconnect the cells inside cardiac tissues. All physiological parameters were set according to real experimental observations and compared against different types of arrhythmias, retrieved from the Physionet Data Base.
EvalMSA: A Program to Evaluate Multiple Sequence Alignments and Detect Outliers
2016
8 páginas, 3 figuras, 2 tablas.
GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks.
2017
The electrical activity of the brain arises from single neurons communicating with each other. However, how single neurons interact during early development to give rise to neural network activity remains poorly understood. We studied the emergence of synchronous neural activity in human pluripotent stem cell (hPSC)-derived neural networks simultaneously on a single-neuron level and network level. The contribution of gamma-aminobutyric acid (GABA) and gap junctions to the development of synchronous activity in hPSC-derived neural networks was studied with GABA agonist and antagonist and by blocking gap junctional communication, respectively. We characterized the dynamics of the network-wide…
Bioelectrical Signals and Ion Channels in the Modeling of Multicellular Patterns and Cancer Biophysics
2016
AbstractBioelectrical signals and ion channels are central to spatial patterns in cell ensembles, a problem of fundamental interest in positional information and cancer processes. We propose a model for electrically connected cells based on simple biological concepts: i) the membrane potential of a single cell characterizes its electrical state; ii) the long-range electrical coupling of the multicellular ensemble is realized by a network of gap junction channels between neighboring cells; and iii) the spatial distribution of an external biochemical agent can modify the conductances of the ion channels in a cell membrane and the multicellular electrical state. We focus on electrical effects …
Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana
2018
Abstract Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol(3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1–4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and …
Strategies for structuring interdisciplinary education in Systems Biology: an European perspective
2016
Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins, molecules, cells and organisms. The approach aims at elucidating how these interactions govern biological function by employing experimental data, mathematical models and computational simulations. As Systems Biology is inherently multidisciplinary, education within this field meets numerous hurdles including departmental barriers, availability of all required expertise locally, appropriate teaching material and example curricula. As university education at the Bachelor’s level is traditionally built upon…
Complexity of gap junctions between horizontal cells of the carp retina.
2016
In the vertebrate retina, horizontal cells (HCs) reveal homologous coupling by gap junctions (gj), which are thought to consist of different connexins (Cx). However, recent studies in mouse, rabbit and zebrafish retina indicate that individual HCs express more than one connexin. To provide further insights into the composition of gj connecting HCs and to determine whether HCs express multiple connexins, we examined the molecular identity and distribution of gj between HCs of the carp retina. We have cloned four carp connexins designated Cx49.5, Cx55.5, Cx52.6 and Cx53.8 with a close relationship to connexins previously reported in HCs of mouse, rabbit and zebrafish, respectively. Using in s…