Search results for "hole"

Genome degeneration and adaptation in a nascent stage of symbiosis

2014

Symbiotic associations between animals and microbes are ubiquitous in nature, with an estimated 15% of all insect species harboring intracellular bacterial symbionts. Most bacterial symbionts share many genomic features including small genomes, nucleotide composition bias, high coding density, and a paucity of mobile DNA, consistent with long-term host association. In this study, we focus on the early stages of genome degeneration in a recently derived insect-bacterial mutualistic intracellular association. We present the complete genome sequence and annotation of Sitophilus oryzae primary endosymbiont (SOPE). We also present the finished genome sequence and annotation of strain HS, a close…

Steroidal derivatives of nitrogen containing compounds as potential gelators

2013

Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors

2011

Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…

Effect of cholesterol-lowering treatment with a 585 on plasma membrane function and liver electron microscope appearence in rats.

1990

Data from: Genomics of speciation and introgression in Princess cichlid fishes from Lake Tanganyika

2016

How variation in the genome translates into biological diversity and new species originate has endured as the mystery of mysteries in evolutionary biology. African cichlid fishes are prime model systems to address speciation-related questions for their remarkable taxonomic and phenotypic diversity, and the possible role of gene flow in this process. Here, we capitalize on genome sequencing and phylogenomic analyses to address the relative impacts of incomplete lineage sorting, introgression and hybrid speciation in the Neolamprologus savoryi-complex (the ‘Princess cichlids’) from Lake Tanganyika. We present a time-calibrated species tree based on whole-genome sequences and provide strong ev…

Validation of the use of a circulating biomarker of retinal omega-3 polyunsaturated fatty acids in supplementation conditions: the BLISAR project

2019

Cholesterol homeostasis and retinal stress in anterior ischemic optic neuropathy

2016

Purpose: Anterior ischemic optic neuropathy (AION) is characterized by acute stress of retinal ganglion cells (RGC). Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in RGC where it may exert neuroprotective properties by preventing from cholesterol accumulation via catalyzing the formation of 24S-hydroxycholesterol. Previous findings hypothesize the housekeeping importance of CYP46A1 in the maintenance of cholesterol in the retina. In order to better understand the role of CYP46A1 in the retina, we aimed to define whether CYP46A1 expression and 24S-hydroxycholesterol levels were modified during RGC stress in AION.Methods: Ninety nine male Sprague Dawley rats were randomized …

Use of Hybrid Methods (Hole-Drilling and Ring-Core) for the Analysis of the RS on Welded Joints

2022

The hybrid methods (HMs) for the residual stress (RS) analysis, such as the well-known hole-drilling method (HDM) and the ring-core method (RCM), have been widely developed since 80’. They are mechanical methods based on the partial relaxation of the RSs that occur when a proper geometry variation of the analysed component is introduced by drilling a hole (HDM) or a proper annular groove (RCM). The RS computation is performed by measuring the strains relaxed on surface and then by combine properly such measured strains with the influence coefficients previously computed accurately by using a numerical codes that consider the geometry of the particular component to be examined. In such a man…

Environmental hazard and water quality: the River Platani basin

2007

The River Platani, situated in the western side of Sicily, is one of the greatest rivers of the island. It runs for about 103 Km and the basin extends to about 1,784.9 Km. It rises near Santo Stefano Quisquina (Ag); the river flows to Capo Bianco (Ag) ends in the Mediterranean Sea. The morphology of the basin is predominantly characterized by rises of modest entities with slopes sweet or calanques. In the containing gypsum and carbonatic stony heaps are diffused the karst phenomena. In the Platani basin some mines are located of rock salt and potassium salts; today the mines are closed after a long activity and they interact with the geomorphology of the territory and on the water quality o…

Efficacy of Long-Term Treatment of Autosomal Recessive Hypercholesterolemia With Lomitapide: A Subanalysis of the Pan-European Lomitapide Study

2022

Backgroundand aim: Autosomal recessive hypercholesterolemia (ARH) is a rare autosomal recessive disorder of low-density lipoprotein (LDL) metabolism caused by pathogenic variants in the LDLRAP1 gene. Like homozygous familial hypercholesterolemia, ARH is resistant to conventional LDL-lowering medications and causes a high risk of atherosclerotic cardiovascular diseases (ASCVDs) and aortic valve stenosis. Lomitapide is emerging as an efficacious therapy in classical HoFH, but few data are available for ARH.Results: This is a subanalysis carried out on nine ARH patients included in the Pan-European Lomitapide Study. The age at starting lomitapide was 46 (interquartile range (IQR), 39.0–65.5) y…