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Research and Science Today 1(11)/2016
2016
In this issue are included scientific articles which debate problems from social science fields: a brief summary of the hospital for contagious diseases in craiova, multi-level governance, state - church relationship and religious context, nuclear safety, the new caliphate, role of stress management, offences by which the legal regime, incrimination in the migrant trafficking, elements of spiritual autobiography, l2 spanish acquisition, quality through education, improving the communication of teaching, killer cell immunoglobulin-like receptors genes, pulmonary nodules, non-muscle invasive bladder cancer, the influence of steatosis, differential diagnosis between colonic crohn`s disease and…
Bezpieczeństwo młodzieży gimnazjalnej województwa opolskiego w cyberprzestrzeni
2017
Przedmiotem niniejszego artykułu jest bezpieczeństwo młodzieży gimnazjalnej w Internecie, w województwie opolskim. W kwietniu 2016 r. przeprowadzono anonimowe badanie nad poczuciem bezpieczeństwa w sieci uczniów wybranych szkół gimnazjalnych, w klasach od I do III. Na ankiety odpowiedziało 799 uczniów, w tym 393 kobiet i 406 mężczyzn. Z badań wynika, że wszyscy badani korzystają z Internetu, większość z nich codziennie. Poczucie bezpieczeństwa wśród badanych jest wysokie. Większość uczniów korzysta z Internetu zarówno dla rozrywki i aby przygotować się do zajęć w szkole. Warto zauważyć, że młodzież w wieku gimnazjalnym bardzo dużo czasu poświęca na rozrywkę w Internecie. Większość ankietowa…
Docosahexaenoic Acid Induces Increases in [Ca2+]ivia Inositol 1,4,5-Triphosphate Production and Activates Protein Kinase Cγ and -δ via Phosphatidylse…
2007
We investigated, in monocytic leukemia U937 cells, the effects of docosahexaenoic acid (DHA; 22:6 n-3) on calcium signaling and determined the implication of phospholipase C (PLC) and protein kinase C (PKC) in this pathway. DHA induced dose-dependent increases in [Ca2+]i, which were contributed by intracellular pool, via the production of inositol-1,4,5-triphosphate (IP3) and store-operated Ca2+ (SOC) influx, via opening of Ca2+ release-activated Ca2+ (CRAC) channels. Chemical inhibition of PLC, PKCgamma, and PKCdelta, but not of PKCbeta I/II, PKCalpha, or PKCbetaI, significantly diminished DHA-induced increases in [Ca2+]i. In vitro PKC assays revealed that DHA induced a approximately 2-fol…
Energy metabolism and intracellular pH in boar spermatozoa
2003
The effect of energy metabolism on intracellular pH was studied in boar spermatozoa using nuclear magnetic resonance (NMR) spectroscopy and confocal microscopy with the pH-sensitive dye seminaphthorhodafluor (SNARF-1). Freshly ejaculated spermatozoa had a high adenylate energy charge (AEC=0.8), which decreased to 0.6 under aerobic conditions and to 0.2 under anaerobic conditions. Correspondingly, no ATP resonances but high AMP resonance were visible in (31)P-NMR-spectra of the spermatozoa. When an artificial oxygen buffer (Fluosol) and a purpose-built air supply system were used during (31)P-NMR data acquisition, ATP resonances reappeared whereas the AMP resonance disappeared. Boar spermato…
Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture
2004
The signal transduction pathways involved in NMDA receptor modulation by other receptors remain unclear. cAMP could be involved in this modulation. The aim of this work was to analyse the contribution of cAMP to NMDA receptor modulation in cerebellar neurones in culture. Forskolin increases cAMP and results in increased intracellular calcium and cGMP that are prevented by blocking NMDA receptors. Similar effects were induced by two cAMP analogues, indicating that cAMP leads to NMDA receptor activation. It has been reported that phosphorylation of Ser897 of the NR1 subunit of NMDA receptors by cAMP-dependent protein kinase (PKA) activates the receptors. Forskolin increases Ser897 phosphoryla…
Highly selective recovery of Ni(II) in neutral and acidic media using a novel Ni(II)-ion imprinted polymer
2022
In this work, an original ion-imprinted polymer (IIP) was synthetized for the highly selective removal of Ni(II) ions in neutral and acidic media. First a novel functional monomer (AMP-MMA) was synthetized through the amidation of 2-(aminomethyl)pyridine (AMP) with methacryloylchloride. Following Ni(II)/AMP-MMA complex formation study, the Ni(II)-IIP was produced via inverse suspension polymerization (DMSO in mineral oil) and characterized with solid state 13C CPMAS NMR, FT-IR, SEM and nitrogen adsorption/desorption experiments. The Ni(II)-IIP was then used in solid-phase extraction of Ni(II) exploring a wide range of pH (from neutral to strongly acidic solution), several initial concentrat…
Phosphogenesis in the Bonarelli Level from northwestern Sicily, Italy: petrographic evidence of microbial mediation and related REE behaviour
2010
Phosphogenesis at the base of the Bonarelli Level from the Calabianca stratigraphic section (northwestern Sicily) was investigated using X-ray diffraction, scanning electron microscopy, X-ray fluorescence, and stable-isotope mass spectrometry. The anoxic event onset is marked by high P(2)O(5tot) concentrations related to the presence of authigenic carbonate-fluorapatite. This mineral is poorly crystallized and occurs in three different forms: (i) fish debris locally showing evidence of re-crystallization, (ii) phosphatically cemented layers, and (iii) dense aggregates of microcrystals. Petrographic features are indicative of a microbial genesis for the carbonate-fluorapatite. Conversely, th…
Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency
2014
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and repair. Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis. We show here that the levels of the Sml1 protein, a yeast RNR large-subunit inhibitor, specifically decrease in response to both nutritional and genetic Fe deficiencies in a Dun1-dependent but Mec1/Rad53- and Aft1-independent manner. The decline of Sml1 protein levels upon Fe starvation depends on Dun1 forkhead-associated and kinase domains, the 26S proteasome, and the vacuolar pr…
A physiologically active interpenetrating collagen network that supports growth and migration of epidermal keratinocytes: zinc-polyP nanoparticles in…
2020
The distinguished property of the physiological polymer, inorganic polyphosphate (polyP), is to act as a bio-intelligent material which releases stimulus-dependent metabolic energy to accelerate wound healing. This characteristic is based on the bio-imitating feature of polyP to be converted, upon exposure to peptide-containing body fluids, from stable amorphous nanoparticles to a physiologically active and energy-delivering coacervate phase. This property of polyP has been utilized to fabricate a wound mat consisting of compressed collagen supplemented with amorphous polyP particles, formed from the inorganic polyanion with an over-stoichiometric ratio of zinc ions. The proliferation and t…
Resealing of large transmembrane pores produced by streptolysin O in nucleated cells is accompanied by NF‐κB activation and downstream events
2001
Streptolysin O (SLO), archetype of a cholesterol-binding bacterial cytolysin, forms large pores in the plasma membrane of mammalian cells. We have recently reported that when a limited number of pores are generated in a cell, they can be sealed in a Ca++-dependent process. Here, we show that resealing is followed by the release of IL-6 and IL-8 from keratinocytes and from endothelial cells, both relevant targets for SLO attack. Production of cytokines by these cells was preceded by activation of transcription factor nuclear factor kappaB, which thus emerges as a common denominator of stress responses to various pore-forming agents, including alpha-toxin of Staphylococcus aureus and compleme…