Search results for "harm"
showing 10 items of 13866 documents
Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review
2021
With the development of electrical stimulation technology, traditional transcranial alternating current stimulation (tACS) technology has been found to have the drawback of not targeting a specific area accurately. Studies have shown that optimizing the number and position of electrodes during electrical stimulation has a very good effect on enhancing brain stimulation accuracy. At present, an increasing number of laboratories have begun to optimize tACS. However, there has been no study summarizing the optimization methods of tACS. Determining whether different optimization methods are effective and the optimization approach could provide information that could guide future tACS research. …
Le médicament homéopathique dans l'histoire du médicament, Co construction, confrontation, coopération. Histoire, Transmission, Représentation
2007
The dynamics of this thesis resides in the search for the breach between the historical positioning (in relation to scientific fact itself) of homeopathic medication in the history of medical sciences, and the representation made of it in the past and present. By distinguishing what may be at stake, we are led to identify the positioning and impact of the mode of transmitting scientific fact as lacking a historical link to the history of medical sciences, notably medication. Our research hypothesis thus postulates that the transmission mode is at the source of discrepancies in representation. The links between context breakthroughs, such as the role of influences, are just parameters that, …
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
Tunneilmaisu virtuaalitiimien tapaamisissa
2016
Tunneilmaisu on keskeinen osa työelämän ja sen tiimien vuorovaikutusta. Tunneilmaisulla tarkoitetaan sekä verbaalisia että nonverbaalisia ilmauksia, jotka viestivät ilmaisijan tunteista. Aiemmassa tutkimuksessa tunneilmaisua ei ole juurikaan havainnoitu itsessään merkittävänä osana tiimin vuorovaikutusta. Lisäksi tunneilmaisua on tutkittu lähinnä kvantitatiivisesti, opiskelijaryhmien ja tekstialustojen näkökulmasta. Artikkelissa tarkastellaan tiimiin ja tiimityöhön kohdistuvaa tunneilmaisua virtuaalitiimeissä. Analysoimme paitsi tunneilmausten sisältöä ja yleisyyttä myös niiden kytkeytymistä tiimin muuhun vuorovaikutukseen. Artikkeli pohjautuu luonnollisesta virtuaalitiimiaineistosta laadul…
Näkökulmia koulun ja työpaikan kiusaamissuhteisiin
2006
Tässä artikkelissa tarkastellaan koulu- ja työpaikkakiusaamista vuorovaikutussuhteiden näkökulmasta. Kiusaaminen määritellään pitkäkestoiseksi prosessiksi, jossa yksilö kokee joutuvansa toisen yksilön, ryhmän tai yhteisön järjestelmällisen ja toistuvan loukkaavan ja/tai aggressiivisen käyttäytymisen kohteeksi. Koulu- ja työpaikkakiusaamisen ilmiöissä on havaittu paljon yhteneväisyyksiä, mutta myös eroja. Kiusaamisilmiötä on tähän mennessä tutkittu pääasiallisesti yksilön, ryhmän ja yhteisön näkökulmista. Tuore näkökulma sen sijaan on kiusaamisen tarkastelu vuorovaikutussuhteiden tasolla. Artikkelissa käsitellään kiusaamisilmiötä nimenomaan vuorovaikutussuhteen – kiusaamissuhteen – näkökulma…
Compensation of Nonlinearity of Voltage and Current Instrument Transformers
2019
This paper aims at characterizing and improving the metrological performances of current and voltage instrument transformers (CTs and VTs) in harmonic measurements in the power system. A theoretical analysis is carried out to demonstrate that, due to the iron core nonlinearity, CT and VT output signal is distorted even when the input signal is a pure sine wave. Starting from this analysis, a new method for CT and VT characterization and compensation is proposed. In a first step, they are characterized in sinusoidal conditions and the harmonic phasors of the distorted output are measured; in the second step, these phasors are used to compensate the harmonic phasors measured in normal operati…
The Role of Existential Concerns in the Individual’s Decisions regarding COVID-19 Vaccine Uptake: A Survey among Non-Vaccinated Italian Adults during…
2022
Recent studies have suggested that health constructs embraced by the Terror Management Theory (TMT) and the Basic Psychological Needs Theory (BPNT) may drive individuals’ COVID-19 health-related decisions. This study examines the relationships between existential concerns (ECs; within the TMT), basic psychological needs (BPNs; within the BPNT) and COVID-19 vaccine hesitancy (VH), as well as the mediating role of negative attitudes toward COVID-19 vaccines. A cross-sectional survey was carried out from April to May 2021 on a sample of two hundred and eighty-seven adults (Mage = 36.04 ± 12.07; 59.9% females). Participants provided information regarding existential concerns, basic psychologica…
Aportación de la monitorización farmacocinética de vancomicina a la calidad farmacoterapéutica y seguridad del paciente neonato prematuro
2014
Vancomicina es un antibiótico utilizado con gran frecuencia en pacientes neonatos prematuros ingresados en las Unidades de Cuidados Intensivos Neonatales. La elevada variabilidad en los parámetros farmacocinéticos en este grupo de población representa la mayor barrera en el desarrollo y en la optimización de regímenes de dosificación. Esta situación favorece el desarrollo de diversas recomendaciones basadas en modelos farmacocinéticos poblacionales y nomogramas de dosificación, que consideran, para el cálculo de la dosis, variables como la edad postconcepcional, postnatal, creatinina sérica o el peso de los pacientes. Sin embargo, la experiencia clínica ha puesto de relieve que las concentr…