Search results for "host"

Enriched rearing environment and wild genetic background can enhance survival and disease resistance of salmonid fishes during parasite epidemics

2015

Summary 1. The importance and volume of aquaculture is increasing world-wide. Rearing practices play a key role in determining growth rate, survival and disease resistance in aquaculture fishes. Recent evidence suggests that in comparison with a standard stimulus-poor rearing environment, an enriched or variable rearing environment has significant positive effects on several traits underlying growth and well-being of fish. However, the effect of enriched rearing on one of the most important threats for aquaculture development, occurrence of parasitic infections, remains unknown. 2. We used surveillance data of experimental salmonid populations of wild and hatchery origin under semi-natural …

2019

Global changes promote the spread of infectious diseases worldwide. In this context, tropical urogenital schistosomiasis is now permanently established in Corsica since its first emergence in 2013. The local persistence of the tropical pathogens (schistosomes) responsible for urogenital schistosomiasis at such latitudes might be explained by (i) the presence of its intermediate host, the snail Bulinus truncatus, (ii) the recurrent local reseeding of schistosomes by their vertebrate hosts (either human or animal) every summer, and/or (iii) the maintenance and survival of schistosomes within their snail hosts over winter. In this study we conducted an ecological experiment to assess the abili…

Outside-host predation as a biological control against an environmental opportunist disease

2017

Abstract Environmentally growing opportunist pathogens are a common threat to human health and food production. Due to environmental growth of the pathogen, these diseases are difficult to control with disinfectants and antibiotics. Thus, there is a need for sustainable and effective control methods against environmentally growing opportunist diseases. Predation is often a major limiting factor in the outside host environment. Here we propose that it could be used in the biological control of these diseases. We introduce a novel epidemiological model for environmentally growing opportunists combining pathogen growth within-host (SI model) and outside-host into classical predator-prey model.…

The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen

2019

AbstractViruses are key actors of ecosystems and have major impacts on global biogeochemical cycles. Prophages deserve particular attention as they are ubiquitous in bacterial genomes and can enter a lytic cycle when triggered by environmental conditions. We explored how temperature affects the interactions between prophages and other biological levels by using an opportunistic pathogen, the bacterium Serratia marcescens, that harbours several prophages and that had undergone an evolution experiment under several temperature regimes. We found that the release of one of the prophages was temperature-sensitive and malleable to evolutionary changes. We further discovered that the virulence of …

Coronavirus disease 2019 infection and the cardiovascular system

2020

Splenic Littoral Cell Hemangioendothelioma in a Patient With Crohn's Disease Previously Treated With Immunomodulators and Anti-TNF Agents: A Rare Tum…

2011

Th e risk of malignancy in Crohn ’ s disease (CD) has been well described. Moreover, immunomodulators, uch as azathioprine (AZA) and 6-mercaptopurine (6-MP), and biological agents, such as infl iximab and adalimumab, may promote carcinogenesis ( 1 – 3 ). Splenic littoral cell tumors are recently described tumors of vascular origin composed of endothelial cells, with typical microscopic and immunohistochemical features of splenic sinus lining cells ( 4 ). Clinical findings are not specific, and outcome is unpredictable but usually benign, although a few cases with a malignant behavior have been reported ( 5,6 ). We report a 58-year-old Caucasian man with a long history of ileocolonic CD.

Recomendaciones en el manejo de la pandemia por coronavirus SARS-CoV-2 (Covid-19) en pacientes con trasplante renal

2020

The SARS-CoV-2 (Covid-19) coronavirus pandemic is evolving very quickly and means a special risk for both immunosuppressed and comorbid patients. Knowledge about this growing infection is also increasing although many uncertainties remain, especially in the kidney transplant population. This manuscript presents a proposal for action with general and specific recommendations to protect and prevent infection in this vulnerable population such as kidney transplant recipients. Resumen: La pandemia por coronavirus SARS-CoV-2 (Covid-19) está evolucionando de manera muy rápida y representa un riesgo especial en pacientes inmunodeprimidos y con comorbilidades añadidas. El conocimiento sobre esta in…

Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell

2019

Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae.…

Seasonal and depth related variation of parasite communities of Notacanthus bonaparte Risso, 1840 (Notacanthiformes: Notacanthidae) over the northwes…

2019

Abstract In the last decades fishing activities have spread from coastal to deeper waters with serious effects on the deep-sea ecosystems and its fauna, which are considered to be highly susceptible to these impacts. The implementation of protection measures is necessary, but the knowledge on this biome is scant, and often limited to species of commercial value. To the best of our knowledge, this study is the first survey to describe and analyse parasite infracommunities of the deep-sea fish Notacanthus bonaparte sampled from three bathymetric strata between the upper and lower slope in the western Mediterranean Sea (Balearic Sea, Spain). The aim of this work was to assess the effect of hos…

Biological Basis of the HLA-B8,DR3-Associated Progression of Acquired Immune Deficiency Syndrome

1998

The factors influencing the evolution of human immunodeficiency virus (HIV) infection are not fully known, but the host genotype undoubtedly plays a role in determining the outcome of the disease by affecting the immune response to HIV. The role of the host human leukocyte antigen (HLA) genotype in the regulation of susceptibility to HIV infection and expression has been studied extensively in different major risk groups. Certain HLA alleles and haplotypes, being associated with aberrant immune responses independently from HIV infection, have been reported to facilitate the rapid progression of disorders related to HIV infection. Particularly, the association of rapid acquired immunodeficie…