Search results for "glia"
showing 10 items of 1274 documents
Andrea e gli argentieri Memingher in Sicilia
2018
Andrea Memingher è una tra le più enigmatiche figure di argentieri attivi a Palermo nella seconda metà del XVII secolo. Si può ritenere che la famiglia avesse origini nordiche e che, dopo un passaggio a Napoli, si stabilisse definitivamente a Palermo, inserendosi nella maestranza degli orafi e argentieri della città, probabilmente grazie ad un matrimonio con una figlia o una sorella o una vedova di un membro palermitano della maestranza. La presenza di Paolo Memingher nel capoluogo siciliano è attestata già nel 1660, due anni prima della data di inizio della sua attività, protrattasi fino al 1678. Il più importante esponente della famiglia fu Andrea, figlio di Paolo, il quale dovette la sua…
Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells
2019
Abstract Background Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation of more than 100 genes involved in the activation of neuronal death and inhibiting neurogenesis. Neuroprotective and cytoprotective activities of adaptogens rise the question about their possible impact on cytostatic effects of a chemotherapeutic combination of 5-fluorouracil, …
Biskup Würzburga Johann Philipp von Schönborn we francuskojęzycznej korespondencji Charlesa II i Jamesa II Stuartów z lat 1652-1673
2021
Podpisany w 1648 r. pokój westfalski nie kończył zmagań wojennych w Europie Zachodniej. Do 1658 r. trwała wojna francusko-hiszpańska, a po drugiej stronie kanału La Manche Anglia targana była najpierw wojną domową, a potem, pod władzą Oliwera Cromwella, uwikłała się w konflikt z Holandią (1652–1654), który stanowił jedynie preludium do kolejnych wojen między tymi państwami. Kluczową rolę w dobie zmagań z Niderlandami odgrywała Rzesza Niemiecka, gdzie jedną z czołowych postaci był biskup Würzburga (arcybiskup Moguncji) Johann Philipp von Schönborn. W planach politycznych uwzględniali go dyplomaci francuscy i habsburscy. O zainteresowaniu Anglików jego osobą świadczą listy Charlesa II i James…
Glutathione metabolism in primary astrocyte cultures: flow cytometric evidence of heterogeneous distribution of GSH content.
1993
The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. Astrocytes showed a narrow range of cellular size but a wide range of intracellular GSH. This heterogeneity was resolved into three distinct subpopulations which represent 20%, 35% and 45% of the total astrocyte number. The less abundant subpopulation had the lower GSH content, while the most abundant was the subpopulation with the higher content. Over 95% of astrocytes were in t…
Interazioni metropolitane
2020
Difficile presentare la ricerca di Giovanni Battista Cocco e Adriano Dessi escludendo quanto è accaduto negli ultimi mesi in seguito alla pandemia. Se si dovesse procedere nella riflessione senza tenere conto della diffusione del virus SARS-Cov-2 e della infezione Covid-19, ne scaturirebbe un quadro distorto e forse si apprezzerebbe solo in parte il lavoro dei due ricercatori che, osservando una specifica condizione metropolitana, ne palesano le peculiarità e, utilizzando il progetto di architettura come strumento di indagine, le potenzialità. Perché richiamare la pandemia se il volume è stato concluso poco prima che la sciagura si propagasse? Perché le conseguenze del virus hanno messo in …
Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial B…
2014
International audience; The objective of this study was to evaluate the biological activities of the major phytosterols present in argan oil (AO) and in cactus seed oil (CSO) in BV2 microglial cells. Accordingly, we first determined the sterol composition of AO and CSO, showing the presence of Schottenol and Spinasterol as major sterols in AO. While in CSO, in addition to these two sterols, we found mainly another sterol, the Sitosterol. The chemical synthesis of Schottenol and Spinasterol was performed. Our results showed that these two phytosterols, as well as sterol extracts from AO or CSO, are not toxic to microglial BV2 cells. However, treatments by these phytosterols impact the mitoch…
Verità instabili. L'eikos in Aristotele
2012
This paper deals with the Aristotelian concept of eikos, traditionally translated as “probability” or “likelihood", with the aim of showing the complexity and the theoretical worth of this notion. Eikos has already been an important concept in fields such as historiography and rhetoric and it plays a crucial role in Aristotelian thought, as well. According to Aristotle, eikos does not oppose itself to truth nor is it a second-level knowledge. Instead, it is a heuristic device that is extremely useful in conditions of uncertainty. Aristotle’s task was to offer a personal elaboration of a concept that already had a rich background and was suited to become a means for reflection on a crucial p…
Teste e testimonianze: i falsi Modigliani
2011
Analisi sociosemiotica della celebre beffa delle false teste di Modigliani.
The shaping of public economic discourse in postwar America: the 1947 meat shortage and Franco Modigliani's meat plan
2015
This paper discusses the American debate over price controls and economic stabilization after World War II, when the transition from a war economy to a peace economy was characterized by bottlenecks in the productive system and shortages of food and other basic consumer goods, directly affecting the living standard of the population, the public opinion, and political discourse. Specifically, we will focus on the economist Franco Modigliani and his proposal for a "Plan to meet the problem of rising meat and other food prices without bureaucratic controls." The plan prepared by Modigliani in October 1947 was based on a system of taxes and subsidies to foster a proper distribution of disposabl…
Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothal…
2015
Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3(+) or BrdU(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (GFAP(+)), and microglia (Iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with URB597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). Repeated URB597 treatment increased the plasma levels of the N-acylethanolamine…