Search results for "gate"

SYNTHESIS, CHARACTERIZATION AND IN VITRO CYTOTOXICITY STUDIES OF A MACROMOLECULAR CONJUGATE OF PACLITAXEL BEARING OXYTOCIN AS TARGETING MOIETY.

2007

The present study describes the experimental synthetic procedure and the characterization of a new polyaspartamide macromolecular prodrug of paclitaxel, bearing oxytocin residues as targeting moieties. In vitro stability studies of bioconjugate, performed in media mimicking biological fluids (buffer solutions at pH 7.4 and 5.5) and in human plasma, evidenced the high stability of the targeting portion (oxytocin)-polymer linkage and the ability of this conjugate to release linked paclitaxel in a prolonged way in plasma. Moreover, preliminary in vitro antiproliferative studies, carried out on MCF-7 cells, that are oxytocin receptor positive cells, showed that the polymeric conjugate has the s…

A method for the time-varying nonlinear prediction of complex nonstationary biomedical signals

2009

A method to perform time-varying (TV) nonlinear prediction of biomedical signals in the presence of nonstationarity is presented in this paper. The method is based on identification of TV autoregressive models through expansion of the TV coefficients onto a set of basis functions and on k -nearest neighbor local linear approximation to perform nonlinear prediction. The approach provides reasonable nonlinear prediction even for TV deterministic chaotic signals, which has been a daunting task to date. Moreover, the method is used in conjunction with a TV surrogate method to provide statistical validation that the presence of nonlinearity is not due to nonstationarity itself. The approach is t…

Milk quality as affected by grazing time of day in Mediterranean goats.

2008

We evaluated the effect of grazing time of day on goat milk chemical composition, renneting properties and milk fatty acid profile in a Mediterranean grazing system. Sixteen lactating Girgentana goats were divided into two experimental groups and housed in individual pens, where they received 500 g/d of barley grain. For 5 weeks the two groups were left to graze in two fenced plots on a ryegrass sward as follows: morning group (AM), from 9·00 to 13·00; afternoon group (PM), from 12·00 to 16·00. In selected herbage, water-soluble carbohydrates (WSC) increased in the afternoon (204 v. 174 g/kg dry matter, DM; P=0·01), whereas crude protein (CP) and linolenic acid decreased (respectively, 16·7…

A thin layer-based amperometric enzyme immunoassay for the rapid and sensitive diagnosis of respiratory syncytial virus infections

2012

Abstract A simple electrochemical sandwich immunoassay involving a polystyrene microarray slide coated with monoclonal capture antibodies and carbon screen-printed sensors (SPS) was designed for the rapid diagnosis of respiratory syncytial virus (RSV). The detection of the antibody-antigen complex formation relied on the use of a horseradish peroxidase conjugate. Its chronoamperometric measurement detection was performed by confining a droplet of H 2 O 2 /3,3',5,5'-tetramethylbenzidine enzyme substrate/mediator solution within a thin layer between one spot of the microarray and the surface of one screen-printed electrochemical cell. The accumulation of the enzyme product in the thin film of…

An analytical solution for multilayered beams subjected to ends loads

2014

An alternative model for multilayered beams undergoing axial, shear and bending loads applied at the beam's ends is developed. It is based on a layer-wise kinematics, which inherently fulfills the equilibrium equations at layer level and the interface continuity conditions. This kinematics is suitably expressed by introducing a set of generalized variables representative of the beam midline displacement field, which become the primary variables of the problem governing equations. As a consequence, the proposed beam model exhibits the computational characteristics of an equivalent single layer model and possesses the accuracy of layer-wise beam theories, as well. Closed form solutions for di…

A simple timestamping data acquisition system for ToF-ERDA

2015

A new data acquisition system, ToF-DAQ, has been developed for a ToF-ERDA telescope and other ToF-E and ToF-ToF measurement systems. ToF-DAQ combines an analogue electronics front-end to asynchronous time stamped data acquisition by means of a FPGA device. Coincidences are sought solely in software based on the timestamps. Timestamping offers more options for data analysis as coincidence events can be built also in offline analysis. The system utilises a National Instruments R-series FPGA device and a Windows PC as a host computer. Both the FPGA code and the host software were developed using the National Instruments LabVIEW graphical programming environment. Up to eight NIM ADCs can be han…

Time-of-flight - Energy spectrometer for elemental depth profiling - Jyväskylä design

2014

Abstract A new time-of-flight elastic recoil detection spectrometer has been built, and initially the main effort was focused in getting good timing resolution and high detection efficiency for light elements. With the ready system, a 154 ps timing resolution was recorded for scattered 4.8 MeV 4 He 2+ ions. The hydrogen detection efficiency was from 80% to 20% for energies from 100 keV to 1 MeV, respectively, and this was achieved by having an additional atomic layer deposited Al 2 O 3 coating on the first timing detector’s carbon foil. The data acquisition system utilizes an FPGA-card to time-stamp every time-of-flight and energy event with 25 ns resolution. The different origins of the ba…

Improvement of time-of-flight spectrometer for elastic recoil detection analysis

2013

Three-Dimensional Surface Display in Blood Pool Gated SPECT

1994

In 14 patients (4 in good health and 10 with coronary heart disease) a blood pool gated single photon emission computed tomography (SPECT) was executed. The transaxial slices of the cardiac blood pool were reconstructed. A three-dimensional surface display was employed for the analysis of the tomographic data. A fixed distance, a fixed threshold (50%), and some different planes of view were employed. The test permitted visualiza tion of the ventricular and the atrial movements in all patients. The right ventricle was clearly seen in the right anterior oblique plane of view. The aortic beating was seen. In normal patients the left ventricle, clearly seen in left anterior oblique plane, shra…

Organic carbon, water repellency and soil stability to slaking under different crops and managements: a case study at aggregate and intra-aggregate s…

2014

This research studies the distribution of organic C and intensity of water repellency in soil aggregates with different size and in the interior of aggregates from Mediterranean soils under different crops (apricot, citrus and wheat) and management (con- 5 ventional tilling and no tilling/mulching). For this, undisturbed aggregates were sampled and carefully divided in size fractions (0.25–0.5, 0.5–1, 1–2, 2–5, 5–10 and 10–15 mm) or peeled to obtain separated aggregate layers (exterior, transitional and interior). Organic C content in the fine earth fraction of soils under different crops did not show important variations, although it increased significantly from conventionally tilled to 10…