Search results for "heart"
showing 10 items of 3201 documents
Frequency of Mitoxantrone related heart involvement in patients affected by Multiple Sclerosis
2010
Acute heart failure due to giant left atrium: remote ECLS implantation for interhospital transfer and bridging to decision
2018
AbstractBackgroundRemote extracorporeal life support (ECLS) implantation and mobile ECLS are increasingly applied to enable the treatment of patients with refractory heart failure at specialized care centers. Giant left atrium (GLA) is a rare cause but may lead to acute and devastating heart failure.Case reportAcute heart failure that gave rise to a prolonged period of out-of-hospital cardiopulmonary resuscitation in a patient who underwent remote ECLS implantation was found to have resulted from a GLA of impressive dimensions. There having no reasonable option for immediate surgical therapy, the patient was successfully bridged to recovery with a view to subsequent heart transplantation.Co…
Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity
2019
Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This chang…
High Output Heart Failure in Multiple Myeloma: Pathogenetic Considerations.
2022
The high output heart failure is a clinical condition in which the systemic congestion is associated to a high output state, and it can be observed in a non-negligible percentage of hematological diseases, particularly in multiple myeloma, a condition in which the risk of adverse cardiovascular events may increase, with a worse prognosis for patients. For this reason, though an accurate literature search, we provided in this review a complete overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma. Indeed, this clinical finding is present in the 8% of multiple myeloma patients, and it may be caused by artero-venous shunts, enhanced angioge…
2020
This study focused on resolving the differences in economy between two common sit-skiing postures used by disabled athletes, suspected to be the most and least effective. Ten experienced non-disabled male cross-country skiers went through an incremental testing protocol with an ergometer simulating double poling in two sitting postures "kneeing" and "knee-high." The protocol consisted of 3 × 4 min steady-state stages (13, 22, and 34% of maximal sprint power output). Subjects' respiratory gases and heart rate were measured and blood lactate concentrations were determined. In addition, pulling forces and motion capture recordings were collected. Oxygen consumption was 15.5% (p < 0.01) higher …
MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
2008
Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…
Clinical utilization of natriuretic peptide determination in acute congestive heart failure
2010
Niewydolność serca - problem medyczny, ekonomiczny i społeczny
2019
Pierwsze wzmianki o chorobie, którą dzisiaj określamy jako niewydolność serca, pochodzą z czasów antycznych. Epidemiologia objawowej niewydolności serca jest dobrze poznana, szczególnie w Europie. Na naszym kontynencie niewydolność serca występuje u około 2% dorosłej populacji. W artykule przedstawiono: defnicję, epidemiologię i rokowanie chorych z niewydolnością serca. Opracowanie charakteryzuje aktualne metody farmakoterapii i leczenia interwencyjnego. Ważnym elementem postępowania u chorych z niewydolnością serca jest rehabilitacja medyczna i przestrzeganie zasad proflaktyki chorób sercowo-naczyniowych zalecanych przez Europejskie Towarzystwo Kardiologiczne. Artykuł porusza również temat…
Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience
2016
Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…
Respiratory Sinus Arrhythmia Mechanisms in Young Obese Subjects
2020
Autonomic nervous system (ANS) activity and imbalance between its sympathetic and parasympathetic components are important factors contributing to the initiation and progression of many cardiovascular disorders related to obesity. The results on respiratory sinus arrhythmia (RSA) magnitude changes as a parasympathetic index were not straightforward in previous studies on young obese subjects. Considering the potentially unbalanced ANS regulation with impaired parasympathetic control in obese patients, the aim of this study was to compare the relative contribution of baroreflex and non-baroreflex (central) mechanisms to the origin of RSA in obese vs. control subjects. To this end, we applied…