Search results for "healing"
showing 10 items of 642 documents
Loneliness and its relation to mental health in the general population: Validation and norm values of a brief measure
2021
Abstract Background Loneliness has been increasingly recognized as an important determinant of mental health. The purposes of this study were to (1) determine the degree of loneliness of women and men across different age groups, (2) explore its association with distress, (3) psychometrically evaluate the Three-Item Loneliness Scale, (4) provide norm values. Methods The Three-Item Loneliness Scale was applied in a representative survey of the German population (N=2527; 14–95 years). Standardized scales were used measuring distress (depression and anxiety symptoms, perceived stress, hopelessness, suicidal ideation, fatigue, life satisfaction). Factor structure and measurement invariance acro…
Fibrillar polymeric patches suitable for wound healing
2018
Multilayered scaffolds can be designed to improve soft material applicability for regenerative medicine purposes. Excellent results can be obtained by combining the main characteristics of the biopolymers and giving a specific function to each layer. A microfluidic-assisted electrospinning process is an elegant arrangement between two fiber fabrication techniques that defines finely every portion of an electrospun scaffold. Unlike classic electrospinning technique, multiple flows can be carefully monitored and separated in real time using microfluidic sensors. This method allows users to establish anisotropic properties to scaffolds, in other words it is possible to modulate gradients by ch…
Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.
1991
Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…
Estudio funcional del receptor de glucocorticoides en desarrollo y reparación epitelial
2013
Tesis doctoral; 181 páginas, ilustraciones. Este estudio se ha desarrollado en el Instituto de Biomedicina de Valencia (IBV-CSIC), bajo la dirección de la Dra. Paloma Pérez Sánchez
Aby odzyskać zdrowie, złóż ofiarę w świątyni. Mechanika uzdrowień i punktów życia w grach fabularnych
2019
Pen and paper RPGs are on the rise once morę, after two decades of continuus decline, and as morę and morę important they become in the gaming media as a whole, it is important to look at their approach towards narrative and gamę design. One of the most difficult things to do in tabletop RPG design is simulating the process of getting wounded and then healed. As heroes of this games tend to participate in rather dangerous adventures, wounds are in- evitable and so is attending to them. Different games have different Solutions for presenting them, and as I presented in the paper, those approaches can be seen by their devotion towards realism or clean mathematics of gamę mechanics. As strange…
The importance of fracture-healing on the deformation of fluid-filled layered systems
2014
International audience; Understanding the fracturingehealingerefracturing cycle is a fundamental part of studying the deformation dynamics and the permeability evolution of rock systems. Previous studies, however, have not examined the influence of healing i.e. fracture-closure through vein formation and the mechanical properties of the " healed " fractures (veins) on the rock deformation. We present results from a two-dimensional coupled hydro-mechanical model which simulates large time and spatial scale dynamic fracturing and healing of a porous medium under the influence of gravity, tectonic stretching and elevated fluid pressures. Our results show that healing decreases the local porosi…
Modular Small Diameter Vascular Grafts with Bioactive Functionalities.
2015
We report the fabrication of a novel type of artificial small diameter blood vessels, termed biomimetic tissue-engineered blood vessels (bTEBV), with a modular composition. They are composed of a hydrogel scaffold consisting of two negatively charged natural polymers, alginate and a modified chitosan, N,O-carboxymethyl chitosan (N,O-CMC). Into this biologically inert scaffold two biofunctionally active biopolymers are embedded, inorganic polyphosphate (polyP) and silica, as well as gelatin which exposes the cell recognition signal, Arg-Gly-Asp (RGD). These materials can be hardened by exposure to Ca(2+) through formation of Ca(2+) bridges between the polyanions, alginate, N,O-CMC, and polyP…
Porous Gelatin Hydrogels: 2. In Vitro Cell Interaction Study
2007
We report on the feasibility of applying porous gelatin hydrogels, prepared by a novel and controlled cryogenic treatment, as cell-interactive scaffolds for tissue engineering applications. Despite the large number of publications on gelatin as a biomaterial, a detailed study of screening a limited number of gelatin scaffolds for their interaction with a panel of human cells has, to the best of our knowledge, not yet been published. In the present work, we have evaluated two types of porous gelatin scaffolds that differ in their pore geometry and pore size. Type I hydrogels contained top-to-bottom transverse channels (i.e. cones) with a decreasing diameter from the top (330 microm) to the b…
Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films
2021
Anastomotic leakage is a frequent complication of intestinal surgery and a major source of surgical morbidity. The timing of anastomotic failures suggests that leaks are the result of inadequate mechanical support during the vulnerable phase of wound healing. To identify a biomaterial with physical and mechanical properties appropriate for assisted anastomotic healing, we studied the adhesive properties of the plant-derived structural heteropolysaccharide called pectin. Specifically, we examined high methoxyl citrus pectin films at water contents between 17–24% for their adhesivity to ex vivo porcine small bowel serosa. In assays of tensile adhesion strength, pectin demonstrated significant…
Maltose-conjugated chitosans induce macroscopic gelation of pectin solutions at neutral pH
2014
Injectable polymer scaffolds are particularly attractive for guided tissue growth and drug/cell delivery with minimally invasive intervention. In the present work, "all-polymeric" gelling systems based on pectins and water-soluble maltose-conjugated chitosans (CM) have been developed. Maltose-conjugated chitosan has been synthesized at three different molar ratios, as evaluated by FITR analysis and fluorimetric titration. A thorough rheological characterization of the blends and their parent solutions has been performed. Macroscopic gelation has been achieved by mixing the high esterification degree pectins with CM at higher maltose grafted to chitosan contents. Gels form in a few minutes a…