Search results for "gate"

Effet anti-obésité des CLA : mythe ou réalité ?

2005

Conjugated linoleic acids (CLA) are positional and geometric isomers of linoleic acid. Inclusion of CLA in the diet provokes a rapid and marked decrease in body weight gain and adiposity in mice leading to a lipoatrophic syndrome. However, CLA supplementation raised fasting blood glucose and insulin concentrations and was associated with severe insulin resistance and liversteatosis. Conflicting results have been reported with regard to reduction of fat mass in humans. We have reviewed the publish literature regarding the effect of CLA on body composition in humans and animal models. These studies indicate that t10-c12 was the isomer that reduced adipose fat storage, however it also increase…

Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.

2021

[EN] Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C. auris is highly desired; nevertheless, current methods often present severe limitations and produce misidentification. Herein a sensitive, selective, and time-competitive biosensor based on oligonucleotide-gated nanomaterials for effective detection of C. auris is presented. In the proposed design, a nanoporous anodic alumina scaffold is filled with the fluorescent indicator rhodamine B and the pores blocked with different oligonucleotides capable of specifically recognize C. auris genomic DNA. Gate opening modul…

ResearchGate vai julkaisuarkisto – vai molemmat?

2016

Developing a Method for Measuring Science and Technology Oriented Creativity (STOC)

2021

Abstract The article contains the results of a research within the STIMEY (Science, Technology, Innovation, Mathematics, Engineering for the Young) project funded by the European Union’s Horizon-2020 research and innovation program (2016-2021). In the project, a hybrid learning environment (LE) was developed for both on-site and online learning suitable for the learning conditions in the COVID-19 era and beyond. The purpose of the research segment presented in this paper was to develop an instrument for assessment of the learner’s progress in creativity as one of the key targets of STIMEY. COVID-19 has shown that creativity is also needed to allow education systems the flexibility for unexp…

Synergistic photo-release of drugs by non-linear excitation

2014

ABSTRACTNanomaterials engineered in novel multi-modular systems in which every component works in a synergistic way with others could potentially lead to a completely new type of tools for nanomedicine. The development of nanostructures able to release drugs directly within the target after a stimulus can drastically improve the therapeutics efficiency by reducing side effects. Gold nanoparticles offer one of the most suitable platforms for the development of modular nano-devices. On the one hand, their surface properties enable effective coating by peptides containing at least one cysteine, thus yielding stable and non-cytotoxic systems. On the other, their intriguing photophysics, charact…

Surrogate-assisted multicriteria optimization: Complexities, prospective solutions, and business case

2017

Complexity in solving real-world multicriteria optimization problems often stems from the fact that complex, expensive, and/or time-consuming simulation tools or physical experiments are used to evaluate solutions to a problem. In such settings, it is common to use efficient computational models, often known as surrogates or metamodels, to approximate the outcome (objective or constraint function value) of a simulation or physical experiment. The presence of multiple objective functions poses an additional layer of complexity for surrogate-assisted optimization. For example, complexities may relate to the appropriate selection of metamodels for the individual objective functions, extensive …

ANTIBODY-DRUG CONJUGATES: A SYSTEMATIC REVIEW OF IN VITRO STUDIES IN ORAL CANCER

2021

Suite of Statistical Models Forecasting Latvian GDP

2014

Abstract We develop a suite of statistical models to forecast Latvian GDP. We employ various univariate and multivariate econometric techniques to obtain short-term GDP projections and to assess the performance of the models. We also comprise the information contained in components of GDP and obtain short-term GDP projections from disaggregated perspective. We run out-of-sample forecasting procedures to evaluate GDP projections and to assess forecasting accuracy of all individual statistical models. We conclude that factor and bridge models are among the best individually performing models in the suite. Forecasting accuracy obtained using disaggregated models of factor and bridge models is …

Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer

2021

Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…

Prevalence of Pneumococcal Serotypes in Community-Acquired Pneumonia among Older Adults in Italy: A Multicenter Cohort Study

2022

Pneumococcal community-acquired pneumonia (CAP) is a leading cause of mortality. Following the introduction of pneumococcal conjugate vaccines (PCVs) in children, a decrease in the burden of the disease was reported. In parallel, an increase in non-vaccine serotypes was also noted. The objective of this study was to assess the current serotype-specific epidemiology of pneumococci among Italian older adults hospitalized for CAP. A prospective study was conducted between 2017 and 2020 in four Italian regions. Subjects aged ≥65 years hospitalized with confirmed CAP were tested for pneumococci using both pneumococcal urinary antigen and serotype-specific urine antigen tests able to identify all…