Search results for "grants"

showing 10 items of 352 documents

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

2010

BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis.Methodology/principal findingsImmunoproteasomes and PA28-alphabeta regulator are present in MS affected brain area and accumulated in plaques. They are expressed in cell types supposed to be involved in MS development such as neurons, endothelial cells, oligodendroc…

MaleT cells proteasomes multiple sclerosis parietal lobeMuscle ProteinsImmunoproteasomeEpitopeEpitopesGene FrequencyRisk FactorsCytotoxic T cellFunding: This work was financed in part by the grant Giovani Ricercatori 2007 from Italian Ministry of Health to MM DG and FMB by a grant from the European Commission Integrated Project PROTEOMAGE (FP6) to CF by the finalized projects of Fondazione Italiana Sclerosi Multipla (FISM) cod. 2003/R26 and BioPharmaNet to CF and 2002/R/40 and 2005/R/10 2008/R/11 (Genoa) to SD'A by the University of Bologna (FRO) to MPF by the Regione Piemonte (Ricerca Sanitaria Finalizzata Project and Ricerca Sanitaria Applicata-CIPE Project) to SD'A by Associazione Amici del Centro Dino Ferrari and IRCCS Ospedale Maggiore Policlinico Milano to DG and by the grants Sonderforschungsbereich (SFB-507 SFB-421) to PMK and US the grants TR43 and Neurocure to PMK. MM benefited from the A.V. Humboldt PostDoc fellowship. The funders had no role in study design data collection and analysis decision to publish or preparation of the manuscript.MultidisciplinaryMicrogliaQRBrainMiddle AgedImmunohistochemistryCysteine EndopeptidasesOligodendrogliamedicine.anatomical_structureItalyImmunoproteasome; multiple sclerosis; italian populationmultiple sclerosiImmunology/Antigen Processing and RecognitionMedicineFemaleMicrogliaNeuroscience/Neurobiology of Disease and RegenerationResearch ArticleProtein BindingAdultProteasome Endopeptidase ComplexMultiple SclerosisGenotypeScienceMolecular Sequence DataImmunology/AutoimmunityBiologySex FactorsMHC class IHLA-A2 AntigenmedicineHumansAmino Acid SequenceAlleleHLA-A AntigensMultiple sclerosisMacrophagesMyelin Basic Proteinmedicine.diseaseMyelin basic proteinImmunologybiology.proteinitalian populationCD8PLoS ONE
researchProduct

Epidemiological, clinical, diagnostic and economic features of an immigrant population of chronic schistosomiasis sufferers with long-term residence …

2021

Background Schistosomiasis, one of the neglected tropical diseases (NTD) listed by the WHO, is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. Complications of long-term infestation include liver cirrhosis, bladder tumors and kidney failure. The objective of this study was to carry out a clinical and epidemiological characterization of a schistosomiasis-diagnosed immigrant population with long-term residencein the EU as well as to evaluate the diagnostic methods available to date. Methods and results A total of 61 individuals with Schistosoma infection who received medical attention between June 2002 and June 2016 at the North Metrop…

MaleTime FactorsPhysiologymedicine.medical_treatmentlcsh:MedicineUrineLeukocyte CountSchistosomiasis haematobia0302 clinical medicineResidence CharacteristicsEpidemiologyMedicine and Health SciencesRenal TransplantationSchistosomiasisRenal Failure030212 general & internal medicinelcsh:ScienceSchistosoma haematobiumMultidisciplinarybiologyEukaryotaBody FluidsHelminth InfectionsNephrologyNeglected tropical diseasesSchistosomaFemaleHemodialysisAnatomymedicine.symptomResearch ArticleNeglected Tropical DiseasesAdultmedicine.medical_specialty030231 tropical medicineEmigrants and ImmigrantsSurgical and Invasive Medical ProceduresSchistosomiasisUrinary System Procedures03 medical and health sciencesDiagnostic MedicineHelminthsInternal medicineParasitic DiseasesmedicineAnimalsHumansDysuriaDemographySchistosomaTransplantationbusiness.industrylcsh:ROrganismsBiology and Life SciencesOrgan TransplantationTropical Diseasesbiology.organism_classificationmedicine.diseaseInvertebratesSchistosoma HaematobiumEosinophilsTransplantationSpainChronic Diseaselcsh:Qbusiness
researchProduct

Health and self-perceived barriers to internet use among older migrants : a population-based study

2022

Background:In older adults, including those with a migrant background, ill health is associated with less internet use. However, it is not known what are the specific self-perceived barriers to internet use among older migrants with different health conditions. The aim of this study was to investigate the associations between different health conditions and self-perceived barriers to internet use among older migrants.Methods:We used the Care, Health and Ageing of Russian-speaking Minority in Finland (CHARM) study, which is a nationally representative survey of community-dwelling Russian-speaking adults aged ≥50 years living in Finland (N=1082, 57% men, mean age 63.2 years, standard deviatio…

MalemasennusAgingmediankäyttötieto- ja viestintätekniikkadigital information technologymigrantscognitive functioningSurveys and QuestionnairesInternet useHumanskrooniset tauditMinority Groupsolder adultsAgedTransients and MigrantsInternetterveydentilaPublic Health Environmental and Occupational HealthMiddle Agedchronic conditionsesteetmaahanmuuttajatmaahanmuuttajatausta5142 Social policyInternet UsedepressionFemalebarriers to internet useikääntyneetpsyykkinen toimintakyky
researchProduct

Minding the Gaps : The Role of Finnish Civil Society Organizations in the Labour Market Integration of Migrants

2021

AbstractThe growing role of civil society organizations (CSOs) in welfare service provision is sometimes portrayed as a threat to welfare state universalism in Nordic societies. In Finland, CSOs co-produce integration services alongside comprehensive official integration programmes, compensating for gaps and shortcomings in those services. We identify three “gaps”, which are (1) limited availability of services in terms of time and target group, (2) lack of direct labour market contacts and (3) limited flexibility to serve individual needs. We assess how CSOs target these gaps with their service offerings through qualitative interviews with policy implementers, CSO workers and migrants. How…

Market integrationCivil societyEconomic growthrole of CSOsPublic AdministrationSociology and Political Sciencekotouttaminen (maahanmuuttajat)Strategy and Managementmedia_common.quotation_subjecttyömarkkinathyvinvointivaltio0502 economics and business050602 political science & public administration050207 economicsBusiness and International Management10. No inequalityUniversalismmedia_commonSocial policyService (business)rooli (tehtävä)05 social scienceshyvinvointipalvelutWelfare statewelfare state universalismmaahanmuuttajatkansalaisyhteiskunta0506 political scienceco-productionScale (social sciences)active labour market services for migrantskolmas sektori8. Economic growthBusinessWelfarejulkiset palvelutmigrant labour market integrationkansalaisjärjestöt
researchProduct

Legal Issues Affecting Labour Market Integration of Migrants in Finland

2021

AbstractFinland has only relatively recently become a country of immigration, and as a result most immigration and integration policy legislation is also relatively recent. Since the 1990s, the number of migrants to Finland has increased steadily, motivating the adoption of various policy measures to regulate migration and support integration. From the perspective of migrant labour market integration, the two most important legislative acts are the Aliens Act (FINLEX 301/2004) and the Act on the Promotion of Immigrant Integration (FINLEX 1386/2010), which lay out basic labour market integration supports for migrants, and determine who can work in Finland and on which grounds. Finland’s comp…

Market integrationLabour economicsmedia_common.quotation_subjectImmigrationMarket access050109 social psychologyLegislationmigrantstyömarkkinatCollective bargainingPolitical science0502 economics and business0501 psychology and cognitive sciences050207 economics10. No inequalityulkomaalaislakimedia_commonlainsäädäntökotoutuminen (maahanmuuttajat)työllistyminen05 social sciencesLegislatureWelfare statemaahanmuuttopolitiikkamaahanmuuttajatlabour market8. Economic growthResidencetyöoikeus
researchProduct

Critical incidents which limit performance of Chilean University rowers who won a medal in the Pan American Games of Lima 2019

2020

Main objective of this study was to provide a basis for the comprehension of the main critical incidents (i.e. obstacles) that Chilean rowers who were medallists in the Pan American Games of Lima 2019 have to face within the academic, socioeconomic and sports processes. 19 athletes were selected through a non-probabilistic sampling. A content validated questionnaire and an in-deep interview were used. Higher levels of consistency were observed. Through the inferential analysis (ANOVA) it was possible to conclude that athletes are concerned with some academic and social crisis within their sporting career. This fact does not allow them to concentration and integral tranquillity to be focused…

MedalHigher educationsports performanceApplied psychologyPublic policyPhysical Therapy Sports Therapy and RehabilitationContext (language use)elite sportsOlympismEducación Física y DeportivaHigher educationSocietySocioeconomic statusElite sportsbiologybusiness.industryAthletesSports performancebiology.organism_classificationolympismgrantssocietyGrantsTranquillitySocial transformationhigher educationSports medicinebusinessPsychologyRC1200-1245
researchProduct

I traffici illeciti nel Mediterraneo. Persone, stupefacenti, tabacco

2019

Attraverso la combinazione di ricerca criminologica e giuridico-normativa, e grazie anche alla collaborazione con esperti esterni (studiosi, magistrati, rappresentanti di istituzioni italiane e straniere), la ricerca da cui scaturisce il volume ha indagato le interazioni tra i diversi traffici illeciti e la criminalità organizzata nel bacino del Mediterraneo. In tale area, storicamente cruciale per la mobilità di persone e di beni, l’attenzione si è rivolta in particolare ai fenomeni del traffico e della tratta di persone, del traffico di stupefacenti e del contrabbando di sigarette. I contributi raccolti – unitamente al rapporto criminologico e ai cinque rapporti nazionali accessibili su w…

Mediterranean - Illicit Traffics - Smuggling of migrants - sostanze stupefacentiSettore IUS/16 - Diritto Processuale PenaleEste volumen es el resultado de la investigación bienal (2017-2019) "El nuevo Era del contrabando en el Mar Mediterráneo" financiado por el programa PYME - Impacto y gestionado por un equipo del Departamento de Derecho de la Universidad de Palermo compuesta por Vincenzo Militello (responsable de la científico) Alessandro Spena (coordinador) Annalisa Mangiaracina y Lycia syracuse. Mediante la combinación de investigaciones criminológicas y jurídico-normativas y gracias también a la colaboración con expertos externos (académicos magistrados representantes de instituciones italianas y extranjeras) la El proyecto investigó las interacciones entre los diferentes tipos de tráfico y de delito organizada en la cuenca del Mediterráneo. En esta área históricamente crucial para la movilidad de personas y bienes se ha prestado atención en particular a la los fenómenos de la trata y el contrabando de personas el tráfico de drogas y de contrabando de cigarrillos. Las contribuciones recogidas - junto con el informe criminológico y los cinco informes nacionales accesibles en www.unipa.it/nesmes.pmi y dedicado a los sistemas penales que se están investigando (Italia Alemania España Portugal Grecia) - pretenden proporcionar una visión profunda y variada del tema estudiado: el análisis y la reflexión socio-criminológica coexisten en él. legal (esto a su vez es tanto sustantivo como procesal) el estudio de las normas italianas y su colocación en una más amplio (europeo internacional pero también comparativo) el punto de vista del erudito y del magistrado. Surge la idea de que entre los tres tipos de tráfico considerado puede haber relaciones pragmáticas y estructurales a las que el los estados deberían dedicar más atención con vistas a un mayor contraste justo y eficaz como parte de un equilibrio entre la movilidad y la seguridad adecuado a la relevancia de la zona del Mediterráneo a nivel europeo y internacional.Settore IUS/17 - Diritto Penale
researchProduct

The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes.

2021

Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed i…

Mediterranean climatePoint of entryCOVID-19 VaccinesCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)RefugeeInfectious and parasitic diseasesRC109-216Genome ViralSettore MED/42 - Igiene Generale E ApplicataGenomeMediterranean seaPandemicHumansSocioeconomicsLetters to the EditorSicilyTransients and MigrantsSARS-CoV-2COVID-19General MedicineGeographyCOVID-19 COVID-19 Vaccines Genome Viral Humans Molecular Diagnostic Techniques SARS-CoV-2Sicily Transients and MigrantsMolecular Diagnostic TechniquesPublic aspects of medicineRA1-1270Annals of global health
researchProduct

La memòria recuperada: l’ús dels relats biogràfics en la segona i tercera generació dels emigrants valencians als Estats Units d’Amèrica a principi d…

2021

És habitual quan es fa ús del mètode biogràfic recollir els relats directament d'aquells que van viure els fets narrats, siguin estos tota una vida o alguns aspectes que l'investigador desitgi que siguin destacats. En la investigació duta a terme sobre la recuperació de la memòria dels emigrants valencians als Estats Units d'Amèrica durant les dues primeres dècades del segle XX això es presenta com un fet impossible: els que van viure en primera persona l'emigració ja han desaparegut. Es podria pensar que amb ells desapareixien també les seues històries. Però gràcies a un exhaustiu treball amb els seus descendents (filles i fills, nétes i néts, nebodes i nebots) i fent ús de tècniques que s…

Memòria recuperadaRecoverd memorylcsh:Ethnology. Social and cultural anthropologylcsh:GN301-674Emigrant's descendantsMaterials ChemistryBiographical methodDescendents emigrantsmètode biogràfic valencians als eeuu memòria recuperada descendents emigrantsValencia immigrants in USAMètode biogràficValencians als EEUUPerifèria. Revista d'investigació i formació en Antropologia
researchProduct

Il traffico di migranti. Diritti, tutele, criminalizzazione

2015

Il volume affronta il tema del traffico di migranti da un punto di vista interdisciplinare, raccogliendo contributi di studiosi di varia provenienza. L'argomento vi è trattato non solo nella prospettiva - penalistica - della criminalizzazione dei trafficanti, ma anche in quella delle tutele da accordare al migrante trafficato e dei diritti da riconoscergli

Migrant trafficking - Migrant rights - Migrants as victims - CriminalizationTraffico di migranti - Diritti - Tutele - CriminalizzazioneSettore IUS/17 - Diritto Penale
researchProduct