Search results for "harm"
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Kiusaamiskokemukset yhteisöön kiinnittymisen esteenä
2009
Artikkeli perustuu Puheviestinnän päivillä 25.9.2009 pidettyyn plenum-esitelmään Kiusaamiskokemukset yhteisöön kiinnittymisen esteenä.
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…
2016
A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…
Realization of time-resolved two-vacuum-ultraviolet-photon ionization
2009
International audience; Ultrafast dynamics of excited molecules is studied through time-resolved two-vacuum-ultraviolet (vuv)- photon ionization using a nonlinear volume autocorrelator unit. The two-vuv-photon process is induced by the intense fifth harmonic radiation of a femtosecond Ti:sapphire laser. In a proof-of-principle experiment, ultrafast dynamics of excited ethylene and oxygen molecules are investigated. Molecular decay times are deduced by comparing the experimental data with the results of a numerical model that accounts for the spatial and temporal characteristics of the harmonic field. The present experiments pave a convenient way for time domain investigations in the vuv-xuv s…
Synthesis and Structure Elucidation of Novel Spirooxindole Linked to Ferrocene and Triazole Systems via [3 + 2] Cycloaddition Reaction
2022
In the present work, a novel heterocyclic hybrid of a spirooxindole system was synthesized via the attachment of ferrocene and triazole motifs into an azomethine ylide by [3 + 2] cycloaddition reaction protocol. The X-ray structure of the heterocyclic hybrid (1″R,2″S,3R)-2″-(1-(3-chloro-4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carbonyl)-5-methyl-1″-(ferrocin-2-yl)-1″,2″,5″,6″,7″,7a″-hexahydrospiro[indoline-3,3″-pyrrolizin]-2-one revealed very well the expected structure, by using different analytical tools (FTIR and NMR spectroscopy). It crystallized in the triclinic-crystal system and the P-1-space group. The unit cell p…
Prawne aspekty prowadzenia apteki internetowej jako elementu rynku e-health
2018
Wykorzystanie nowoczesnych technologii informatycznych jest elementem rozwojowym rynku farmaceutycznego, a sprzedaż internetowa stanowi interesujący kanał dystrybucji produktów leczniczych. Termin „apteka internetowa” nie posiada swojej definicji legalnej w polskim prawie. Jest on jednak powszechnie stosowany dla określenia aptek ogólnodostępnych i punktów aptecznych, które za pomocą Internetu prowadzą działalność polegającą na sprzedaży wysyłkowej produktów leczniczych. Możliwość ta dotyczy wyłącznie leków dostępnych bez recepty. Kluczowe znaczenie dla prezentowanej problematyki ma pojęcie sprzedaży wysyłkowej. Prowadzenie działalności z zakresu sprzedaży produktów leczniczych, również na …
3-NPA induziert Ischämietoleranz der Rattenleber nach warmer Ischämie
2005
Until now little is known about the potential of 3-nitroproprionic acid (3-NPA) to reduce ischemia/ reperfusion injury (IRI) of the rat liver in vivo.
Darba vides riska faktoru un stresa ietekme uz Liepājas aptiekā strādājošo farmaceitu darba spējām
2019
Maģistra darbā ir pētīti darba vides riska faktori un stresa ietekme uz farmaceitiem, un to saistība ar nodarbināto darbspējām. Darbs sastāv no trīs daļām. Pirmajā daļā ir apkopota un analizēta literatūra par farmaceitu profesiju, kā arī ergonomiskiem un psihosociāliem riskiem. Otrajā daļā aprakstītas pētījumā lietotās metodes, bet trešajā daļā veikta iegūto rezultātu apkopošana un analīze. Literatūras analīze liecina, ka farmaceiti, kuri strādā aptiekā, pakļauti daudzveidīgiem darba vides risku faktoriem (fiziskiem, ergonomiskiem, psihosociāliem). Maģistra darbā, tika izmantotas Eiropā populāras darba vides risku un stresa līmeņu, novērtēšanas metodes. Iegūtie rezultāti uzrāda, ka farmacei…
Compared Binding Properties between Resveratrol and Other Polyphenols to Plasmatic Albumin: Consequences for the Health Protecting Effect of Dietary …
2014
International audience; Phytophenols are considered to have beneficial effects towards human physiology. They are food microcomponents with potent chemopreventive properties towards the most three frequent contemporary human diseases, e.g., cardiovascular alterations, cancer and neurodegenerative pathologies. Related to this, the plasmatic form and plasmatic level of plant polyphenols in the body circulation are crucial for their efficiency. Thus, determinations of the binding process of resveratrol and of common flavonoids produced by major edible plants, berries and fruits to plasma proteins are essential. The interactions between resveratrol and albumin, a major plasma protein, were comp…
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…
2009
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…
The Radó–Kneser–Choquet theorem for $p$-harmonic mappings between Riemannian surfaces
2020
In the planar setting the Rad\'o-Kneser-Choquet theorem states that a harmonic map from the unit disk onto a Jordan domain bounded by a convex curve is a diffeomorphism provided that the boundary mapping is a homeomorphism. We prove the injectivity criterion of Rad\'o-Kneser-Choquet for $p$-harmonic mappings between Riemannian surfaces. In our proof of the injecticity criterion we approximate the $p$-harmonic map with auxiliary mappings that solve uniformly elliptic systems. We prove that each auxiliary mapping has a positive Jacobian by a homotopy argument. We keep the maps injective all the way through the homotopy with the help of the minimum principle for a certain subharmonic expressio…