Search results for "generi"
showing 10 items of 125 documents
Estudio de la marca en la prescripción de genéricos en 6 centros de salud durante el año 2001
2003
ObjetivoEstudiar la marca prescrita de los medicamentos genéricos por los médicos de familia de 6 centros de salud de un área de atención primaria mediante el análisis de las recetas facturadas durante el año 2001.DiseñoEstudio descriptivo de la prescripción por receta médica.EmplazamientoÁrea de salud de atención primaria.Participantes/contextoSeis centros de salud, 3 de ubicación urbana y 3 de ubicación metropolitana.MétodoAnálisis de la prescripción farmacéutica a través del proceso de facturación de las recetas médicas con la ayuda del gestor para la prestación farmacéutica GAIA. El estudio se ha realizado con el 50% del total de los envases de medicamentos de alguna especialidad farmac…
L'eroicomico
2014
Il saggio analizza la genesi e la metamorfosi del poema eroicomico nella modernità, tra Seicento e primo Ottocento, con attenzione anche al suo influsso sul romanzo e su altri generi letterari. The essay examines the mock-heroic poem's genesis and metamorphosis between the seventeenth and the nineteenth century, also dealing with its influence upon modern novel and other literary genres.
All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome
2018
The spliceosome (SPL) is a majestic macromolecular machinery composed of five small nuclear RNAs and hundreds of proteins. SPL removes noncoding introns from precursor messenger RNAs (pre-mRNAs) and ligates coding exons, giving rise to functional mRNAs. Building on the first SPL structure solved at near–atomic-level resolution, here we elucidate the functional dynamics of the intron lariat spliceosome (ILS) complex through multi-microsecond-long molecular-dynamics simulations of ∼1,000,000 atoms models. The ILS essential dynamics unveils (i) the leading role of the Spp42 protein, which heads the gene maturation by tuning the motions of distinct SPL components, and (ii) the critical particip…
Theory-based digital intervention to promote weight loss and weight loss maintenance (Choosing Health)
2020
IntroductionDigital behavioural weight loss interventions have the potential to improve public health; however, these interventions are often not adequately tailored to the needs of the participants. This is the protocol for a trial that aims to determine the effectiveness and cost-effectiveness of the Choosing Health programme as a means to promote weight loss and weight loss maintenance among overweight/obese adults.Methods and analysisThe proposed study is a two-group randomised controlled trial with a nested interrupted time series (ITS) within-person design. Participants (n=285) will be randomly assigned to either the Choosing Health digital intervention or a control group. For interve…
Gli ascolti del poliziesco di Marcel Bénabou: dissertazione ermeneutica e contaminazione generica
2007
"Jette ce livre avant qu’il soit trop tard" di Marcel Bénabou, segretario definitivamente provvisorio e provvisoriamente definitivo dell’Oulipo, rappresenta insieme a "Pourquoi je n’ai écrit aucun de mes livres" e "Jacob, Menahem et Mimoun, une épopée familiale", l’esegesi dell’impossibilità della scrittura e della potenzialità della lettura così come è intesa dagli oulipiani: potenziale è un’opera che contiene inespresse ma en puissance ricchezze segrete che si prestano a un vero processo di esplorazione. Se in "Pourquoi je n’ai écrit aucun de mes livres" è l’atto di scrittura ad essere esplorato, e "Jacob" inscena «un romanzo che non è un romanzo ma la storia, incompiuta, di un romanzo ch…
Bioequivalence of oral products and the biopharmaceutics classification system: science, regulation, and public policy.
2011
The demonstration of bioequivalence (BE) is an essential requirement for ensuring that patients receive a product that performs as indicated by the label. The BE standard for a particular product is set by its innovator, and this standard must subsequently be matched by generic drug products. The Biopharmaceutics Classification System (BCS) sets a scientific basis for an improved BE standard for immediate-release solid oral dosage forms. In this paper, we discuss BE and the BCS, as well as the issues that are currently relevant to BE as a pharmaceutical product standard.
Modulational stability brought by cubic–quartic interactions of the nearest-neighbor in FK model subjected in a parametrized on-site potential
2022
Abstract This work extends to higher-order interactions the results of Ref. Nguetcho (2021), in which we discussed only on modulational instability in one-dimensional chain made of atoms, harmonically coupled to their nearest neighbors and subjected to an external on-site potential. Here we investigate the competition between cubic-quartic nonlinearities interactions of the nearest-neighbor and substrate’s deformability, and mainly discuss its impact on the modulational instability of the system. This makes it possible to adapt the theoretical model to a real physical system such as atomic chains or DNA lattices. The governing equation, derived from the modified Frenkel-Kontorova model, is …
Embedded students? Can libraries benefit from students having work placements in the library in planning library instruction?
2019
This article discusses how students can be more integrated in developing library instruction and what advantages that can provide for librarians planning their teaching. The students seem to have a different starting point as to how important the librarians’ knowledge of the subject at hand is and whether or not library instruction should be an integrated part of the course.
Defining relations of the noncommutative trace algebra of two 3×3 matrices
2006
The noncommutative (or mixed) trace algebra $T_{nd}$ is generated by $d$ generic $n\times n$ matrices and by the algebra $C_{nd}$ generated by all traces of products of generic matrices, $n,d\geq 2$. It is known that over a field of characteristic 0 this algebra is a finitely generated free module over a polynomial subalgebra $S$ of the center $C_{nd}$. For $n=3$ and $d=2$ we have found explicitly such a subalgebra $S$ and a set of free generators of the $S$-module $T_{32}$. We give also a set of defining relations of $T_{32}$ as an algebra and a Groebner basis of the corresponding ideal. The proofs are based on easy computer calculations with standard functions of Maple, the explicit prese…
Self-affine sets with fibered tangents
2016
We study tangent sets of strictly self-affine sets in the plane. If a set in this class satisfies the strong separation condition and projects to a line segment for sufficiently many directions, then for each generic point there exists a rotation $\mathcal O$ such that all tangent sets at that point are either of the form $\mathcal O((\mathbb R \times C) \cap B(0,1))$, where $C$ is a closed porous set, or of the form $\mathcal O((\ell \times \{ 0 \}) \cap B(0,1))$, where $\ell$ is an interval.