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Transcription factors controlling development and function of innate lymphoid cells.
2014
Abstract Innate lymphoid cells (ILCs) are a heterogeneous group of lymphocytes, which play an important role in tissue homeostasis at epithelial surfaces. They are scarce in spleen and lymph nodes, but substantial numbers can be found in the intestinal mucosa even at steady state. There, they represent the first line of defence against invading pathogens and contribute to lymphorganogenesis, tissue repair and, when inappropriately activated, immune pathology. Lineage-specific development, function and maintenance of these cells depend on a restricted set of transcription factors that partially emerged as a result of diversification and selection during vertebrate evolution. The differential…
From different neurophysiological methods to conflicting pathophysiological views in migraine: a critical review of literature.
2014
Abnormal increased cortical responsivity to various types of stimuli plays a major role in migraine pathogenesis. Neurophysiological studies, however, have provided ambiguous findings of either hypo or hyper cortical excitability. This is why the term "dysexcitability" has been recently proposed to indicate a more general dysregulation of cortical excitability. The aims of this review are: (1) to provide existing knowledge and research advances in migraine pathophysiology; (2) to propose a unitary interpretation of apparently conflicting neurophysiological findings. Data of studies conducted in migraine through various evoked potentials techniques and non-invasive brain stimulation methods …
Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effect…
2005
We have compared four human subsets of Vgamma9Vdelta2 T cells, naive (T(naive), CD45RA(+)CD27(+)), central memory (T(CM), CD45RA(-)CD27(+)), effector memory (T(EM), CD45RA(-)CD27(-)) and terminally differentiated (T(EMRA), CD45RA(+)CD27(-)), for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Cytokine responsiveness and IL-15R expression were low in T(naive) cells and progressively increased from T(CM) to T(EM) and T(EMRA) cells. In contrast, the capacity to expand in response to antigen or cytokine stimulation showed a reciprocal pattern and was associated with resistance to cell death and Bcl-2 expression. Whereas antigen-stimulated cells a…
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Sulle origini della ‘telicità’: κίνησις ed ἐνέργεια in Aristotele
2014
Nell’ambito della classificazione aspettuale dei verbi un ruolo particolare riveste la distinzione del tratto telico-atelico, alla base della tradizionale suddivisione tra le classi vendleriane rispettivamente di accomplishment e achievement da una parte e states e activities dall’altra. Nonostante la rilevanza di tale tratto nella riflessione linguistica contemporanea, a tutt’oggi gli studiosi non condividono una definizione univoca della telicità, soprattutto perché dietro ad ogni definizione si nasconde una diversa prospettiva teorica. Scopo del presente lavoro è un’analisi dell’origine del termine nella teoria linguistica, che è solita ricondurre la distinzione del tratto telico-atelico…
Bakteryjne strategie wykorzystania jonów metali – kulisy chemii koordynacyjnej
2022
n the Biological Inorganic Chemistry Group we are inspired to better understand metal ions acquisition and homeostasis in pathogenic bacteria, and in this review we present three different approaches to the role of these processes. The growing importance of a full understanding of the iron transport system in pathogens prompted us to study synthetic analogs of siderophores, used as structural probes in the process of iron uptake by microorganisms. The ferrichrome biomimetic analogs allowed efficient Fe(III) chelation under biological conditions and were recognized better by P. putida. than E. coli, suggesting differences in uptake mechanisms. Addition of a fluorescent probe to the compound …
Trade-offs among intensive forestry, ecosystem services and biodiversity in boreal forests
2018
Finnish forests are used extensively for timber production but are also providers of other ecosystem services and harbor unique biodiversity. The ecosystem services approach has so far been used marginally in the context of Finnish forestry; however, due to the multiple values associated with Finnish forests and the impacts forestry operations have on forest ecosystems, it is clearly applicable in this context. In this thesis, I studied the occurrence and severity of trade-offs among ecosystem services and biodiversity conservation in Finnish forests. I used forest inventory data, forest growth simulations, and multi-objective optimization to reveal how the severity of the trade-offs varies…
Phenotypic and genetic characterization of emerging trematodiasis: Fascioliasis and Schistosomiasis
2021
La Fascioliasis y la Esquistosomiasis son dos importantes trematodiasis (re)emergentes con gran impacto en la salud humana. Dada la necesidad de caracterizar las poblaciones de Trematodos involucradas, los objetivos de la presente investigación son: en primer lugar, analizar el impacto de la reinfección experimental por Fasciola hepatica en los fenotipos inmunológicos, clínicos y biológicos por medio de un diseño experimental que reproduce las condiciones habituales de reinfección/cronicidad en las zonas endémicas de la Fascioliasis humana; en segundo lugar, la caracterización fenotípica morfológica de huevos de Schistosoma haematobium de migrantes subsaharianos con Esquistosomiasis urogeni…
Kulturell kompetanse i hjemmetjenesten
2019
Masteroppgave klinisk helsevitenskap ME520 - Universitetet i Agder 2019 Introduction:The increase in the number of non-ethnic Norwegian patients in home care has led to the need for cultural competence in the home nurse. Lack of cultural competence in the home nurse can and has created challenges such as discrimination, poor health service and communication with these patients. The purpose of this study is toexamine the cultural competenceof home nurses in district in South Norway.The researchquestion: What cultural competence do home nurses have when tending to patients of minority ethnicities?Methods:Descriptive cross-section study was carried out on the present study. For data collection…
Miłosierdzie w praktyce Domu Matki i Dziecka w Opolu
2016
Dom Matki i Dziecka w Opolu jest jedną z instytucji Diecezjalnej Fundacji Ochrony Życia. Powstał on w 1994 r. Od początku swego istnienia udzielił schronienia ponad 1000 kobiet i ich dzieciom. Wszystkie te osoby mogą liczyć na szeroką pomoc materialną, socjalną, psychologiczną, pedagogiczną, prawną i duchową. Czas pobytu w Domu ma stać się okazją do konstruktywnego rozwiązania ich problemów życiowych. Ważnymi elementami funkcjonowania tej placówki jest etapowość udzielanego wsparcia oraz dążenie do zwiększenia samodzielności każdej matki, tak by stawała się ona w pełni wydolną wychowawczynią dla swego dziecka. Artykuł przybliża historie powstania tej placówki, złożenia jej funkcjonowania or…