Search results for "hole"
showing 10 items of 2900 documents
Inhibition of xanthine oxidase to prevent statin-induced myalgia and rhabdomiolysis
2015
Although statins remain the cornerstone of lipid-lowering therapy for reducing the burden of atherosclerotic vascular disease, their administration has been associated with muscle-related adverse effects, including myalgia and rhabdomyolysis. Such adverse events are probably due to reduced antioxidant defenses associated with fewer intermediate metabolites in the cholesterol synthesis pathway. We hypothesize that the concomitant inhibition of xanthine oxidase via coadministration of allopurinol with statins could diminish reactive oxygen species (ROS)-related muscle damage, which would have in turn have positive effects on both the incidence of muscle-related adverse events and cardiovascul…
Open-label ODYSSEY APPRISE study: Interim data from the first 843 participants
2018
Background PCSK9 inhibitors (PCSK9i) have been recommended by the ESC/EAS Task Force in very high risk subjects with ASCVD and those with heterozygous familial hypercholesterolemia (HeFH) with persistent high LDL-C levels despite maximally tolerated LLT. Purpose ODYSSEY APPRISE (NCT02476006) is the first study to assess efficacy and safety at Week (W) 12 of the PCSK9i alirocumab (ALI) in a real-life setting prior to commercial availability. Methods APPRISE was an open-label, single-arm study, conducted in 16 European countries and Canada. Subjects with inadequately controlled lipid levels despite maximally tolerated LLT were included. Based on physician's judgment, participants received eit…
Management of Statin Intolerance in 2018: Still More Questions Than Answers.
2018
Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…
Changes of several metabolic parameters of soya inoculated with phytopathogens at application nanochelates
2022
n greenhouse experiments changes in several metabolic parameters soybeans plants after inoculation by P. savastanoi pv. glycinea 9190, X. axonopodis pv. glycines 9192, BCMV, A. laidlawii on background pre-treatment by nanochelates (NHs) of V, Ge, Cu, Mo have been shown. The phenolic compounds content increased in leaves at inoculation by phytopathogens on background pre-treatment by NHs and without it. The content of H2O2 in leaves increased in variants: BCMV (+VNHs, GeNHs, CuNHs), 9192 (+VNHs, CuNHs), 9190 (+GeNHs, CuNHs), A. laidlawii+MoNHs. But it decreased in the variants: BCMV + MoNHs, A. laidlawii + VNHs, 9190 + VNHs, 9192 (+ GeNHs, CuNHs) compared to controls. The peroxidase activity…
CCK-8S systemic administration blocks the 7-nitroindazole-induced effects on the EEG of striatum and globus pallidus: a FFT analysis in the rat
2004
Background: Nitric oxide (NO) and cholecystokinin (CCK) are involved in the modulation of several neurotransmitter systems in the basal ganglia, and a functional interaction between their modulatory effects could be hypothesised. Materials and Methods: We studied the effects exerted by the administration of 7-nitroindazole (7-NI) (50 mg kg-1 i.p.), a selective inhibitor of neuronal NO synthase, on the depth EEG activity of the striatum and of the globus pallidus in both not pre-treated and sulphated CCK octapeptide (CCK- 8S)-treated (100 nM kg-1 i.p.) rats. Striatal and pallidal depth EEG power spectra were examined by means of a Fast Fourier Transform analysis. Results: Striatal depth reco…
Population Properties of Compact Objects from the Second LIGO-Virgo Gravitational-Wave Transient Catalog
2021
Abbott, R., et al. (LIGO and Virgo Collaboration)
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a
2022
Abbott, R., et al. (LIGO and VIRGO Collaboration)
The advanced Virgo longitudinal control system for the O2 observing run
2020
Following a successful period of data-taking between 2006 and 2011, the Virgo gravitational-wave detector was taken offline for a major upgrade. The changes made to the instrument significantly increased the complexity of the control systems and meant that an extended period of commissioning was required to reach a sensitivity appropriate for science data-taking. This commissioning period was completed in July of 2017 and the second-generation Advanced Virgo detector went on to join the Advanced LIGO detectors in the O2 science run in August of the same year. The upgraded detector was approximately twice as sensitive to binary neutron star mergers as the first-generation instrument. During …
GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral
2017
On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…
Impact of pharmacological and environmental manipulations on neuronal structural plasticity and dynamics
2017
El sistema nervioso de vertebrados es uno de los más estudiados, aunque peor comprendidos, del organismo de mamíferos. Desde que Ramón y Cajal postuló su teoría celular de este sistema (Ramón y Cajal 1909), la neurona se ha postulado como su unidad funcional. Sin embargo, durante las últimas décadas se ha revolucionado la visión que se tenía de éste. Una de las percepciones más asentadas era que, tras el desarrollo embrionario, el sistema nervioso se mantenía inmutable. Sin embargo, ahora sabemos que diferentes formas de plasticidad gobiernan su adaptación, que son necesarias para importantes procesos del día a día, tales como el aprendizaje y la memoria (Smythies 2002; Berlucchi and Buchte…