Search results for "harm"
showing 10 items of 13866 documents
A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.
2015
Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …
Esimies-alaissuhteen luottamus vuorovaikutuksessa rakentuvana ilmiönä
2015
Luottamus työpaikoilla on moniulotteinen tutkimuskohde, haastavuudessaan kiinnostava ja mukaansatempaava. Aihe on ajankohtainen, sillä luottamus korostuu muutoksessa ja sen viestinnässä. Luottamus työpaikoilla näkyy ilmapiirissä ja vaikuttaa työhyvinvointiin. Aiempi tutkimus on painottunut luottamuksen edellytyksiin ja seurauksiin, ei niinkään luottamuksen dynaamiseen luonteeseen. Tämän tutkimuksen tavoitteena on tutkia luottamuksen kehittymisen prosessia esimiehen ja alaisen välillä viestinnän ja vuorovaikutuksen näkökulmasta. Laadullinen tutkimusaineisto on kerätty haastattelemalla itäsuomalaisten palveluorganisaatioiden esimies-alaispareja erikseen ja yhdessä. Aineistosta paljastui, että…
Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma
2014
Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…
A novel improved matlab-based software for the electric and magnetic analysis and design of rotating electrical machines
2015
The aim of this paper is to present a software for the analysis and design of windings of rotating electrical machines, considering both the electric and the magnetic specifications on the machine. The considered machines are induction motors (IM) and PM synchronous motors (PMSM). The software accounts for the case of buried magnets (IPMSM), but with some limits, because the calculations require a much more detailed analysis regarding the magnetic circuit. However, this initial limitation of the software, that will be removed in a later version, does not constitute a major limitation as confirmed by the examples presented in this paper.
The charm-quark contribution to light-by-light scattering in the muon (−2) from lattice QCD
2022
We compute the hadronic light-by-light scattering contribution to the muon $g-2$ from the charm quark using lattice QCD. The calculation is performed on ensembles generated with dynamical $(u,d,s)$ quarks at the SU(3)$_{\rm f}$ symmetric point with degenerate pion and kaon masses of around 415 MeV. It includes the connected charm contribution, as well as the leading disconnected Wick contraction, involving the correlation between a charm and a light-quark loop. Cutoff effects turn out to be sizeable, which leads us to use lighter-than-physical charm masses, to employ a broad range of lattice spacings reaching down to 0.039 fm and to perform a combined charm-mass and continuum extrapolation.…
Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process
2019
A scalable low-shear membrane emulsification process was used to produce microencapsulated Escherichia coli-phages in a solid oral dosage form. Uniform pH-responsive composite microparticles (mean size ~100 µ
Brain Functional Effects of Psychopharmacological Treatment in Major Depression: A Focus on Neural Circuitry of Affective Processing
2015
In the last two decades, neuroimaging research has reached a much deeper understanding of the neurobiological underpinnings of major depression (MD) and has converged on functional alterations in limbic and prefrontal neural networks, which are mainly linked to altered emotional processing observed in MD patients. To date, a considerable number of studies have sought to investigate how these neural networks change with pharmacological antidepressant treatment. In the current review, we therefore discuss results from a) pharmacological functional magnetic resonance imaging (fMRI) studies investigating the effects of selective serotonin or noradrenalin reuptake inhibitors on neural activation…
Changes in Oxidative Stress Index and Lipid Peroxidation Product in the Brain of Rats with Lesion of Central Dopaminergic System after Propofol Admin…
2019
Propofol is a commonly used intravenous anesthetic agent with antioxidant properties. However, the effect of propofol on oxidative stress index (OSI) and lipid peroxidation in Parkinson’s disease is still unknown. The present study aimed to evaluate the effect of propofol on OSI and malondialdehyde (MDA) level in the selected brain regions of the rats with Parkinson’s disease (PD). 32 male Wistar rats were divided into four groups: I- control group, II- group with PD, III-control group with propofol, IV-PD group with propofol. 60mg/kg of propofol was given to the 8-weeks-old rats intraperitoneally, and the selected parts of the rats’ brains (frontal cortex, striatum, thalamus and hippocampu…
Dharmic Education - A Panacea for Social Evils in Emerging Economies
2014
Education is a tool of social change. The perceptions of people about the goals of education largely define the pattern of education structure. If the values of the society revolve around materialistic pursuits alone, it naturally promotes unbridled race for money. The products of that education system orient towards materialistic pursuits and the lofty ideals like Corporate Social Responsibility and business ethics that dominate the current managerial thought get lip sympathy in their hands. Realizing the need of ethical values in organizations, many universities of the West and certain prime institutions in India (ex- IIM, Bangalore) have introduced spiritual education in the course curri…
Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action
2019
The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an important phylum, whose members produce a huge number of compounds with diverse biological activities. In…