Search results for "grant"
showing 10 items of 813 documents
Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population
2010
BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis.Methodology/principal findingsImmunoproteasomes and PA28-alphabeta regulator are present in MS affected brain area and accumulated in plaques. They are expressed in cell types supposed to be involved in MS development such as neurons, endothelial cells, oligodendroc…
Epidemiological, clinical, diagnostic and economic features of an immigrant population of chronic schistosomiasis sufferers with long-term residence …
2021
Background Schistosomiasis, one of the neglected tropical diseases (NTD) listed by the WHO, is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. Complications of long-term infestation include liver cirrhosis, bladder tumors and kidney failure. The objective of this study was to carry out a clinical and epidemiological characterization of a schistosomiasis-diagnosed immigrant population with long-term residencein the EU as well as to evaluate the diagnostic methods available to date. Methods and results A total of 61 individuals with Schistosoma infection who received medical attention between June 2002 and June 2016 at the North Metrop…
Health and self-perceived barriers to internet use among older migrants : a population-based study
2022
Background:In older adults, including those with a migrant background, ill health is associated with less internet use. However, it is not known what are the specific self-perceived barriers to internet use among older migrants with different health conditions. The aim of this study was to investigate the associations between different health conditions and self-perceived barriers to internet use among older migrants.Methods:We used the Care, Health and Ageing of Russian-speaking Minority in Finland (CHARM) study, which is a nationally representative survey of community-dwelling Russian-speaking adults aged ≥50 years living in Finland (N=1082, 57% men, mean age 63.2 years, standard deviatio…
Late-onset myasthenia gravis - CTLA4(low) genotype association and low-for-age thymic output of naïve T cells.
2014
Abstract Late-onset myasthenia gravis (LOMG) has become the largest MG subgroup, but the underlying pathogenetic mechanisms remain mysterious. Among the few etiological clues are the almost unique serologic parallels between LOMG and thymoma-associated MG (TAMG), notably autoantibodies against acetylcholine receptors, titin, ryanodine receptor, type I interferons or IL-12. This is why we checked LOMG patients for two further peculiar features of TAMG – its associations with the CTLA4 high/gain-of-function +49A/A genotype and with increased thymic export of naive T cells into the blood, possibly after defective negative selection in AIRE-deficient thymomas. We analyzed genomic DNA from 116 …
Epidemiological and clinical features in immigrant children with coeliac disease: an Italian multicentre study.
2004
Abstract Background. There are no available data concerning the incidence and the clinical pattern of coeliac disease in immigrant children coming to Italy from developing countries. Aims. To evaluate the epidemiological and clinical features of coeliac immigrant children coming to Italy. Patients and methods. Hospital records of 1917 children diagnosed in 22 Italian Centres from 1999 to 2001 as having coeliac disease were retrospectively reviewed, comparing immigrant patients versus Italian ones. Results. 36/1917 (1.9%) coeliac children were immigrant. This prevalence was similar to that of the immigrant children among the whole paediatric population living in Italy. Prevalence was influen…
Minding the Gaps : The Role of Finnish Civil Society Organizations in the Labour Market Integration of Migrants
2021
AbstractThe growing role of civil society organizations (CSOs) in welfare service provision is sometimes portrayed as a threat to welfare state universalism in Nordic societies. In Finland, CSOs co-produce integration services alongside comprehensive official integration programmes, compensating for gaps and shortcomings in those services. We identify three “gaps”, which are (1) limited availability of services in terms of time and target group, (2) lack of direct labour market contacts and (3) limited flexibility to serve individual needs. We assess how CSOs target these gaps with their service offerings through qualitative interviews with policy implementers, CSO workers and migrants. How…
Legal Issues Affecting Labour Market Integration of Migrants in Finland
2021
AbstractFinland has only relatively recently become a country of immigration, and as a result most immigration and integration policy legislation is also relatively recent. Since the 1990s, the number of migrants to Finland has increased steadily, motivating the adoption of various policy measures to regulate migration and support integration. From the perspective of migrant labour market integration, the two most important legislative acts are the Aliens Act (FINLEX 301/2004) and the Act on the Promotion of Immigrant Integration (FINLEX 1386/2010), which lay out basic labour market integration supports for migrants, and determine who can work in Finland and on which grounds. Finland’s comp…
Critical incidents which limit performance of Chilean University rowers who won a medal in the Pan American Games of Lima 2019
2020
Main objective of this study was to provide a basis for the comprehension of the main critical incidents (i.e. obstacles) that Chilean rowers who were medallists in the Pan American Games of Lima 2019 have to face within the academic, socioeconomic and sports processes. 19 athletes were selected through a non-probabilistic sampling. A content validated questionnaire and an in-deep interview were used. Higher levels of consistency were observed. Through the inferential analysis (ANOVA) it was possible to conclude that athletes are concerned with some academic and social crisis within their sporting career. This fact does not allow them to concentration and integral tranquillity to be focused…
Empowering Translation of New Ideas - A EIT Health ClinMed Summer School Overview
2019
Translational research training is crucial to convert academic research ideas into efficient real-life solutions. In this paper a summer school supported by EIT Health is presented. Its main goal is to integrate clinical knowledge in the development of new medical devices, from ideas to post-market approval, in the clinics. Students were immersed in clinical centres where they had close contacts and engaged discussions with clinicians and patients to identify and assimilate clinical unmet needs. From this immersive stage resulted innovative solutions that were further investigated with the support of plenary lectures and by interaction with experts of the medical field, from clinicians to M…
EUROMEDITERRANEAN BIOMEDICAL JOURNAL (EMBJ) TO SUPPORT THE INTERNATIONAL CALL FOR GRANTS FROM THE ITALIAN INSTITUTE OF HEALTH DEDICATED TO YOUNG RESE…
2022
EuroMediterranean Biomedical Journal (EMBJ) can be considered both a scientific journal and a learning tool for “researchers-in-training” coming from Euro-Mediterranean Countries and other areas of the globe. We announce the launch of an international call for grants from Istituto Superiore di Sanità (ISS, the Italian National Institute Health), reserved to young Italian and foreign researchers. We strongly encourage the junior researchers that have authored manuscripts published in EMBJ to consider the application to this extraordinary opportunity.