Search results for "hole"
showing 10 items of 2900 documents
Science and law in the time of cholera: the mystery of the biscuits in Torroja (1865)
2018
By focussing on a case of collective poisoning in 1865, four features of forensic cultures are analysed: technologies for detection, authorized voices, regulations in action and the predominant social anxieties. Local newspapers and archival documents kept in the medical academies of Barcelona and Madrid are analysed. The analysis shows the tensions between various types of proof employed in legal medicine and the ambiguities between epidemic diseases and poisoning accidents. In the first section, I review the fears caused by the cholera epidemic in 1865, which was the first explanation of the accident. The changes of popular perception are also discussed by analysing contemporary newspaper…
Gaismas pētīšana vizuālās mākslas stundās 8.klasē izmantojot camerai obscura analogu ierīci
2015
Darba autore Agnese Bināne ir izstrādājusi diplomdarbu „Gaismas pētīšana vizuālās mākslas stundās 8.klasē, izmantojot camerai obscura analogu ierīci”. Atbilstoši tēmai formulēts diplomdarba mērķis- izpētīt gaismas fenomenu un iespējas to pielietot vizuālajā mākslā, izveidot mācību uzdevumu kopu 8.klases skolēniem ar mērķi pilnveidot skolēnu prasmes un zināšanas gaismas pielietošanā vizuālajā mākslā, izmantojot camerai obscura analogu ierīci. Uzdevumu kopa veiksmīgi realizēta Rīgas Avotu pamatskolas 8.klasē. Izvirzītais mērķis sasniegts, skolēni apguvuši tēmu un pielietojuši gūtās zināšanas un prasmes darba realizēšanas procesā. Diplomdarbs sastāv no vairākām daļām. Pirmajās trīs nodaļās ir …
High-energy monitoring of NGC 4593 II. Broad-band spectral analysis: testing the two-corona model
2019
It is widely believed that the primary X-ray emission of AGN is due to the Comptonisation of optical-UV photons from a hot electron corona, while the origin of the 'soft-excess' is still uncertain and matter of debate. A second Comptonisation component, called warm corona, was therefore proposed to account for the soft-excess, and found in agreement with the optical-UV to X-ray emission of a sample of Seyfert galaxies. In this context, we exploit the broadband XMM-Newton and NuSTAR simultaneous observations of the Seyfert galaxy NGC 4593 to further test the so called "two corona model". The NGC 4593 spectra are well reproduced by the model, from the optical/UV to the hard X-rays. Moreover, …
Regulation of the activity of the Cholesteryl Ester Tranfer Protein (CETP) : electrostatics interactions with carboxylic derivatives (Non Esterified …
1997
In human plasma, the cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism by promoting the net mass transfer of cholesteryl esters from HDL towards apoB-containing lipoproteins, and the transfer of triglycerides from VLDL towards HDL and LDL. Thus CETP arises as a potentially important factor in plasma lipoproteins metabolism, a statement which raised a considerable interest in identifying the factors which may regulate CETP activity.In our in vitro studies, we demonstrated that amphipathic molecules (non esterified fatty acids and retinoic acids) constituted of one carboxylic head group and one hydrophobic carbon chain are able to increase the cholesteryl es…
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma.
2011
http://www.sciencedirect.com/; International audience; Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function, highlighting the crucial importance of maintaining cholesterol homeostasis in the retina. Our purpose was to give a review on the functioning of the retina, the role of cholesterol and cholesterol metabolism therein, with special emphasis on cholesterol-24S-hydroxylase (CYP46A1). Similar to th…
<title>Additional usage possibilities for the computerized Hess screen</title>
2003
The purpose of the study was to work out a method how to use the computerized Hess screen in proximal vergence measurements. Proximal vergence or vergence due to knowledge of nearness is one of four independent components making up the total vergence response. Proximal vergence is expressed as a ratio - proximal convergence/test distance (PC/T). The computerized Hess screen is usually used to detect and to measure an ocular misalignment in patients with paralytic strabismus in different directions of gaze. The computerized Hess screen can be used to assess PC/T ratio in different directions of gaze, providing the open-loop disparity vergence and accommodation systems and assuming that tonic…
In vivo consequences of cholesterol-24s-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina
2011
Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences of CYP46A1 inhibition by voriconazole on cholesterol homeostasis and function in the retina. Rats received daily intraperitoneal injections of voriconazole (60mg/kg), minocycline (22mg/kg), voriconazole plus minocycline, or vehicle during five consecutive days. The rats were submitted to electroretinography to monitor retinal functionality. Cholesterol and 24S-hydroxycholesterol were measured in plasma, brain and retina by gas chromatography-mass spectrometry. T…
PENENTUAN KEDALAMAN SUMUR BOR BERDASARKAN DATA GEOLISTRIK RESISTIVITAS DI BEBERAPA KAMPUNG DI KABUPATEN FAK-FAK
2018
Geoelectrical R esistivity method is a geophysical method that can be used to determine subsurface geology based on rock resistivity image. Resistivity survey has been done in some villages, in Fak Fak Regency, West Papua Province. The measurement method that used is sounding, whereas electrode configuration used is Dipole-dipole configuration with a stretch of 100 -150 m. The data obtained are then processed by Progress Res2Dinv. The results of this survey obtained show that in the resistivity sounding measurement point found any good groundwater aquifers, a s the water source of drilled well . Water layer with the thickness between 1-3 m at the surface (alluvial) is a rain water infiltrat…
Some Considerations on 3-D and 2-D Numerical Models for the Assessment of the Stability of Underground Caves
2014
The application of numerical modeling to the analysis of the stability of both natural and man-made underground caves is rapidly increasing due to the availability of powerful numerical codes, that can account for either continuum or discontinuum behavior of the rock masses. Numerical methods allow to overcome traditional methods for cave stability analysis that assume too simplified geometrical, geological and geomechanical conditions. Further, they are also able to assess the potential failure mechanisms of underground systems. On the other hand, the application of numerical methods requires availability of a detailed geo-structural survey of the cave, as well as a proper geomechanical ch…
Integration of HVSR measures and stratigraphic constraints for seismic microzonation studies: the case of Oliveri (ME)
2014
Abstract. Because of its high seismic hazard the urban area of Oliveri has been subject of first level seismic microzonation. The town develops on a large coastal plain made of mixed fluvial/marine sediments, overlapping a complexly deformed substrate. In order to identify points on the area probably suffering relevant site effects and define a preliminary Vs subsurface model for the first level of microzonation, we performed 23 HVSR measurements. A clustering technique of continuous signals has been used to optimize the calculation of the HVSR curves. 42 reliable peaks of the H/V spectra in the frequency range 0.6–10 Hz have been identified. A second clustering technique has been applied t…