Search results for "harm"
showing 10 items of 13866 documents
Do the Mega and Titan Tests Yield Accurate Results? An Investigation into Two Experimental Intelligence Tests
2020
The Mega and Titan Tests were designed by Ronald K. Hoeflin to make fine distinctions in the intellectual stratosphere. The Mega Test purported to measure above-average adult IQ up to and including scores with a rarity of one in a million of the general population. The Titan Test was billed as being even more difficult than the Mega Test. In this article, these claims are subjected to scrutiny. Both tests are renormed using the normal curve of distribution. It is found that the Mega Test has a higher ceiling and a lower floor than the Titan Test. While the Mega Test may thus seem preferable as a psychometric instrument, it is somewhat marred by a number of easy items in its verbal section. …
Fondement philosophique de la néoténie linguistique : philosophie existentielle
2022
Héritée de la psychomécanique du langage de Gustave Guillaume, la néoténie linguistique de Samir Bajrić s’établit largement sur l’observation des espaces mentaux du locuteur, et poursuit une voie phénoménologique tout en révélant les rapports cognitifs qu’entretiennent le locuteur et la langue au cours de l’appropriation d’une langue ou d’une autre langue. S’inspirant de la néoténie biologique, la néoténie linguistique s’intéresse aux particularités humaines dues aux phénomènes néoténiques ; elle renvoie à une théorie du locuteur inachevé, mais il n’en demeure pas moins que nous ne saurions posséder intégralement une langue quelconque. À dire vrai, le changement de rapport cognitif entre le…
Projektowane zmiany w regulacji prawnej planowania przestrzennego w Polsce w świetle Europejskiego Zielonego Ładu
2022
Artykuł przedstawia dyskutowane obecnie na świecie zagadnienia związane z pojawieniem się nowych instrumentów mających na celu zapewnienie zrównoważonego rozwoju w kontekście rozważanej obecnie reformy systemu planowania i zagospodarowania przestrzennego w Polsce. W Europie przedmiotem szczególnej uwagi jest wizja nowego paradygmatu rozwoju przewidziana w ramach Europejskiego Zielonego Ładu. Obejmuje on nie tylko kwestie związane z problematyką zmian klimatu (czy szerzej ochrony środowiska) czy też np. tak istotną obecnie samowystarczalność energetyczną Europy, ale też przewiduje konkretne instrumenty służące wdrażaniu nowej wizji rozwoju oraz wskazuje na konieczność rozszerzenia udziału sp…
Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors
2023
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, and 41 were chosen for the synthesis based on the results of the in silico screening. Each of the synthesized compounds was tested for its in vitro antibacterial and antifungal activities using a variety of strains. All the compounds showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus pyogenes) as well as Gram-negativ…
Nanorings driven by a laser field
2013
We present the dynamics of an electron constrained over an 1D ring with radius of 0.142 nm driven by a laser field. The temporal evolution of the system is evaluated by a semi-analytical solution of the full quantum time dependent Schr¨odinger equation. In our calculation the gap energy between the ground and the first excited state of the nanoring is three times the photon energy laser (0.63 eV) and the laser intensity is 4·1014 W/cm2 . Our analysis is performed by considering different polarization states of the incident laser. Our attention is mainly focused on the study of the High Harmonic Generation (HHG), the energy and the angular momentum absorbed by the driven system. We observe 1…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Radial symmetry of p-harmonic minimizers
2017
"It is still not known if the radial cavitating minimizers obtained by Ball [J.M. Ball, Discontinuous equilibrium solutions and cavitation in nonlinear elasticity, Phil. Trans. R. Soc. Lond. A 306 (1982) 557--611] (and subsequently by many others) are global minimizers of any physically reasonable nonlinearly elastic energy". The quotation is from [J. Sivaloganathan and S. J. Spector, Necessary conditions for a minimum at a radial cavitating singularity in nonlinear elasticity, Ann. Inst. H. Poincare Anal. Non Lineaire 25 (2008), no. 1, 201--213] and seems to be still accurate. The model case of the $p$-harmonic energy is considered here. We prove that the planar radial minimizers are indee…
Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species
2022
Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…
IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.
2022
The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists com…