Search results for "harm"
showing 10 items of 13866 documents
Chemical Composition of Herbal Macerates and Corresponding Commercial Essential Oils and Their Effect on Bacteria Escherichia coli
2017
This study addresses the chemical composition of some commercial essential oils (clove, juniper, oregano, and marjoram oils), as well as appropriate herbal extracts obtained in the process of cold maceration and their biological activity against selected Escherichia coli strains: E. coli ATTC 25922, E. coli ATTC 10536, and E. coli 127 isolated from poultry waste. On the basis of the gas chromatography-mass spectrometry (GCMS) analysis, it was found that the commercial essential oils revealed considerable differences in terms of the composition and diversity of terpenes, terpenoids and sesquiterpenes as compared with the extracts obtained from plant material. The commercial clove, oregano, a…
The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol
2021
N-acetylcysteine (NAC) is a prodrug that is marketed as a mucolytic agent and used for the treatment of acetaminophen overdose. Over the last few decades, evidence has been gathered that suggests the potential use of NAC as a new pharmacotherapy for alcohol use disorder (AUD), although its mechanism of action is already being debated. In this paper, we set out to assess both the potential involvement of the glutamate metabotropic receptors (mGluR) in the possible dual effect of NAC administered at two different doses and NAC’s effect on ethanol-induced activation. To this aim, 30 or 120 mg/kg of NAC was intraperitoneally administered to rats with the presence or absence of the negative allo…
Comparison Study of Two Differently Clicked 18F-Folates—Lipophilicity Plays a Key Role
2018
Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable 18F-folates for clinical PET imaging. Herein, we report the synthesis and evaluation of two novel 18F-folates employing strain-promoted and copper-catalyzed click chemistry. Furthermore, the influence of both click-methods on lipophilicity and pharmacokinetics of the 18F-folates was investigated. 18F-Ala-folate and 18F-DBCO-folate were both stable in human serum albumin. In vitro studies proved their high affinity to the folate receptor (FR). The lipophilic character of …
Maladie de Parkinson, nutrition et micronutrition
2020
EnglishAlthough diet is not a major contributor to the onset of Parkinson’s disease, it seems to play an important role in its progression. The Mediterranean model is particularly suitable for Parkinson’s patients. On the other hand, par-ticular attention must be paid to protein intake, especially in the advanced stages. Certain supplements can be proposed, such as omega 3 fatty acids, vitamin D and some francaisSi l’alimentation est peu impliquee dans le declenchement de la maladie de Parkinson, elle semble avoir un role important dans son evolution. Le modele mediterraneen convient particulierement aux patients parkinsoniens. En revanche, une attention particuliere doit etre portee aux ap…
Adrenoceptors—New roles for old players
2019
LINKED ARTICLES This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
Un accompagnement sur mesure
2018
Resume Le diagnostic, l’initiation de traitement, les switches therapeutiques et les periodes a risques sont des moments cles dans l’accompagnement du patient atteint de sclerose en plaques. Tout au long de sa prise en charge, le malade exprime de nombreuses attentes vis-a-vis du pharmacien, ce qui implique une collaboration renforcee entre les professionnels de sante et, pour l’officinal, le developpement de nouveaux champs d’intervention.
Délivrance d’une ordonnance dans le cadre d’un trouble anxieux
2020
Afin d’etre correctement dispensee par l’equipe officinale, puis prise en charge par la caisse d’Assurance maladie, une prescription medicale de medicaments doit contenir un certain nombre d’elements obligatoires. Les erreurs reglementaires qui ont ete introduites sur l’ordonnance d’une patiente presentant des troubles anxieux doivent etre identifiees.
Conseil en aromathérapie et sommeil
2019
Resume Que la plainte concerne un endormissement difficile, des eveils nocturnes ou un reveil matinal precoce, l’aromatherapie peut constituer une aide interessante pour le patient insomniaque qui envisage une approche non medicamenteuse.
Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin—Two Main Metabolites of Curcuma longa—in C…
2017
ABSTRACT Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions. Here we investigated chemoprofiles of three Curcuma species and observed a great variety of phytochemicals with curcumin being among the few present in all three species. On the other hand ascorbic acid (AA) was a compound that was solely found in Curcuma longa. In the present study we explored the cytotoxic effect of a curcumin/AA combination toward human cancer cell lines. The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model. The drug combination showed additive cytotoxicity towards CCRF-CEM and CEM/ADR…
Target Identification of Active Constituents of Shen Qi Wan to Treat Kidney Yang Deficiency Using Computational Target Fishing and Network Pharmacolo…
2019
Background: Kidney yang deficiency syndrome (KYDS) is one of the most common syndromes treated with traditional Chinese medicine (TCM) among elderly patients. Shen Qi Wan (SQW) has been effectively used in treating various diseases associated with KYDS for hundreds of years. However, due to the complex composition of SQW, the mechanism of action remains unknown. Purpose: To identify the mechanism of the SQW in the treatment of KYDS and determine the molecular targets of SQW. Methods: The potential targets of active ingredients in SQW were predicted using PharmMapper. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out using the …