Search results for "geriatric"
showing 10 items of 1602 documents
Executive function and life-space mobility in old age
2018
Life-space assessment incorporates all movements in terms of the distance from home, the frequency of movement and the need of assistance for movement. Executive function (EF) is an important higher order cognitive ability that controls and guides people’s goal-directed actions. We examined the cross-sectional and longitudinal associations between EF and life-space mobility, and investigated if perceived walking difficulties, lower extremity performance, and transportation difficulties explain the association. Methods 157 community-dwelling persons aged 76–91 years participated in the study at the baseline, and 103 of them in 2-year follow-up study. Based on the distribution on the Trail Ma…
The combined effect of lower extremity function and cognitive performance on perceived walking ability among older people : a 2-year follow-up study
2018
Background We studied the combined effects of cognitive performance and lower extremity function on self-reported walking modifications and walking difficulty and on self-reported walking difficulty incidence over a 2-year follow-up. Methods A total of 848 community-dwelling older people aged 75-90 years participated at baseline, 816 at the 1-year follow-up, and 761 at the 2-year follow-up. Baseline lower extremity function was measured with the Short Physical Performance Battery (<10 vs. ≥10) and cognitive performance with the Mini-Mental State Examination (<24 vs. ≥24). Difficulty in walking 2 km was self-reported and categorized into no difficulties, no difficulties but walking modificat…
Do mobility, cognitive functioning, and depressive symptoms mediate the association between social activity and mortality risk among older men and wo…
2013
Social activity and health correlate in old age, but less is known about what explains this association. The aim of this study was to investigate whether mobility, cognitive functioning, and depressive symptoms mediate the association between social activity and mortality risk, or whether they alternatively should be considered as prerequisites for social activity in older Finnish men and women. In 1988, 406 men and 775 women aged 65–84 years took part in face-to-face interviews about their health, socioeconomic status, and social activities. Confirmatory factor analyses were used to form latent variables describing collective and productive social activity. Latent variable models were used…
Qué Podemos Aprender de los Sistemas Educativos de Chile, España y Finlandia en el Marco de la Declaración de Salamanca
2019
espanolEl presente articulo compara los sistemas de Educacion Especial de Chile, Espana y Finlandia, desde la perspectiva de la Declaracion de Salamanca para las Necesidades Educativas Especiales (NEE). Tanto el contexto general de sus sistemas educativos como su orientacion epistemologica respecto de la Educacion Especial, los marcos regulatorios de cada sistema, los procedimientos de deteccion y derivacion de ninos con NEE, y la estructura de los servicios de atencion a la diversidad, dialogan de manera particular con los compromisos adquiridos en 1994. Se muestran las principales diferencias entre los sistemas, destacando la gran variabilidad respecto de la definicion de NEE y sus estrat…
Serial Production, Serial Photography, and the Writing of History in Three Farmers on Their Way to a Dance.
2010
Three Farmers on their Way to a Dance, titre d’une photographie qu’August Sander prit en 1914, hante le roman éponyme de Richard Powers. Cette photographie faisait partie d’un projet plus vaste, intitulé « Hommes du vingtième siècle » par Sander qui entendait dresser un inventaire des habitants de sa province natale, le Westerwald. Sander composa ainsi un catalogue de plus de 600 photos d’Allemands de tous types, dont il fit plus tard paraître une partie sous le nom de Visage de notre temps. Dans le roman de Richard Powers, le motif de la série se déploie entre les pôles incarnés par Henry Ford et August Sander, dont les séries de voitures et de photographies deviennent la métaphore du mode…
Immunosenescence and Cytomegalovirus
2010
Since Looney at al. published their seminal paper a decade ago [1] it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated increasing prevalence of infection with the persistent β-herpesvirus HHV-5 (Cytomegalovirus). Ten years later, studies suggest that hallmark age-associated changes in peripheral blood T cell subset distribution may not occur at all in people who are not infected with this virus [[2]; Derhovanessian et al., in press]. Whether the observed changes are actually caused by CMV is an open question, but very similar, rapid changes observed in uninfected patients receiving CMV-in…
Immunosenescence and lymphomagenesis
2018
Abstract One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way. This review presents a brief overview of the interplay between aging, cancer and lymphoma, and the key topic of immunosenescence is addressed in the context of t…
Mung Bean nuclease mapping of RNAs 3' end
2009
Abstract A method is described that allows an accurate mapping of 3' ends of RNAs. In this method a labeled DNA probe, containing the presumed 3' end of the RNA under analysis is allowed to anneals to the RNA itself. Mung-bean nuclease is then used to digest single strands of both RNA and DNA. Electrophoretic fractionation of "protected" undigested, labeled DNA is than performed using a sequence reaction of a known DNA as length marker. This procedure was applied to the analysis of both a polyA RNA (Interleukin 10 mRNA) and non polyA RNAs (sea urchin 18S and 26S rRNAs). This method might be potentially relevant for the evaluation of the role of posttrascriptional control of IL-10 in the pat…
Curcumin, inflammation, ageing and age-related diseases
2010
Abstract A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini and Barbagallo is summarized. Ageing is manifested by the decreasing health status and increasing probability to acquire age-related disease such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others. They are likely caused by low grade inflammation driven by oxygen stress and manifested by the increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, encoded by genes activated by the transcription factor NF-κB. It is believed th…
Age and immunity
2006
Abstract Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.