Search results for "generi"
showing 10 items of 125 documents
Biosimilar and generic formulations of novel antidiabetic drugs: the role of liraglutide in clinical pharmacology of type 2 diabetes.
2022
Defining relations of minimal degree of the trace algebra of 3×3 matrices
2008
Abstract The trace algebra C n d over a field of characteristic 0 is generated by all traces of products of d generic n × n matrices, n , d ⩾ 2 . Minimal sets of generators of C n d are known for n = 2 and n = 3 for any d as well as for n = 4 and n = 5 and d = 2 . The defining relations between the generators are found for n = 2 and any d and for n = 3 , d = 2 only. Starting with the generating set of C 3 d given by Abeasis and Pittaluga in 1989, we have shown that the minimal degree of the set of defining relations of C 3 d is equal to 7 for any d ⩾ 3 . We have determined all relations of minimal degree. For d = 3 we have also found the defining relations of degree 8. The proofs are based …
Interpolation and approximation in L2(γ)
2007
Assume a standard Brownian motion W=(W"t)"t"@?"["0","1"], a Borel function f:R->R such that f(W"1)@?L"2, and the standard Gaussian measure @c on the real line. We characterize that f belongs to the Besov space B"2","q^@q(@c)@?(L"2(@c),D"1","2(@c))"@q","q, obtained via the real interpolation method, by the behavior of a"X(f(X"1);@t)@[email protected]?f(W"1)-P"X^@tf(W"1)@?"L"""2, where @t=(t"i)"i"="0^n is a deterministic time net and P"X^@t:L"2->L"2 the orthogonal projection onto a subspace of 'discrete' stochastic integrals x"[email protected]?"i"="1^nv"i"-"1(X"t"""i-X"t"""i"""-"""1) with X being the Brownian motion or the geometric Brownian motion. By using Hermite polynomial expansions the…
Frontiers of metal-coordinating drug design
2020
INTRODUCTION: The occurrence of metal ions in biomolecules is required to exert vital cellular functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors targeting their metal-moiety. As well, the discovery of cisplatin ushered the rational discovery of metal-containing-drugs. The use of both drug types exploiting metal–ligand interactions is well established to treat distinct pathologies. Therefore, characterizing and leveraging metal-coordinating drugs is a pivotal, yet challenging, part of medicinal chemistry. AREA COVERED: Atomic-level simulations are increasingly employed to overcome the challenges met by traditional drug-discovery approaches and to compleme…
Patterns and trends in scientific research on generic drugs
2016
[Purpose]: The purpose of this study to investigate the evolution and current status of peer-reviewed publications concerning generic drugs during the past few decades. [Methods]: Scientific articles about generic drugs published until 2012 were retrieved through the PubMed/MEDLINE database, and a content analysis was performed. [Findings]: Our study revealed an increasing number of publications on generics since 1984. Statins, antiretroviral therapies, and antiepileptics, followed by immunosuppressants and antithrombotic agents, were the most common therapeutic drug categories. [Implications]: Almost 60% of the generics detailed in studies indexed in MEDLINE were acting on the cardiovascul…
Compensation of missing wedge effects with sequential statistical reconstruction in electron tomography.
2014
Electron tomography (ET) of biological samples is used to study the organization and the structure of the whole cell and subcellular complexes in great detail. However, projections cannot be acquired over full tilt angle range with biological samples in electron microscopy. ET image reconstruction can be considered an ill-posed problem because of this missing information. This results in artifacts, seen as the loss of three-dimensional (3D) resolution in the reconstructed images. The goal of this study was to achieve isotropic resolution with a statistical reconstruction method, sequential maximum a posteriori expectation maximization (sMAP-EM), using no prior morphological knowledge about …
Phylogenetic generic classification of parmelioid lichens (Parmeliaceae, Ascomycota) based on molecular, morphological and chemical evidence
2010
WOS: 000285566000008
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
2019
P.B. participated in the design, carried out the study, implemented the websites and search systems and wrote the manuscript. RELISH consortium annotated the articles. Y.Z. conceived the study, participated in the initial design, assisted in analyzing data and wrote the manuscript. All authors read, contributed to the discussion and approved the manuscript. Rayner Gonzálezlez-Prendes is member of the RELISH consortium. Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly deve…
Differences in tissue distribution of iron from various clinically used intravenous iron complexes in fetal avian heart and liver.
2015
Abstract Nanomedicines are more complex than most pharmacologically active substances or medicines and have been considered as non-biological complex drugs. For nanomedicines pivotal pharmacokinetic properties cannot be assessed by plasma concentration data from standard bioequivalence studies. Using intravenous iron complexes (IICs) as model we show that fetal avian tissues can be used to study time dependent tissue concentrations in heart and liver. Clear differences were found between equimolar doses of sucrose, gluconate or carboxymaltose coated iron particles. The range in tissue iron concentrations observed with these clinically widely used IICs provides an orientation as to what shou…