6533b834fe1ef96bd129d864

RESEARCH PRODUCT

Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films

Zi ChenCharlotta FunayaAidan PierceMaximilian AckermannWilli L. WagnerYifan ZhengHassan A. KhalilSteven J. Mentzer

subject

food.ingredientPolymers and PlasticsPectinAdhesion (medicine)Organic chemistryArticlebowelfoodQD241-441biopolymerUltimate tensile strengthmedicineCitrus PectinpectinChemistryheteropolysaccharidedigestive oral and skin physiologyBiomaterialfood and beveragesGeneral Chemistrymedicine.diseaseAdhesiveWound healingEx vivoBiomedical engineeringserosa

description

Anastomotic leakage is a frequent complication of intestinal surgery and a major source of surgical morbidity. The timing of anastomotic failures suggests that leaks are the result of inadequate mechanical support during the vulnerable phase of wound healing. To identify a biomaterial with physical and mechanical properties appropriate for assisted anastomotic healing, we studied the adhesive properties of the plant-derived structural heteropolysaccharide called pectin. Specifically, we examined high methoxyl citrus pectin films at water contents between 17–24% for their adhesivity to ex vivo porcine small bowel serosa. In assays of tensile adhesion strength, pectin demonstrated significantly greater adhesivity to the serosa than either nanocellulose fiber (NCF) films or pressure sensitive adhesives (PSA) (p &lt

yearjournalcountryeditionlanguage
2021-08-21Polymers
10.3390/polym13162811https://www.mdpi.com/2073-4360/13/16/2811