Search results for "generation"
showing 10 items of 3050 documents
District heating networks: enhancement of the efficiency
2019
International audience; During the decades the district heating's (DH) advantages (more cost-efficient heat generation and reduced air pollution) overcompensated the additional costs of transmission and distribution of the centrally produced thermal energy to consumers. Rapid increase in the efficiency of low-power heaters, development of separated low heat density areas in cities reduce the competitiveness of the large centralized DH systems in comparison with the distributed cluster-size networks and even local heating. Reduction of transmission costs, enhancement of the network efficiency by optimization of the design of the DH networks become a critical issue. The methodology for determ…
High quality conservative surface mesh generation for swept volumes
2012
We present a novel, efficient and flexible scheme to generate a high quality mesh that approximates the outer boundary of a swept volume. Our approach comes with two guarantees. First, the approximation is conservative, i.e., the swept volume is enclosed by the generated mesh. Second, the one-sided Hausdorff distance of the generated mesh to the swept volume is upper bounded by a user defined tolerance. Exploiting this tolerance the algorithm generates a mesh that is adapted to the local complexity of the swept volume boundary, keeping the overall output complexity remarkably low. The algorithm is two-phased: the actual sweep and the mesh generation. In the sweeping phase we introduce a gen…
Detection of algorithmically generated malicious domain names using masked N-grams
2019
Abstract Malware detection is a challenge that has increased in complexity in the last few years. A widely adopted strategy is to detect malware by means of analyzing network traffic, capturing the communications with their command and control (C&C) servers. However, some malware families have shifted to a stealthier communication strategy, since anti-malware companies maintain blacklists of known malicious locations. Instead of using static IP addresses or domain names, they algorithmically generate domain names that may host their C&C servers. Hence, blacklist approaches become ineffective since the number of domain names to block is large and varies from time to time. In this paper, we i…
Uncovering Technological and Environmental Potentials of Aluminum Alloy Scraps Recycling Through Friction Stir Consolidation
2020
Conventional metal chips recycling processes are energy-intensive with low efficiency and permanent material losses during re-melting. Solid state recycling allows direct recycling of metal scraps into semi-finished products. It is expected that this process category would lower the environmental performance of metals recycling. Friction Stir Consolidation is a new solid-state technique taking advantage of friction heat generation and severe plastic deformation to consolidate chips into billets. In this research, the feasibility of Friction Stir Consolidation as aluminum chips recycling process is analyzed. Specifically, an experimental campaign has been carried out with varying main proces…
Il neonato che “sa di sale”
2021
Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease due to the peripheral resistance to aldosterone. Clinical spectrum with neonatal onset includes salt loss, hyponatremia, hypochloraemia, hyperkalaemia, metabolic acidosis and increased plasmatic levels of aldosterone. Two forms of the disease - renal and systemic – have been described, which are genetically distinct and with wide clinical expressivity. The most severe generalized PHA1 is caused by mutations in the genes encoding for the subunits of the epithelial sodium channels (ENaC). The paper reports the case of a newborn of the first pregnancy of healthy and consanguineous Sicilian parents, with a clinical and hormonal pic…
Intergenerational differences in the body build of women
2019
Background: This study analyzed generational differences in body build of woman. Aim of the study: The aim of the study was to examine the intergenerational differences in the body build of women. Material and methods: 90 women (30 female physiotherapy students, their mothers and grandmothers) were examined. Their heights, weights, waist circumferences, and waist and hip circumferences were measured. Their Body mass index (BMI) and Waist to Hip Ratio (WHR) were calculated. Their frequency of underweight, overweight and obesity were estimated. WHO criteria were applied. The results were subjected to statistical analysis. Descriptive statistics were calculated. The Shapiro-Wilk test for testi…
Lens regeneration in children.
2018
Functions of histone modifications and histone modifiers in Schwann cells.
2019
Schwann cells (SCs) are the main glial cells present in the peripheral nervous system (PNS). Their primary functions are to insulate peripheral axons to protect them from the environment and to enable fast conduction of electric signals along big caliber axons by enwrapping them in a thick myelin sheath rich in lipids. In addition, SCs have the peculiar ability to foster axonal regrowth after a lesion by demyelinating and converting into repair cells that secrete neurotrophic factors and guide axons back to their former target to finally remyelinate regenerated axons. The different steps of SC development and their role in the maintenance of PNS integrity and regeneration after lesion are c…
Human ectonucleotidase-expressing CD25 high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions
2015
IF 7.644; International audience; Th17 cells contribute to the development of some autoimmune and allergic diseases by driving tissue inflammation. However, the function of Th17 cells during cancer progression remains controversial. Here, we show that human memory CD25(high) Th17 cells suppress T cell immunity in breast cancer. Ectonucleotidase-expressing Th17 cells accumulated in breast cancer tumors and suppressed CD4(+) and CD8(+) T cell activation. These cells expressed both Ror gamma t and Foxp3 genes and secreted Th17 related cytokines. We further found that CD39 ectonucleotisase expression on tumor-infiltrating Th17 cells was driven by TGF-beta and IL-6. Finally, immunohistochemical …
What is the impact of a novel MED12 variant on syndromic conotruncal heart defects? Analysis of case report on two male sibs
2020
Abstract Background Syndromic congenital heart disease accounts for 30% of cases and can be determined by genetic, environmental or multifactorial causes. In many cases the etiology remains uncertain. Many known genes are responsible for specific morphopathogenetic mechanisms during the development of the heart whose alteration can determine specific phenotypes of cardiac malformations. Case presentation We report on two cases of association of conotruncal heart defect with facial dysmorphisms in sibs. In both cases the malformations’ identification occurred by ultrasound in the prenatal period. It was followed by prenatal invasive diagnosis. The genetic analysis revealed no rearrangements …