Search results for "hazard"
showing 10 items of 1517 documents
Association of statin use and clinical outcomes in heart failure patients : a systematic review and meta-analysis
2019
Abstract Background The role of statins in patients with heart failure (HF) of different levels of left ventricular ejection fraction (LVEF) remains unclear especially in the light of the absence of prospective data from randomized controlled trials (RCTs) in non-ischemic HF, and taking into account potential statins’ prosarcopenic effects. We assessed the association of statin use with clinical outcomes in patients with HF. Methods We searched PubMed, EMBASE, Scopus, Google Scholar and Cochrane Central until August 2018 for RCTs and prospective cohorts comparing clinical outcomes with statin vs non-statin use in patients with HF at different LVEF levels. We followed the guidelines of the 2…
Prognostic indicators in pediatric clinically isolated syndrome
2017
Objective To assess prognostic factors for a second clinical attack and a first disability-worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods A cohort of 770 pCIS patients was followed up for at least 10 years. Cox proportional hazard models and Recursive Partitioning and Amalgamation (RECPAM) tree-regression were used to analyze data. Results In pCIS, female sex and a multifocal onset were risk factors for a second clinical attack (hazard ratio [HR], 95% confidence interval [CI] = 1.28, 1.06–1.55; 1.42, 1.10–1.84, respectively), whereas disease-modifying drug (DMD) exposure reduced this risk (HR, 95% CI = 0.75, 0.60–0.95…
Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards
2015
International audience; Food contact materials (FCM) represent a major economic issue and also an important field of innovation for packaging industries. Food packaging production must currently meet manufacturing good practices, safety for human health and thus be in compliance with the article 3 of the European Regulation 1935/2004: “Material and articles in contact with food do not transfer substances in amounts which could endanger human health…”.
Using a hazard-independent approach to understand road-network robustness to multiple disruption scenarios
2021
Abstract A range of predictable and unpredictable events can cause road perturbations, disrupting traffic flows and more generally the functioning of society. To manage this threat, stakeholders need to understand the potential impact of a multitude of predictable and unpredictable events. The present paper adopts a hazard-independent approach to assess the robustness (ability to maintain functionality despite disturbances) of the Sioux Falls network to all possible disruptions. This approach allows understanding the impact of a wide range of disruptive events, including random, localised, and targeted link failures. The paper also investigates the predictability of the link combinations wh…
Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patien…
2012
Objective To investigate the relationship between response to antiretroviral therapy (ART), alcohol use and occurrence of a major coronary or other arterial disease event (CADE) in HIV-infected individuals. Design A cohort study. A Cox model was used to identify the correlates of a first occurrence of a major CADE. Setting The French ANRS CO8 APROCO-COPILOTE cohort was set up in 1997 to study clinical progression and patient-reported outcomes (PRO) after initiating a protease inhibitor-containing ART. Clinical data were retrieved from medical records. Self-administered questionnaires collected data on PRO and behaviours, including alcohol use. Participants Metabolic data were only available…
Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes
2011
Abstract. Luotola K, Pietila A, Zeller T, Moilanen L, Kahonen M, Nieminen MS, Kesaniemi YA, Blankenberg S, Jula A, Perola M, Salomaa V (Helsinki University Hospital, Helsinki; National Institute for Health and Welfare, Helsinki, Finland; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany; University Hospital of Kuopio, Kuopio; Tampere University Hospital and Medical School, University of Tampere, Tampere; University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu; National Institute for Health and Welfare, Turku; and Institute for Molecular Medicine Finland, Helsinki, Finland). Associations between interleukin-1 (IL-1) gene variations …
Time-Varying mHAP-III Is the Most Accurate Predictor of Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
2021
<b><i>Introduction:</i></b> The prognosis of patients undergoing transarterial chemoembolization (TACE) is extremely variable, and a confounding factor is that TACE is often repeated several times. We retrospectively evaluated the accuracy of different prognostic scores and staging systems in estimating overall survival (OS) in patients with hepatocellular carcinoma (HCC). <b><i>Methods:</i></b> An analysis considering prognostic models as time-varying variables was performed, calculating OS from the time of TACE to the time of the subsequent treatment. Total follow-up time for each patient was therefore split into several observation times ac…
Exposure assessment of Spanish lactating mothers to acrylamide via human biomonitoring.
2021
Abstract Acrylamide (AA) is an organic compound classified as “Probably carcinogenic to humans” (Group 2 A) that can be found principally in processed carbohydrate-rich foods and tobacco smoke. In humans, after exposure, AA is rapidly metabolized and excreted in urine, predominantly as N-acetyl-S-(2-carbamoylethyl)-l-cysteine (AAMA), N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-l-cysteine (GAMA3) and N-Acetyl-3-[(3-amino-3-oxopropyl)sulfinyl]-L-alanine (AAMA-Sul), which can be used as short-term biomarkers of exposure to AA. In this study, the presence of AA metabolites in urine samples of lactating mothers living in Spain (n = 114) was analyzed by “dilute and shoot” and liquid chromatography co…
Geodetic and geological evidence of active tectonics in south-western Sicily (Italy)
2014
Abstract Integrated geological, geodetic and marine geophysical data provide evidence of active deformation in south-western Sicily, in an area spatially coincident with the macroseismic zone of the destructive 1968 Belice earthquake sequence. Even though the sequence represents the strongest seismic event recorded in Western Sicily in historical times, focal solutions provided by different authors are inconclusive on possible faulting mechanism, which ranges from thrusting to transpression, and the seismogenic source is still undefined. Interferometric (DInSAR) observations reveal a differential ground motion on a SW–NE alignment between Campobello di Mazara and Castelvetrano (CCA), locate…
The Separating Role of Collateral Requirements in Credit Markets with Asymmetric Information
2001
In this paper we test Bester's (1985, 1987) prediction about the separating role of contracts that involve both interest rates and collateral requirements in credit markets. To test this prediction we use data from natural credit markets and controlled experiments. Using a sample of credits to small and medium size firms in Valencia, Spain, we relate two different types of contracts with the ex post risk type of the borrower and other relevant variables. We then design two incentive compatible contracts and analyze decisions under two different experimental treatments, one with moral hazard. Our empirical results confirm that borrowers of ex post lower risk choose contracts with higher coll…